Evaluation of the neurotoxical effect of aluminum on the Wistar rat

Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of aluminum on neurons, and compared it with a control group. We conclude that spectral analysis and the ratio between the delta and theta ranges might be reliable for a qualitative description of the neurotoxic effect of aluminum, and that the t test might be used to evaluate the change in brain activity between the treated and control groups of animals. The animal model under anesthesia was used to describe the state of brain activity with neurotoxicity with suppressed functional connectivity in the brain structure. We also performed fractal analysis to quantitatively describe neurotoxic effect in different pathophysiological states of animals treated with different doses of aluminum. A decrease in the fractal dimension is an indicator of neurodegeneration in the state of stress. This animal model is suitable for evaluation of the neurodegenerative processes in Alzheimer's dementia and Parkinson's disease.Prethodna istraživanja na animalnom modelu neurotoksičnosti aluminijuma pokazuju da povećanje spektralne snage u delta opsegu je indikator neurotoksičnosti. U ovoj studiji smo koristili nekoliko životinja koje su pogodne za procenu neurotoksičnog efekta aluminijuma u poređenju sa kontrolom. Za kvalitativni opis neurotoksičnosti koristili smo odnos delta i teta opsega i t test za opis promene između tretiranih i kontrolnih pacova. Korišćen je animalni model u uslovima anestezije je opis moždane aktivnosti sa suprimiranim funkcionalnim vezama između moždanih struktura. Koristili smo i fraktalnu dimenziju za kvantitativni opis neurotoksičnog efekta u različitim patofiziološkim stanjima. Smanjenje fraktalne dimenzije je izraz neurodegeneracije u uslovima stresa. Ovaj model je komparabilan sa neurodegenerativnim i neurotransmiterskim promenama u Alchejmerovoj bolesti i Parkinsonovoj bolesti.Projekat ministarstva br. 14302

Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation

Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls

Evaluation of the neurotoxical effect of aluminum on the Wistar rat

Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of aluminum on neurons, and compared it with a control group. We conclude that spectral analysis and the ratio between the delta and theta ranges might be reliable for a qualitative description of the neurotoxic effect of aluminum, and that the t test might be used to evaluate the change in brain activity between the treated and control groups of animals. The animal model under anesthesia was used to describe the state of brain activity with neurotoxicity with suppressed functional connectivity in the brain structure. We also performed fractal analysis to quantitatively describe neurotoxic effect in different pathophysiological states of animals treated with different doses of aluminum. A decrease in the fractal dimension is an indicator of neurodegeneration in the state of stress. This animal model is suitable for evaluation of the neurodegenerative processes in Alzheimer's dementia and Parkinson's disease.Prethodna istraživanja na animalnom modelu neurotoksičnosti aluminijuma pokazuju da povećanje spektralne snage u delta opsegu je indikator neurotoksičnosti. U ovoj studiji smo koristili nekoliko životinja koje su pogodne za procenu neurotoksičnog efekta aluminijuma u poređenju sa kontrolom. Za kvalitativni opis neurotoksičnosti koristili smo odnos delta i teta opsega i t test za opis promene između tretiranih i kontrolnih pacova. Korišćen je animalni model u uslovima anestezije je opis moždane aktivnosti sa suprimiranim funkcionalnim vezama između moždanih struktura. Koristili smo i fraktalnu dimenziju za kvantitativni opis neurotoksičnog efekta u različitim patofiziološkim stanjima. Smanjenje fraktalne dimenzije je izraz neurodegeneracije u uslovima stresa. Ovaj model je komparabilan sa neurodegenerativnim i neurotransmiterskim promenama u Alchejmerovoj bolesti i Parkinsonovoj bolesti.Projekat ministarstva br. 14302

Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation

Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls.Izlaganje dejstvu aluminijuma tokom gestacije i laktacije može dovesti do promena u razviću mozga i ponašanja kod sisara. Naš cilj je bio da se uradi spektralna analiza elektrokortikalne aktivnosti mladih Sprague Dawley pacova muškog pola (starosti 30±3 dana) čije su majke bile tretirane aluminijumom tokom gestacije i laktacije. U poređenju sa kontrolom, kod mladih pacova koji su bili indirektno trovani aluminijumom (čije su majke pile 0,5 % vodeni rastvor AlCl3 tokom gestacionog i laktacionog perioda) postoji veća zastupljenost delta ritma aktivnosti kore velikog mozga, manje prisustvo teta ritma, kao i porast parametra DT kao odnos između delta i teta opsega.Projekat ministarstva br. 14302

Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation

Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls.Izlaganje dejstvu aluminijuma tokom gestacije i laktacije može dovesti do promena u razviću mozga i ponašanja kod sisara. Naš cilj je bio da se uradi spektralna analiza elektrokortikalne aktivnosti mladih Sprague Dawley pacova muškog pola (starosti 30±3 dana) čije su majke bile tretirane aluminijumom tokom gestacije i laktacije. U poređenju sa kontrolom, kod mladih pacova koji su bili indirektno trovani aluminijumom (čije su majke pile 0,5 % vodeni rastvor AlCl3 tokom gestacionog i laktacionog perioda) postoji veća zastupljenost delta ritma aktivnosti kore velikog mozga, manje prisustvo teta ritma, kao i porast parametra DT kao odnos između delta i teta opsega.Projekat ministarstva br. 14302

DOI:10.2298/ABS1003585M EVALUATION OF THE NEUROTOXICAL EFFECT OF ALUMINUM ON THE WISTAR RAT

Abstract- Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of aluminum on neurons, and compared it with a control group. We conclude that spectral analysis and the ratio between the delta and theta ranges might be reliable for a qualitative description of the neurotoxic effect of aluminum, and that the t test might be used to evaluate the change in brain activity between the treated and control groups of animals. The animal model under anesthesia was used to describe the state of brain activity with neurotoxicity with suppressed functional connectivity in the brain structure. We also performed fractal analysis to quantitatively describe neurotoxic effect in different pathophysiological states of animals treated with different doses of aluminum. A decrease in the fractal dimension is an indicator of neurodegeneration in the state of stress. This animal model is suitable for evaluation of the neurodegenerative processes in Alzheimer’s dementia and Parkinson’s disease

Spectral changes of brain activity in rat offspring exposed to aluminium during gestation and lactation

Exposure to aluminium during gestation causes changes in mammalian brain development and behavior. Our aim was to perform spectral analysis on electrocortical activity of Sprague Dawley male pups (30±3 days of age) whose mothers were treated with aluminium during gestation and lactation. There was a higher presence of power spectra in the delta range of parietal electrocortical activity, a lower presence in the theta range and increased values of the parameter DT as the ratio of delta to theta range in pups indirectly exposed to aluminium (whose mothers were drinking a 0.5% water solution of aluminium chloride during the gestation and lactation periods), compared to controls