39 research outputs found
Flavour anti- algorithm applied to production at the LHC
We apply the recently proposed flavoured anti- jet algorithm to
production at the Large Hadron Collider at TeV. We
present results for the total cross section and differential distributions at
the next-to-next-to-leading order (NNLO) in QCD. We discuss the effects of the
remaining parametric freedom in the flavoured anti- prescription,
and compare it against the standard flavour- algorithm. We
compare the total cross section results against the CMS data, finding good
agreement. The NNLO QCD corrections are significant, and their inclusion
substantially improves the agreement with the data.Comment: 12 Figures, 19 page
Isolated photon production in association with a jet pair through next-to-next-to-leading order in QCD
In this work, we provide a comprehensive set of differential cross-section
distributions for photon + di-jet production in proton-proton collisions with
next-to-next-to-leading order precision in massless QCD. The event selection
corresponds to recent measurements by the ATLAS collaboration. We observe an
improved description of data in comparison to lower-order calculations in the
case of observables that are expected to be well described by perturbation
theory. The results also show better agreement with data than
parton-shower-matched and multi-jet-merged predictions generated for the ATLAS
analysis using the \textsc{Sherpa} Monte Carlo. A particular highlight of our
study is the use of exact five-point two-loop virtual amplitudes. This is the
first calculation of a complete two-to-three hadron-collider process at
next-to-next-to-leading order in QCD that does not rely on the leading-colour
approximation at two loops. We demonstrate, nevertheless, that the
sub-leading-colour effects present in the infrared- and ultraviolet-finite
double-virtual contributions are negligible in view of the remaining scale
uncertainties.Comment: 32 pages, 9 figures, 3 tables. Amplitudes in electronic format
available under https://doi.org/10.5281/zenodo.782496
Multilevel factors are associated with immunosuppressant nonadherence in heart transplant recipients: The international BRIGHT study
Factors at the level of family/healthcare worker, organization, and system are neglected in medication nonadherence research in heart transplantation (HTx). The 4-continent, 11-country cross-sectional Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation (BRIGHT) study used multistaged sampling to examine 36 HTx centers, including 36 HTx directors, 100 clinicians, and 1397 patients. Nonadherence to immunosuppressants\u2014defined as any deviation in taking or timing adherence and/or dose reduction\u2014was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale \ua9 (BAASIS \ua9 ) interview. Guided by the Integrative Model of Behavioral Prediction and Bronfenbrenner's ecological model, we analyzed factors at these multiple levels using sequential logistic regression analysis (6 blocks). The nonadherence prevalence was 34.1%. Six multilevel factors were associated independently (either positively or negatively) with nonadherence: patient level: barriers to taking immunosuppressants (odds ratio [OR]: 11.48); smoking (OR: 2.19); family/healthcare provider level: frequency of having someone to help patients read health-related materials (OR: 0.85); organization level: clinicians reporting nonadherent patients were targeted with adherence interventions (OR: 0.66); pickup of medications at physician's office (OR: 2.31); and policy level: monthly out-of-pocket costs for medication (OR: 1.16). Factors associated with nonadherence are evident at multiple levels. Improving medication nonadherence requires addressing not only the patient, but also family/healthcare provider, organization, and policy levels
Validation of the patient assessment of chronic illness care (PACIC) short form scale in heart transplant recipients: The international cross-sectional bright study
Background: Transplant recipients are chronically ill patients, who require lifelong follow-up to manage co-morbidities and prevent graft loss. This necessitates a system of care that is congruent with the Chronic Care Model. The eleven-item self-report Patient Assessment of Chronic Illness Care (PACIC) scale assesses whether chronic care is congruent with the Chronic Care Model, yet its validity for heart transplant patients has not been tested. Methods: We tested the validity of the English version of the PACIC, and compared the similarity of the internal structure of the PACIC across English-speaking countries (USA, Canada, Australia and United Kingdom) and across six languages (French, German, Dutch, Spanish, Italian and Portuguese). This was done using data from the cross-sectional international BRIGHT study that included 1378 heart transplant patients from eleven countries across 4 continents. To test the validity of the instrument, confirmatory factor analyses to check the expected unidimensional internal structure, and relations to other variables, were performed. Results: Main analyses confirmed the validity of the English PACIC version for heart transplant patients. Exploratory analyses across English-speaking countries and languages also confirmed the single factorial dimension, except in Italian and Spanish. Conclusion: This scale could help healthcare providers monitor level of chronic illness management and improve transplantation care. Trial registration: Clinicaltrials.gov ID: NCT01608477, first patient enrolled in March 2012, registered retrospectively: May 30, 2012
Report of the Topical Group on Top quark physics and heavy flavor production for Snowmass 2021
This report summarizes the work of the Energy Frontier Topical Group on EW
Physics: Heavy flavor and top quark physics (EF03) of the 2021 Community Summer
Study (Snowmass). It aims to highlight the physics potential of top-quark
studies and heavy-flavor production processes (bottom and charm) at the HL-LHC
and possible future hadron and lepton colliders and running scenarios
Blood coagulation and beyond:Position paper from the Fourth Maastricht Consensus Conference on Thrombosis
The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The coagulome as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.</p
Blood coagulation and beyond: position paper from the fourth Maastricht consensus conference on thrombosis
The Fourth Maastricht Consensus Conference on Thrombosis included the following themes. Theme 1: The "coagulome" as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow, and kidney. Four investigators shared their views on these organ- specific topics. Theme 2: Novel mechanisms of thrombosis. Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infection-associated coagulopathies perturb the hemostatic balance resulting in thrombosis and/ or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies. This theme included state-of- the- art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: the value and limitations of ex vivo models. Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularized organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation-associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management. Plenary presentations addressed controversial areas, i. e., thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies, and clinically tested factor XI(a) inhibitors, both possibly with reduced bleeding risk. Finally, COVID- 19-associated coagulopathy is revisited.Nephrolog
Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis
The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The coagulome as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited
Mental Health Initiatives for (Psychiatric) Trainees: Current state
info:eu-repo/semantics/publishe
NNLO QCD corrections to production at the LHC
We compute theoretical predictions for the production of a W-boson in
association with a bottom-quark pair at hadron colliders at
next-to-next-to-leading order (NNLO) in QCD, including the leptonic decay of
the W-boson, while treating the bottom quark as massless. This calculation
constitutes the very first process with a massive external particle
to be studied at such a perturbative order. We derive an analytic expression
for the required two-loop five-particle amplitudes in the leading colour
approximation employing finite-field methods. Numerical results for the cross
section and differential distributions are presented for the Large Hadron
Collider at TeV. We observe an improvement of the perturbative
convergence for the inclusive case and for the prediction with a jet veto upon
the inclusion of the NNLO QCD corrections.Comment: 6 pages, 3 figure, analytical expressions for the two-loop amplitudes
are provided in the ancillary files, numerical results for the differential
cross section are provided in the ancillary files. v2: fixed minor typos in
the tex