4 research outputs found
Sintesi ed attività  biologica di diossolo[4,5-f]indoli-3-beta-diketoacidi e studi di docking nel sito attivo dell'enzima HIV-1 integrasi
In precedenti comunicazioni stata riportata la sintesi di indoli 2-(3-)-β-diketoacidi 1a-f e
2a,c,e. In questo studio è riportata la sintesi, l'attività  biologica e gli studi di modellistica molecolare
condotti sui derivati 2b,d a completamento delle precedenti ricerche
Synthesis and Biological Evaluation of Triazolo[4,5-<I>g</I>]quinolines, Imidazo[4,5-<I>g</I>]quinolines and Pyrido[2,3-<I>g</I>]quinoxaline. Part II
Synthesis of triazolo[4,5-g]quinolines, imidazo[4,5-g]quinolines and pyrido[2,3-g]quinoxaline has been described. Antimycobacterial, antibacterial and antimycotic activity were also reported. Compounds (14) and (IIb) exhibited an interesting antimycobacterial activity (against M. tuberculosis and M. smegmatis)
New 6-nitroquinolones: synthesis and antimicrobial activities
Pursuing our searches on quinolonecarboxylic acids we used a simple three-step one pot procedure to synthesize novel 1,7-disubstituted-6-nitroquinolones. The new derivatives were tested against Mycobacterium tuberculosis and Mycobacterium avium complex (MAC) as well as against both gram-positive and gram-negative bacteria. In vitro assays showed some derivatives were endowed with good inhibiting activities against tested mycobacteria. Some derivatives were also found more potent than ciprofloxacin and ofloxacin (used as reference drugs) against gram-positive bacteria