Multimodality imaging for myocardial injury in acute myocardial infarction and the assessment of valvular heart disease

In this PhD thesis we have studied left ventricular systolic deformation with novel cardiovascular magnetic resonance (CMR) algorithm called feature-tracking in patients with acute myocardial infarction (MI). We have shown that left ventricular strain with feature-tracking CMR offers an incremental value above conventional imaging parameters in the assessment of prognosis of patients with acute MI. In addition, left ventricular strain analysis confirmed a clear clinical benefit of early intravenous betablocker treatment in patients with acute MI. Moreover, we have explored the feasibility of novel automated 3D echocardiographic algorithm in the assessment of the aortic root anatomy in patients with severe aortic stenosis prior to transcatheter aortic valve replacement (TAVR). The 3D echocardiographic algorithm performed excellent against the gold standard multidetector row computed tomography to determine the aortic annulus size and to choose the correct TAVR prosthesis size; however, the accuracy was a bit lower in patients with severely calcified aortic valves. In addition, we have explored the advantages and limitations of different cardiac imaging techniques in the assessment of patients with TAVR, the role of multimodality imaging in patients with combined valvular heart disease and heart failure, and the role of myocardial fibrosis assessment with CMR in valvular heart disease.Dutch Heart FoundationLUMC / Geneeskund

Cardiovascular magnetic resonance imaging to assess myocardial fibrosis in valvular heart disease

Cardiolog

Left Ventricular Mechanical Dispersion and Global Longitudinal Strain and Ventricular Arrhythmias in Predialysis and Dialysis Patients

Cardiolog

Effect of Aging on Left Atrial Compliance and Electromechanical Properties in Subjects Without Structural Heart Disease

Cardiolog

Influence of the Quantity of Aortic Valve Calcium on the Agreement Between Automated 3-Dimensional Transesophageal Echocardiography and Multidetector Row Computed Tomography for Aortic Annulus Sizing

Cardiolog

Transcatheter Mitral Valve Replacement for Degenerated Bioprosthetic Valves and Failed Annuloplasty Rings

Cardiolog

Focal Replacement and Diffuse Fibrosis in Primary Mitral Regurgitation A New Piece to the Puzzle

most frequent valvular heart diseases. The most common etiology of primary MR is the myxomatous degeneration of the mitral valve, encompassing fibroelastic deficiency and Barlow's disease. In severe chronic primary MR, the presence of symptoms, reduced left ventricular ejection fraction (LVEF) #60%, and increased left ventricular (LV) end-systolic diameter are indications for mitral valve repair (1,2). In asymptomatic patients, surgery should be considered if there is a high likelihood of durable mitral valve repair; low operative risk; and atrial fibrillation, pulmonary hypertension, flail leaflet, or dilated left atrium at sinus rhythm (1,2). The evidence showing the benefits of early surgery is accumulating. Data from a large cohort of 1,512 patients undergoing mitral valve surgery for isolated primary MR revealed that patients who were operated based only on high likelihood of successful mitral valve repair had the best outcome (3). The rationale for an early intervention is that the longstanding volume overload caused by severe MR may lead to irreversible LV dysfunction. LVEF is considered the parameter of reference to define LV function and toCardiolog

Transcatheter Aortic Valve Replacement: Advantages and Limitations of Different Cardiac Imaging Techniques

Cardiolog

Sudden Cardiac Death Risk Prediction: The Role of Cardiac Magnetic Resonance' Imaging

Cardiolog

AGE DIFFERENCES IN ELECTROMECHANICAL PROPERTIES OF THE LEFT ATRIUM ASSESSED WITH ADVANCED ECHOCARDIOGRAPHY IN PATIENTS WITH NO STRUCTURAL HEART DISEASE

Cardiolog