Unfolding and unzipping of single-stranded DNA by stretching

We present a theoretical study of single-stranded DNA under stretching. Within the proposed framework, the effects of basepairing on the mechanical response of the molecule can be studied in combination with an arbitrary underlying model of chain elasticity. In a generic case, we show that the stretching curve of ssDNA exhibits two distinct features: the second-order "unfolding" phase transition, and a sharp crossover, reminiscent of the first-order "unzipping" transition in dsDNA. We apply the theory to the particular cases of Worm-like Chain (WLC) and Freely-Joint Chain (FJC) models, and discuss the universal and model--dependent features of the mechanical response of ssDNA. In particular, we show that variation of the width of the unzipping crossover with interaction strength is very sensitive to the energetics of hairpin loops. This opens a new way of testing the elastic properties of ssDNA.Comment: 7 pages, 4 figures, substantially revised versio

The GSFC scientific data storage problem

Scientific data storage problems of telemetry tape

Holographic Grand Unification

We present a framework for grand unification in which the grand unified symmetry is broken spontaneously by strong gauge dynamics, and yet the physics at the unification scale is described by (weakly coupled) effective field theory. These theories are formulated, through the gauge/gravity correspondence, in truncated 5D warped spacetime with the UV and IR branes setting the Planck and unification scales, respectively. In most of these theories, the Higgs doublets arise as composite states of strong gauge dynamics, corresponding to degrees of freedom localized to the IR brane, and the observed hierarchies of quark and lepton masses and mixings are explained by the wavefunction profiles of these fields in the extra dimension. We present several realistic models in this framework. We focus on one in which the doublet-triplet splitting of the Higgs fields is realized within the dynamical sector by the pseudo-Goldstone mechanism, with the associated global symmetry corresponding to a bulk gauge symmetry in the 5D theory. Alternatively, the light Higgs doublets can arise as a result of dynamics on the IR brane, without being accompanied by their triplet partners. Gauge coupling unification and proton decay can be studied in these models using higher dimensional effective field theory. The framework also sets a stage for further studies of, e.g., proton decay, fermion masses, and supersymmetry breaking

Constraints on filament models deduced from dynamical analysis

The conclusions deduced from simultaneous observations with the Ultra-Violet Spectrometer and Polarimeter (UVSP) on the Solar Maximum Mission satellite, and the Multichannel Subtractive Double Pass (MSPD) spectrographs at Meudon and Pic du Midi observatories are presented. The observations were obtained in 1980 and 1984. All instruments have almost the same field of view and provide intensity and velocity maps at two temperatures. The resolution is approx. 0.5 to 1.5" for H alpha line and 3" for C IV. The high resolution and simultaneity of the two types of observations allows a more accurate description of the flows in prominences as functions of temperature and position. The results put some contraints on the models and show that dynamical aspects must be taken into account

Exons, introns and DNA thermodynamics

The genes of eukaryotes are characterized by protein coding fragments, the exons, interrupted by introns, i.e. stretches of DNA which do not carry any useful information for the protein synthesis. We have analyzed the melting behavior of randomly selected human cDNA sequences obtained from the genomic DNA by removing all introns. A clear correspondence is observed between exons and melting domains. This finding may provide new insights in the physical mechanisms underlying the evolution of genes.Comment: 4 pages, 8 figures - Final version as published. See also Phys. Rev. Focus 15, story 1

Phase transition in a non-conserving driven diffusive system

An asymmetric exclusion process comprising positive particles, negative particles and vacancies is introduced. The model is defined on a ring and the dynamics does not conserve the number of particles. We solve the steady state exactly and show that it can exhibit a continuous phase transition in which the density of vacancies decreases to zero. The model has no absorbing state and furnishes an example of a one-dimensional phase transition in a homogeneous non-conserving system which does not belong to the absorbing state universality classes

Higgs Boson Decays to Neutralinos in Low-Scale Gauge Mediation

We study the decays of a standard model-like MSSM Higgs boson to pairs of neutralinos, each of which subsequently decays promptly to a photon and a gravitino. Such decays can arise in supersymmetric scenarios where supersymmetry breaking is mediated to us by gauge interactions with a relatively light gauge messenger sector (M_{mess} < 100 TeV). This process gives rise to a collider signal consisting of a pair of photons and missing energy. In the present work we investigate the bounds on this scenario within the minimal supersymmetric standard model from existing collider data. We also study the prospects for discovering the Higgs boson through this decay mode with upcoming data from the Tevatron and the LHC.Comment: 18 pages, 5 figures, added references and discussion of neutralino couplings, same as journal versio