13 research outputs found
Precision-microfabricated fiber-optic probe for intravascular pressure and temperature sensing
Small form-factor sensors are widely used in minimally invasive intravascular diagnostic procedures. Manufacturing complexities associated with miniaturizing current fiber-optic probes, particularly for multi-parameter sensing, severely constrain their adoption outside of niche fields. It is especially challenging to rapidly prototype and iterate upon sensor designs to optimize performance for medical devices. In this work, a novel technique to construct a microscale extrinsic fiber-optic sensor with a confined air cavity and sub-micron geometric resolution is presented. The confined air cavity is enclosed between a 3 μm thick pressure-sensitive distal diaphragm and a proximal temperature-sensitive plano-convex microlens segment unresponsive to changes in external pressure. Simultaneous pressure and temperature measurements are possible through optical interrogation via phase-resolved low-coherence interferometry(LCI). Upon characterization in a simulated intravascular environment, we find these sensors capable of detecting pressure changes down to 0.11 mmHg (in the range of 760 to 1060 mmHg) and temperature changes of 0.036°C (in the range 34 to 50°C). By virtue of these sensitivity values suited to intravascular physiological monitoring, and the scope of design flexibility enabled by the precision-fabricated photoresist microstructure, it is envisaged that this technique will enable construction of a wide range of fiber-optic sensors for guiding minimally invasive medical procedures
Optical fiber laser ultrasound transmitter with electrospun composite for minimally invasive medical imaging
We report an optical fiber ultrasound transmitter with electrospun MWCNT-polymer composite,
generating high-amplitude broadband ultrasound. They produced pressures in the range of conventional
intravascular imaging transducers, and can be incorporated into catheters/needles for keyhole surgery
Optical fiber ultrasound transmitter with electrospun carbon nanotube-polymer composite
All-optical ultrasound transducers are promising for imaging applications in minimally invasive surgery. In these devices, ultrasound is transmitted and received through laser modulation, and they can be readily miniaturized using optical fibers for light delivery. Here, we report optical ultrasound transmitters fabricated by electrospinning an absorbing polymer composite directly onto the end-face of optical fibers. The composite coating consisting of an aqueous dispersion of multi-walled carbon nanotubes (MWCNTs) in polyvinyl alcohol was directly electrospun onto the cleaved surface of a multimode optical fiber and subsequently dip-coated with polydimethylsiloxane (PDMS). This formed a uniform nanofibrous absorbing mesh over the optical fiber end-face wherein the constituent MWCNTs were aligned preferentially along individual nanofibers. Infiltration of the PDMS through this nanofibrous mesh onto the underlying substrate was observed and the resulting composites exhibited high optical absorption (>97%). Thickness control from 2.3āĪ¼m to 41.4āĪ¼m was obtained by varying the electrospinning time. Under laser excitation with 11āĪ¼J pulse energy, ultrasound pressures of 1.59āMPa were achieved at 1.5āmm from the coatings. On comparing the electrospun ultrasound transmitters with a dip-coated reference fabricated using the same constituent materials and possessing identical optical absorption, a five-fold increase in the generated pressure and wider bandwidth was observed. The electrospun transmitters exhibited high optical absorption, good elastomer infiltration, and ultrasound generation capability in the range of pressures used for clinical pulse-echo imaging. All-optical ultrasound probes with such transmitters fabricated by electrospinning could be well-suited for incorporation into catheters and needles for diagnostics and therapeutic applications
Influence of Lithium and Lanthanum Treatment on TiO2 Nanofibers and Their Application in n-i-p Solar Cells
The addition of cations to TiO2 photoelectrodes is routinely accepted as a route to enhance the performance of conventional nāiāp solar cells. However, this is typically achieved in multiple steps or by the incorporation of expensive and hydroscopic cationic precursors such as lithium bis(trifluoromethanesulfonyl)imide. In addition, it is often unclear as to whether the incorporation of such cation sources is inducing ādopingā or simply transformed into cationic oxides on the surface of the photoelectrodes. In this study, TiO2 nanofibers were produced through a simple electrospinning technique and modified by introducing lithium and lanthanum precursors in one step. Our results show that the addition of both cations caused minimal substitutional or interstitial doping of TiO2. BrunauerāEmmettāTeller measurements showed that lanthanumātreated TiO2 nanofibers had an increase in surface area, which even exceeded that of TiO2 P25 nanoparticles. Finally, treated and untreated TiO2 nanofibers were used in nāiāp solar cells. Photovoltaic characteristics revealed that lanthanum treatment was beneficial, whereas lithium treatment was found to be detrimental to the device performance for both dyeāsensitized and perovskite solar cells. The results discuss new fundamental understandings for two of the commonly incorporated cationic dopants in TiO2 photoelectrodes, lithium and lanthanum, and present a significant step forward in advancing the field of materials chemistry for photovoltaics
