Cycloalkenopyridines by ring transformations of diazines and triazines

This paper is a short review on the synthesis of 2,3-cycloalkenopyridines and 3,4-cycloalkenopyridines by inter- and intra-molecular cycloadditions

Immobiel, maar toch actief

Rede. Landbouwhogeschool. ([no.375]

Modern en klassiek

Rede Wageninge

Different properties of factor VIII in Von Willebrand's disease with respect to recovery in cryoprecipitate

The recovery of factor VIII-activity in cryoprecipitate prepared from plasma from six patients with von Willebrand’s disease was low as compared to the recovery from normal and hemophilia-A plasma. The possible cause is briefly discussed

The influence of the polyene filipin on the extrinsic pathway of blood coagulation

The inhibition by filipin in the extrinsic blood clotting system takes place at two sites: (1) at the interaction of factor VII, tissue thromboplastin and Ca++, and (2) at the prothrombinase level. Both formation and enzymatic activity of the prothrombinase are inhibited.The cholesterol content of the lipid that is used to form the prothrombinase complex determines the degree of inhibition by filipin. The inhibition increases the higher the sterol content. The adsorption of factors Xa and V onto lipid surface is enhanced by filipin. This increased adsorption does not lead to an increase in prothrombinase production

Vicarious nucleophilic substitution of hydrogen vs. ANRORC-type ring transformation in reactions of 1,2,4-triazines with alpha-halocarbanions. Novel route to functionalized pyrazoles

A novel route to pyrazole derivatives bearing sulfonyl, aminosulfonyl, alkoxy- and aryloxysulfonyl groups at C-3 by ring transformation of 3-chloro-6-aryl-1,2,4-triazines 1a-c with alpha-halocarbanions 2a-h is described