6,970 research outputs found
Antigen depot is not required for alum adjuvanticity
Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation and subsequent T- and B-cell responses, this has never been formally proven. To examine antigen persistence, we used the chimeric fluorescent protein EαGFP, which allows assessment of antigen presentation in situ, using the Y-Ae antibody. We demonstrate that alum and/or CpG adjuvants induced similar uptake of antigen, and in all cases, GFP signal did not persist beyond 24 h in draining lymph node antigen-presenting cells. Antigen presentation was first detectable on B cells within 6–12 h of antigen administration, followed by conventional dendritic cells (DCs) at 12–24 h, then finally plasmacytoid DCs at 48 h or later. Again, alum and/or CpG adjuvants did not have an effect on the magnitude or sequence of this response; furthermore, they induced similar antigen-specific T-cell activation in vivo. Notably, removal of the injection site and associated alum depot, as early as 2 h after administration, had no appreciable effect on antigen-specific T- and B-cell responses. This study clearly rules out a role for depot formation in alum adjuvant activity
Variational Density Matrix Method for Warm Condensed Matter and Application to Dense Hydrogen
A new variational principle for optimizing thermal density matrices is
introduced. As a first application, the variational many body density matrix is
written as a determinant of one body density matrices, which are approximated
by Gaussians with the mean, width and amplitude as variational parameters. The
method is illustrated for the particle in an external field problem, the
hydrogen molecule and dense hydrogen where the molecular, the dissociated and
the plasma regime are described. Structural and thermodynamic properties
(energy, equation of state and shock Hugoniot) are presented.Comment: 26 pages, 13 figures. submitted to Phys. Rev. E, October 199
How do liquids confined at the nanoscale influence adhesion?
Liquids play an important role in adhesion and sliding friction. They behave
as lubricants in human bodies especially in the joints. However, in many
biological attachment systems they acts like adhesives, e.g. facilitating
insects to move on ceilings or vertical walls. Here we use molecular dynamics
to study how liquids confined at the nanoscale influence the adhesion between
solid bodies with smooth and rough surfaces. We show that a monolayer of liquid
may strongly affect the adhesion.Comment: 5 pages, 9 color figures. Some figures are in Postscript Level 3
format. Minimal changes with respect to the previous version. Added doi and
reference to the published article also inside the pape
The EXOSAT medium-energy slew survey catalog
We present a catalog of X-ray sources observed during slew maneuvers by the
Medium Energy Detector Array onboard the EXOSAT Observatory. The EXOSAT Medium
Energy slew-survey catalog (EXMS) provides a unique record of the 1--8 keV
X-ray sky between 1983 and 1986. 98% of the sky was observed, with 85%
receiving an exposure of >60 s. 1210 sources were detected. By comparing these
source positions with other catalogs, identifications are given for 992
detections (82% of the sample). These identifications consist of 250 distinct
objects, including 95 different X-ray binary systems, and 14 different AGN. A
further 58 detections have multiple candidates, while 160 detections remain
unidentified. Collimator transmission corrected 1-8 keV count rates are given
for the identified sources, together with raw count rates for the other
detections. The construction of the EXMS and the checks performed to ensure the
validity of the derived source properties are discussed. A publically available
version of this catalog is maintained on the EXOSAT database and archive system
(telnet://[email protected]).Comment: 52 pages. 22 Figures. To be published in A&AS. For more information,
see http://astro.estec.esa.nl/SA-general/Projects/Exosat/exmsintro.htm
Lowering of the Kinetic Energy in Interacting Quantum Systems
Interactions never lower the ground state kinetic energy of a quantum system.
However, at nonzero temperature, where the system occupies a thermal
distribution of states, interactions can reduce the kinetic energy below the
noninteracting value. This can be demonstrated from a first order weak coupling
expansion. Simulations (both variational and restricted path integral Monte
Carlo) of the electron gas model and dense hydrogen confirm this and show that
in contrast to the ground state case, at nonzero temperature the population of
low momentum states can be increased relative to the free Fermi distribution.
This effect is not seen in simulations of liquid He-3.Comment: 4 pages, 5 figures, submitted to Phys. Rev. Lett., June, 200
Radio-frequency dressed lattices for ultracold alkali atoms
Ultracold atomic gases in periodic potentials are powerful platforms for exploring quantum physics in regimes dominated by many-body effects as well as for developing applications that benefit from quantum mechanical effects. Further advances face a range of challenges including the realization of potentials with lattice constants smaller than optical wavelengths as well as creating schemes for effective addressing and manipulation of single sites. In this paper we propose a dressed-based scheme for creating periodic potential landscapes for ultracold alkali atoms with the capability of overcoming such difficulties. The dressed approach has the advantage of operating in a low-frequency regime where decoherence and heating effects due to spontaneous emission do not take place. These results highlight the possibilities of atom-chip technology in the future development of quantum simulations and quantum technologies, and provide a realistic scheme for starting such an exploration
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