PROFIBUS-Plug and Play - Adaptive Master- und Slavegeraete fuer selbstkonfigurierende Feldbus-Netzwerke Abschlussbericht

Available from TIB Hannover: RR 7888(15) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Wirtschaft, Bonn (Germany); Arbeitsgemeinschaft Industrieller Forschungsvereinigungen 'Otto von Guericke' e.V. (AIF), Koeln (Germany)DEGerman

Internet zum Feldgeraet - Offene Internet-API unter Beruecksichtigung der Echtzeitbedingungen in der Feldtechnik Uneingeschraenkte Connectivity fuer die Automatisierungstechnik. Abschlussbericht

Available from TIB Hannover: RR 7888(18) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEStiftung Industrieforschung, Koeln (Germany)DEGerman

Portierbare Schicht 7: Implementierung fuer den PROFIBUS als Sensorbus Abschlussbericht

Available from TIB Hannover: RR 7888(2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Wirtschaft, Bonn (Germany); Arbeitsgemeinschaft Industrieller Forschungsvereinigungen e.V., Koeln (Germany)DEGerman

Characterization of newborns with nonimmune hydrops fetalis admitted to a neonatal intensive care unit Caracterização dos recém-nascidos com hidropisia fetal não imune admitidos em uma unidade neonatal de terapia intensiva

PURPOSE: To determine the incidence and characteristics of nonimmune hydrops fetalis in the newborn population. METHOD: A retrospective study of the period between 1996 and 2000, including all newborns with a prenatal or early neonatal diagnosis of nonimmune hydrops fetalis, based on clinical history, physical examination, and laboratory evaluation. The following were analyzed: prenatal follow-up, delivery type, gender, birth weight, gestational age, presence of perinatal asphyxia, nutritional classification, etiopathic diagnosis, length of hospital stay, mortality, and age at death. RESULTS: A total of 47 newborns with hydrops fetalis (0.42% of live births), 18 (38.3%) with the immune form and 29 (61.7%) with the nonimmune form, were selected for study. The incidence of nonimmune hydrops fetalis was 1 per 414 neonates. Data was obtained from 21 newborns, with the following characteristics: 19 (90.5%) were suspected from prenatal diagnosis, 18 (85.7%) were born by cesarean delivery, 15 (71.4%) were female, and 10 (47.6%) were asphyxiated. The average weight was 2665.9 g, and the average gestational age was 35 3/7 weeks; 14 (66.6%) were preterm; 18 (85.0 %) appropriate delivery time; and 3 (14.3%) were large for gestational age. The etiopathic diagnosis was determined for 62%, which included cardiovascular (19.0%), infectious (9.5%), placental (4.8%), hematologic (4.7%), genitourinary (4.8%), and tumoral causes (4.8%), and there was a combination of causes in 9.5%. The etiology was classified as idiopathic in 38%. The length of hospital stay was 26.6 &plusmn; 23.6 days, and the mortality rate was 52.4%. CONCLUSIONS: The establishment of a suitable etiopathic diagnosis associated with prenatal detection of nonimmune hydrops fetalis can be an important step in reducing the neonatal mortality rate from this condition.<br>OBJETIVOS: Determinar a incidência e caracterizar a população de recém-nascidos com hidropisia fetal não imune. MÉTODO: Estudo retrospectivo, referente ao período de 1996 a 2000, incluindo todos os recém-nascidos com diagnóstico antenatal ou neonatal, com base na história clínica, exame físico e avaliação laboratorial. Foram analisados: seguimento pré-natal, tipo de parto, sexo, peso de nascimento, idade gestacional, presença de asfixia perinatal, classificação nutricional, diagnóstico etiopatogênico, tempo de internação, mortalidade, idade do óbito. RESULTADOS: Foram selecionados 47 recém-nascidos com hidropisia fetal (0,42% dos nascidos vivos), 18 (38,3%) com a forma imune e 29(61,7%) com a não imune. A incidência de hidropisia fetal não imune foi de 1:414 nascidos vivos. Obtiveram-se dados de 21 recém-nascidos destes, 19 (90,5%) apresentavam suspeita diag nostico antenatal, 18 (85,7%) nasceram de parto cesariano; 15 (71,4%) eram do sexo feminino; 10 (47,6%) foram asfixiados. O peso médio foi 2665,9g, e a idade gestacional média de 35 3/7 sem, 14 (66,6%) pré-termo; 18 (85,7%) adequados e 3 (14,3%) grandes para idade gestacional. O diagnóstico etiopatogênico foi realizado em 62% dos recém-nascidos, sendo decorrente de causas cardiovasculares (19%), infecciosas (9,5%), placentária (4,76%), hematológicas (4,76,%), gênito-urinária (4,76%), tumoral (4,76%) e houve associação de causas em 9,5%. A etiologia foi classificada em idiopática em 38%. O tempo de internação foi de 26,6 dias &plusmn; 23,6 e a mortalidade de 52,4%. CONCLUSÕES: O estabelecimento de um correto diagnóstico etiopatogênico, associado à detecção antenatal da hidropisia fetal não imune, constitui elemento importante para uma redução da mortalidade neonatal decorrente desta grave doença

High positive predictive value (PPV) of cell-free DNA (cfDNA) testing in a clinical study of 10,000 consecutive pregnancies

Background: Cell-free DNA (cfDNA) analysis in maternal blood for the detection of fetal Down syndrome is gradually replacing first trimester screening. We present here a large clinical series of 10,000 consecutive pregnancies. Objectives: To study the reliability of cell-free DNA (cfDNA) analysis in maternal blood for the detection of fetal trisomy 21, 18 and 13 in a clinical setting in 10,000 consecutive pregnancies with variable risk. cfDNA testing has been evaluated in an increasing number of pregnancies mainly at high risk for fetal trisomy, and some studies have suggested that its positive predictive value (PPV) might be lower in low-risk populations. Study design: CfDNA testing using the Harmony™ Prenatal Test was performed in 10,000 consecutive pregnancies with high or low a-priori risk for fetal trisomy 21, 18 and 13. Results: In 147 (1.47%) of the 10,000 pregnancies a high-risk cfDNA testing result indicated trisomy 21 (n=121), trisomy 18 (n=15) or trisomy 13 (n=11). It failed to detect 5 trisomies (2 trisomies 21, 2 trisomies 18, and 1 trisomy 13). Five false-positive results were recorded (4 in the high and 1 in the low risk population). The overall positive predictive value (PPV) was 96%, with a PPV of 96% in the high-risk (>1/200) population and 97% in the low risk (<1/200) population. Conclusions: In this large clinical series of 10,000 consecutive pregnancies, cfDNA testing proved very reliable in detecting fetal trisomy 21, 18 and 13, with a very high PPV both in high and low risk populations