Reduced cortical oxygenation predicts a progressive decline of renal function in patients with chronic kidney disease.

Renal tissue hypoxia is a final pathway in the development and progression of chronic kidney disease (CKD), but whether renal oxygenation predicts renal function decline in humans has not been proven. Therefore, we performed a prospective study and measured renal tissue oxygenation by blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in 112 patients with CKD, 47 with hypertension without CKD, and 24 healthy control individuals. Images were analyzed with the twelve-layer concentric objects method that divided the renal parenchyma in 12 layers of equal thickness and reports the mean R2* value of each layer (a high R2* corresponds to low oxygenation), along with the change in R2* between layers called the R2* slope. Serum creatinine values were collected to calculate the yearly change in estimated glomerular function rate (MDRD eGFR). Follow up was three years. The change in eGFR in CKD, hypertensive and control individuals was -2.0, 0.5 and -0.2 ml/min/1.73m <sup>2</sup> /year, respectively. In multivariable regression analysis adjusted for age, sex, diabetes, RAS-blockers, eGFR, and proteinuria the yearly eGFR change correlated negatively with baseline 24 hour proteinuria and the mean R2* value of the cortical layers, and positively with the R2* slope, but not with the other covariates. Patients with CKD and high outer R2* or a flat R2* slope were three times more likely to develop an adverse renal outcome (renal replacement therapy or over a 30% increase in serum creatinine). Thus, low cortical oxygenation is an independent predictor of renal function decline. This finding should stimulate studies exploring the therapeutic impact of improving renal oxygenation on renal disease progression

Probe-configuration dependent dephasing in a mesoscopic interferometer

Dephasing in a ballistic four-terminal Aharonov-Bohm geometry due to charge and voltage fluctuations is investigated. Treating two terminals as voltage probes, we find a strong dependence of the dephasing rate on the probe configuration in agreement with a recent experiment by Kobayashi et al. (J. Phys. Soc. Jpn. 71, 2094 (2002)). Voltage fluctuations in the measurement circuit are shown to be the source of the configuration dependence.Comment: 4 pages, 3 figure

Saturation of dephasing time in mesoscopic devices produced by a ferromagnetic state

We consider an exchange model of itinerant electrons in a Heisenberg ferromagnet and we assume that the ferromagnet is in a fully polarized state. Using the Holstein-Primakoff transformation we are able to obtain a boson-fermion Hamiltonian that is well-known in the interaction between light and matter. This model describes the spontaneous emission in two-level atoms that is the proper decoherence mechanism when the number of modes of the radiation field is taken increasingly large, the vacuum acting as a reservoir. In the same way one can see that the interaction between the bosonic modes of spin waves and an itinerant electron produces decoherence by spin flipping with a rate proportional to the size of the system. In this way we are able to show that the experiments on quantum dots, described in D. K. Ferry et al. [Phys. Rev. Lett. {\bf 82}, 4687 (1999)], and nanowires, described in D. Natelson et al. [Phys. Rev. Lett. {\bf 86}, 1821 (2001)], can be understood as the interaction of itinerant electrons and an electron gas in a fully polarized state.Comment: 10 pages, no figure. Changed title. Revised version accepted for publication in Physical Review

Phase-coherence time saturation in mesoscopic systems: wave function collapse

A finite phase-coherence time $\tau_{\phi}^{meas}$ emerges from iterative measurement onto a quantum system. For a rapid sequence, the phase-coherence time is found explicitly. For the stationary charge conduction problem, it is bounded. At all order, in the time-interval of measurements, we propose a general expression for $\tau_{\phi}^{meas}$.Comment: 8 pages, 0 figures, Late

Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study.

Allostatic load (AL) is a marker of physiological dysregulation which reflects exposure to chronic stress. High AL has been related to poorer health outcomes including mortality. We examine here the association of socioeconomic and lifestyle factors with AL. Additionally, we investigate the extent to which AL is genetically determined. We included 803 participants (52% women, mean age 48±16years) from a population and family-based Swiss study. We computed an AL index aggregating 14 markers from cardiovascular, metabolic, lipidic, oxidative, hypothalamus-pituitary-adrenal and inflammatory homeostatic axes. Education and occupational position were used as indicators of socioeconomic status. Marital status, stress, alcohol intake, smoking, dietary patterns and physical activity were considered as lifestyle factors. Heritability of AL was estimated by maximum likelihood. Women with a low occupational position had higher AL (low vs. high OR=3.99, 95%CI [1.22;13.05]), while the opposite was observed for men (middle vs. high OR=0.48, 95%CI [0.23;0.99]). Education tended to be inversely associated with AL in both sexes(low vs. high OR=3.54, 95%CI [1.69;7.4]/OR=1.59, 95%CI [0.88;2.90] in women/men). Heavy drinking men as well as women abstaining from alcohol had higher AL than moderate drinkers. Physical activity was protective against AL while high salt intake was related to increased AL risk. The heritability of AL was estimated to be 29.5% ±7.9%. Our results suggest that generalized physiological dysregulation, as measured by AL, is determined by both environmental and genetic factors. The genetic contribution to AL remains modest when compared to the environmental component, which explains approximately 70% of the phenotypic variance

Conductance fluctuations and weak localization in chaotic quantum dots

We study the conductance statistical features of ballistic electrons flowing through a chaotic quantum dot. We show how the temperature affects the universal conductance fluctuations by analyzing the influence of dephasing and thermal smearing. This leads us to two main findings. First, we show that the energy correlations in the transmission, which were overlooked so far, are important for calculating the variance and higher moments of the conductance. Second, we show that there is an ambiguity in the method of determination of the dephasing rate from the size of the of the weak localization. We find that the dephasing times obtained at low temperatures from quantum dots are underestimated.Comment: 4 pages, 4 figures, to appear in Phys. Rev. Let

Electron dephasing near zero temperature: an experimental review

The behavior of the electron dephasing time near zero temperature, $\tau_\phi^0$, has recently attracted vigorous attention. This renewed interest is primarily concerned with whether $\tau_\phi^0$ should reach a finite or an infinite value as $T \to$ 0. While it is accepted that $\tau_\phi^0$ should diverge if there exists only electron-electron (electron-phonon) scattering, several recent measurements have found that $\tau_\phi^0$ depends only very weakly on temperature, if at all, when $T$ is sufficiently low. This article discusses the current experimental status of "the saturation problem", and concludes that the origin(s) for this widely observed saturation are still unresolved

Percolation-type description of the metal-insulator transition in two dimensions

A simple non-interacting-electron model, combining local quantum tunneling and global classical percolation (due to a finite dephasing time at low temperatures), is introduced to describe a metal-insulator transition in two dimensions. It is shown that many features of the experiments, such as the exponential dependence of the resistance on temperature on the metallic side, the linear dependence of the exponent on density, the $e^2/h$ scale of the critical resistance, the quenching of the metallic phase by a parallel magnetic field and the non-monotonic dependence of the critical density on a perpendicular magnetic field, can be naturally explained by the model.Comment: 4 pages, 4 figure