150 research outputs found
Physical restraint in the provision of medical care in somatic hospital: ethics and law
The ethics and legality of the use of physical restraint (PR) in the case of patients with acute mental disorders in general practice are discusse
The association of rs12444979 and rs2241423 genotype combination with the risk of uterine hyperplastic processes
A lot of women of fertile and predecidual age have hyperplastic processes of endometrium having a risk of malignization in 10-50% of cases. The present study investigated an association between rs12444979 and rs2241423 polymorphisms and risk of uterine hyperplastic processes in Russian wome
Stigmatisation and self-stigmatisation of patients with mental disorders committed suicide attempts
This study aims to determine clinical characteristics of stigmatisation and self-stigmatisation of patients who committed suicide attempts on the basis of "mental illness" and "suicide
Association of genetic polymorphisms rs4374421, rs7759938 and rs466639 with uterine hyperplastic processes
Uterine hyperplastic processes such as of endometrium, uterine leiomyoma, genital endometriosis are mostly common pathological conditions among gynaecological diseases. The disorders have shared pathogenetic mechanisms and may be diagnosed in combination
The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population
The present study was designed to investigate whether common single-nucleotide polymorphisms (SNP) of CYP2C gene subfamily such as CYP2C8 (rs7909236 and rs1934953), CYP2C9 (rs9332242), and CYP2C19 (rs4244285) are associated with susceptibility to EH in Russian populatio
Genes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis
In this study, we analyzed association of genes of vascular homeostasis with hypertension and renal survival of CGN patients. The study sample included 238 patients with CGN and 304 healthy subjects of population control. Ten polymorphisms of ten genes of vascular homeostasis were genotyped through polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) analysis and TaqMan assays. Association of the genotypes with renal survival was analyzed by the Kaplan-Meier estimato
The relationship between the - 344С˃T polymorphism of gene encoding aldosterone synthase and the prothrombin time in patients with intracerebral hemorrhage
Gene encoding aldosterone synthase gene (CYP11B2), has been suggested to contribute to stroke. The present study was designed to investigate whether common functional polymorphism −344C>T (rs179998) of the CYP11B2 gene is associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH) in a Russian populationyesBelgorod State National Research Universit
Pharmacogenetic study of lipid-lowering therapy with rosuvastatin in coronary artery disease patients
Polymorphic genes involved in the regulation of lipid metabolism may be responsible for interindividual differences in efficiency of hypolipidaemic therapy. In the present prospective and randomised study, we investigated the efficacy of rosuvastatin (10 mg/day) in lipid-lowering therapy in 62 patients with coronary artery disease (CAD) possessing different genotypes of lipoprotein lipase (LPL) gen
Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population
Epoxyeicosatrienoic acids (EETs) are important vasoactive products of arachidonic acid metabolism with a wide range of biological actions in the cardiovascular system. The present study investigated whether single nucleotide polymorphisms of genes coding cytochrome P450 2C subfamily, enzymes involved in biosynthesis of EETs, are associated with the risk of coronary heart diseas
Matrix metalloproteinases as target genes for gene regulatory networks driving molecular and cellular pathways related to a multistep pathogenesis of cerebrovascular disease
The present study investigated a joint contribution of matrix metalloproteinases (MMPs) genes to ischemic stroke (IS) development and analyzed interactions between MMP genes and genome‐wide associated loci for IS. A total of 1288 unrelated Russians (600 IS patients and 688 healthy individuals) from Central Russia were recruited for the stud
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