502 research outputs found
Lessons for Legal Education from the Engineering Profession\u27s Experience with Outcomes-based Accreditation
Do radiological research articles apply the term "pilot study" correctly? Systematic review
AIM: To determine what proportion of radiological studies used the term "pilot" correctly. MATERIAL AND METHODS: Indexed studies describing themselves as a "pilot" in their title were identified from four indexed radiological journals. The aim was to identify 20 consecutive, eligible studies from each journal, as this sample size was deemed sufficient to be representative as to how this methodological description was employed by authors of radiological articles. Data were extracted relating to study design and data presented. The review was reported according to PRISMA guidelines. RESULTS: The search string used identified 658 records across the four targeted journals. Ultimately, 78 reviews describing 5,572 patients were selected for systematic review. Median sample size was just 20 patients. No individual study qualified as a genuine pilot study when assessed against the a priori criteria. In reality, the large majority (66 studies, 84.6%) were framed as studies of diagnostic test accuracy. A significant proportion (21 studies, 26.9%) was retrospective, and the overwhelming majority were conducted in single centres (76 centres, 94.7%). Most (55 studies, 70.5%) stated no rationale for their sample size, and no study presented a formal power calculation. CONCLUSION: Radiological "pilot" studies are mostly underpowered studies of diagnostic test accuracy. In order to have scientific credibility, authors, reviewers, and editors of radiological journals are encouraged to familiarise themselves with different methodological study designs and their precise implications
Dynamical Structure Factor of the Three-Dimensional Quantum Spin Liquid Candidate NaCaNi2F7
We study the dynamical structure factor of the spin-1 pyrochlore material NaCaNi2F7, which is well described by a weakly perturbed nearest-neighbour Heisenberg Hamiltonian, Our three approaches- molecular dynamics simulations, stochastic dynamical theory, and linear spin wave theory-reproduce remarkably well the momentum dependence of the experimental inelastic neutron scattering intensity as well as its energy dependence with the exception of the lowest energies. We discuss two surprising aspects and their implications for quantum spin liquids in general: the complete lack of sharp quasiparticle excitations in momentum space and the success of the linear spin wave theory in a regime where it would be expected to fail for several reasons
How to avoid describing your radiological research study incorrectly
This review identifies and examines terms used to describe a radiological research âstudyâ or âtrialâ. A taxonomy of clinical research descriptions is explained with reference to medical imaging examples. Because many descriptive terms have precise methodological implications, it is important that these terms are understood by readers and used correctly by researchers, so that the reader is not misled
Prolonged Refractory Hypotension following Combined Amlodipine and Losartan Ingestion Responsive to Metaraminol
Introduction. Overdose with the calcium channel blocker amlodipine can cause profound hypotension that may be exacerbated by the concurrent ingestion of an angiotensin II receptor antagonist. Best management of such overdoses is uncertain although the use of hyperinsulinaemia-euglycaemia (HIE) has been recommended. Case report. We report a case of mixed amlodipine and losartan overdose in a 50-year-old lady. Severe hypotension was resistant to conventional vasopressors and high-dose insulin/euglycaemia, but did respond to a metaraminol infusion. Conclusion. A trial of metaraminol early in severe cases of calcium channel blocker and angiotensin II receptor antagonist toxicity may be of benefit, especially when conventional ionotropic treatment measures are failing
Observation of Weyl nodes in robust type-II Weyl semimetal WP2
Distinct to type-I Weyl semimetals (WSMs) that host quasiparticles described
by the Weyl equation, the energy dispersion of quasiparticles in type-II WSMs
violates Lorentz invariance and the Weyl cones in the momentum space are
tilted. Since it was proposed that type-II Weyl fermions could emerge from
(W,Mo)Te2 and (W,Mo)P2 families of materials, a large numbers of experiments
have been dedicated to unveil the possible manifestation of type-II WSM, e.g.
the surface-state Fermi arcs. However, the interpretations of the experimental
results are very controversial. Here, using angle-resolved photoemission
spectroscopy supported by the first-principles calculations, we probe the
tilted Weyl cone bands in the bulk electronic structure of WP2 directly, which
are at the origin of Fermi arcs at the surfaces and transport properties
related to the chiral anomaly in type-II WSMs. Our results ascertain that due
to the spin-orbit coupling the Weyl nodes originate from the splitting of
4-fold degenerate band-crossing points with Chern numbers C = 2 induced by
the crystal symmetries of WP2, which is unique among all the discovered WSMs.
Our finding also provides a guiding line to observe the chiral anomaly which
could manifest in novel transport properties.Comment: 13 pages, 3 figure
Trivial topological phase of CaAgP and the topological nodal-line transition in CaAg(P1-xAsx)
By performing angle-resolved photoemission spectroscopy and first-principles
calculations, we address the topological phase of CaAgP and investigate the
topological phase transition in CaAg(P1-xAsx). We reveal that in CaAgP, the
bulk band gap and surface states with a large bandwidth are topologically
trivial, in agreement with hybrid density functional theory calculations. The
calculations also indicate that application of "negative" hydrostatic pressure
can transform trivial semiconducting CaAgP into an ideal topological nodal-line
semimetal phase. The topological transition can be realized by partial
isovalent P/As substitution at x = 0.38.Comment: 20 pages, 4 figure
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