Micron resolution, high-fidelity three-dimensional vascular optical imaging phantoms
Microscopic and mesoscale optical imaging techniques allow for three-dimensional (3-D) imaging of biological tissue across millimeter-scale regions, and imaging phantom models are invaluable for system characterization and clinical training. Phantom models that replicate complex 3-D geometries with both structural and molecular contrast, with resolution and lateral dimensions equivalent to those of imaging techniques (<20āāĪ¼m), have proven elusive. We present a method for fabricating phantom models using a combination of two-photon polymerization (2PP) to print scaffolds, and microinjection of tailored tissue-mimicking materials to simulate healthy and diseased tissue. We provide a first demonstration of the capabilities of this method with intravascular optical coherence tomography, an imaging technique widely used in clinical practice. We describe the design, fabrication, and validation of three types of phantom models: a first with subresolution wires (5- to 34-Ī¼m diameter) arranged circumferentially, a second with a vessel side-branch, and a third containing a lipid inclusion within a vessel. Silicone hybrid materials and lipids, microinjected within a resin framework created with 2PP, served as tissue-mimicking materials that provided realistic optical scattering and absorption. We demonstrate that optical phantom models made with 2PP and microinjected tissue-mimicking materials can simulate complex anatomy and pathology with exquisite detail
Polydimethylsiloxane (PDMS) composites for optical ultrasound generation and multi-modality imaging
Polydimethylsiloxane (PDMS) is widely used in biomedical science and can form composites that have broad applicability. One promising application where PDMS composites offer several advantages is optical ultrasound generation via the photoacoustic effect. Here, methods to create these PDMS composites are reviewed and classified. It is highlighted how the composites can be applied to a range of substrates, from micrometerāscale, temperatureāsensitive optical fibers to centimeterāscale curved and planar surfaces. The resulting composites have enabled allāoptical ultrasound imaging of biological tissues both ex vivo and in vivo, with high spatial resolution and with clinically relevant contrast. In addition, the first 3D allāoptical pulseāecho ultrasound imaging of ex vivo human tissue, using a PDMSāmultiwalled carbon nanotube composite and a fiberāoptic ultrasound receiver, is presented. Gold nanoparticleāPDMS and crystal violetāPDMS composites with prominent absorption at one wavelength range for pulseāecho ultrasound imaging and transmission at a second wavelength range for photoacoustic imaging are also presented. Using these devices, images of diseased human vascular tissue with both structural and molecular contrast are obtained. With a broader perspective, literature on recent advances in PDMS microfabrication from different fields is highlighted, and methods for incorporating them into new generations of optical ultrasound generators are suggested
Influence of lithium and lanthanum treatment on TiO2 nanofibers and their application in nāiāp solar cells
The addition of cations to TiO2 photoelectrodes is routinely accepted as a route to enhance the performance of conventional nāiāp solar cells. However, this is typically achieved in multiple steps or by the incorporation of expensive and hydroscopic cationic precursors such as lithium bis(trifluoromethanesulfonyl)imide. In addition, it is often unclear as to whether the incorporation of such cation sources is inducing ādopingā or simply transformed into cationic oxides on the surface of the photoelectrodes. In this study, TiO2 nanofibers were produced through a simple electrospinning technique and modified by introducing lithium and lanthanum precursors in one step. Our results show that the addition of both cations caused minimal substitutional or interstitial doping of TiO2. BrunauerāEmmettāTeller measurements showed that lanthanumātreated TiO2 nanofibers had an increase in surface area, which even exceeded that of TiO2 P25 nanoparticles. Finally, treated and untreated TiO2 nanofibers were used in nāiāp solar cells. Photovoltaic characteristics revealed that lanthanum treatment was beneficial, whereas lithium treatment was found to be detrimental to the device performance for both dyeāsensitized and perovskite solar cells. The results discuss new fundamental understandings for two of the commonly incorporated cationic dopants in TiO2 photoelectrodes, lithium and lanthanum, and present a significant step forward in advancing the field of materials chemistry for photovoltaics