454 research outputs found
Social capital, government expenditures, and growth
We present a tractable stochastic endogenous growth model that explains how social capital influences economic development. In our model, social capital increases citizens' awareness of government activity. Hence, it alleviates the electoral incentives to under- invest in education, whose returns are delayed and less visible to voters. In equilibrium, higher social capital raises the average output growth rate and reduces its volatility by increasing public investment in education while making its returns higher and less variable. Our theory also predicts that a more unequal distribution of social capital reduces public education expenditures. We provide suggestive cross-country evidence consistent with these predictions.Social Capital, Education Expenditures, Economic Growth, Elections, Government Expenditures, Imperfect Information
Clusters of Entrepreneurship
Employment growth is strongly predicted by smaller average establishment size, both across cities and across industries within cities, but there is little consensus on why this relationship exists. Traditional economic explanations emphasize factors that reduce entry costs or raise entrepreneurial returns, thereby increasing net returns and attracting entrepreneurs. A second class of theories hypothesizes that some places are endowed with a greater supply of entrepreneurship. Evidence on sales per worker does not support the higher returns for entrepreneurship rationale. Our evidence suggests that entrepreneurship is higher when fixed costs are lower and when there are more entrepreneurial people.Entrepreneurship, Industrial Organization, Chinitz, Agglomeration, Clusters, Cities.
Skeletal Myogenic Progenitors Originating from Embryonic Dorsal Aorta Coexpress Endothelial and Myogenic Markers and Contribute to Postnatal Muscle Growth and Regeneration
Skeletal muscle in vertebrates is derived from somites, epithelial structures of the paraxial mesoderm, yet many unrelated reports describe the occasional appearance of myogenic cells from tissues of nonsomite origin, suggesting either transdifferentiation or the persistence of a multipotent progenitor. Here, we show that clonable skeletal myogenic cells are present in the embryonic dorsal aorta of mouse embryos. This finding is based on a detailed clonal analysis of different tissue anlagen at various developmental stages. In vitro, these myogenic cells show the same morphology as satellite cells derived from adult skeletal muscle, and express a number of myogenic and endothelial markers. Surprisingly, the latter are also expressed by adult satellite cells. Furthermore, it is possible to clone myogenic cells from limbs of mutant c-Met-/- embryos, which lack appendicular muscles, but have a normal vascular system. Upon transplantation, aorta-derived myogenic cells participate in postnatal muscle growth and regeneration, and fuse with resident satellite cells.
The potential of the vascular system to generate skeletal muscle cells may explain observations of nonsomite skeletal myogenesis and raises the possibility that a subset of satellite cells may derive from the vascular system
Thermal Physics and Glaucoma II: Preliminary Evidences for a Thermophysical Design of a Possible Visible-Light-Photons Therapy
Recently, a non-equilibrium thermodynamic approach has been developed in order to model the fundamental role of the membrane electric potential in the cell behaviour. A related new
viewpoint is introduced, with a design of a photobiomodulation treatment in order to restore part of the visual field. Here, a first step in experimental evidence of the validity of the thermodynamic approach is developed. This result represents the starting point for future experimental improvements for light stimulation in order to improve the quality of life of the patients. The future possible therapy will be in addition to the pharmacological treatments
Extremely low frequency electromagnetic fields affect proliferation and mitochondrial activity of human cancer cell lines
Prima [-secunda] pars phylosophie naturalis
Cada parte con port. propia y colofónDatos de publicación tomados del colofón de la primera parte. --Sign.: aaa-kkk6, a-q6, r8Ambas port. con esc. episcopal. -- Ambas port. enmarcadas en orla grab
The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection
Alternative treatment strategies are necessary to reduce the severity of glaucoma, a group
of eye conditions that progressively damage the optic nerve and impair vision. The aim of this review
is to gain insight into potentially exploitable molecular mechanisms to slow down the death of retinal
ganglion cells (RGCs), a fundamental element in the pathophysiology of all forms of glaucoma, and
to stimulate adult optic nerve repair. For this purpose, we focus our analysis on both visible and
far-red to near-infrared light photobiomodulation (PBM) as phototherapeutic agents, which were
recently proposed in RGCs, and on the nerve lamina region neural progenitor cell (ONLR-NPC)
niche. Both are suggested as potential strategies in glaucoma neuroprotection. We discuss the impact
of beneficial molecular effects of PBM on both mitochondrial derangement and the alteration of
ion fluxes that are considered important causes of RGC damage, as well as on the stimulation of
progenitor cells. We suggest these are the most promising approaches to prevent excessive neuronal
cell loss. We describe the experimental evidence supporting the validity of PBM therapy which,
despite being a safe, non-invasive, inexpensive, and easy to administer procedure, has not yet been
fully explored in the clinical practice of glaucoma treatment
Failure to downregulate the BAF53a subunit of the SWI/SNF chromatin remodeling complex contributes to the differentiation block in rhabdomyosarcoma
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Specific Uncoupling of GRB2 from the Met Receptor DIFFERENTIAL EFFECTS ON TRANSFORMATION AND MOTILITY
The biological effects of hepatocyte growth factor/scatter factor are mediated by autophosphorylation of its receptor, the Met tyrosine kinase, on two carboxyl-terminal tyrosines. These phosphotyrosines (Y1349VHVNATY1356VNV) are multifunctional docking sites for several effectors. Grb2, the adaptor for the Ras guanyl-nucleotide exchanger SOS, binds to Tyr1356 in the YVNV motif. By site-directed mutagenesis we either abrogated or duplicated the Grb2 consensus, without interfering with the other effectors. Loss of the link with Grb2 severely impaired transformation. The same mutation, however, had no effect on the "scattering" response, indicating that the level of signal which can be reached by Grb2-independent routes is permissive for motility. Duplication of the Grb2 binding site enhanced transformation and left motility unchanged. Thus, two Met-mediated biological responses, motility and growth, can be dissociated on the basis of their differential requirement for a direct link with Ras
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