Review Essay : The Family and Migration: News From the Frencn

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67023/2/10.1177_036319908601100205.pd

Marriage, Migration, and Urban Demographic Structure: a Case From France in the Belle Epoque

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67248/2/10.1177_036319908100600109.pd

Targeting of T/Tn Antigens with a Plant Lectin to Kill Human Leukemia Cells by Photochemotherapy

Photochemotherapy is used both for solid tumors and in extracorporeal treatment of various hematologic disorders. Nevertheless, its development in oncology remains limited, because of the low selectivity of photosensitizers (PS) towards human tumor cells. To enhance PS efficiency, we recently covalently linked a porphyrin (TrMPyP) to a plant lectin (Morniga G), known to recognize with high affinity tumor-associated T and Tn antigens. The conjugation allowed a quick uptake of PS by Tn-positive Jurkat leukemia cells and efficient PS-induced phototoxicity. The present study was performed: (i) to evaluate the targeting potential of the conjugate towards tumor and normal cells and its phototoxicity on various leukemia cells, (ii) to investigate the mechanism of conjugate-mediated cell death. The conjugate: (i) strongly increased (×1000) the PS phototoxicity towards leukemic Jurkat T cells through an O-glycan-dependent process; (ii) specifically purged tumor cells from a 1∶1 mixture of Jurkat leukemia (Tn-positive) and healthy (Tn-negative) lymphocytes, preserving the activation potential of healthy lymphocytes; (iii) was effective against various leukemic cell lines with distinct phenotypes, as well as fresh human primary acute and chronic lymphoid leukemia cells; (iv) induced mostly a caspase-independent cell death, which might be an advantage as tumor cells often resist caspase-dependent cell death. Altogether, the present observations suggest that conjugation with plant lectins can allow targeting of photosensitizers towards aberrant glycosylation of tumor cells, e.g. to purge leukemia cells from blood and to preserve the normal leukocytes in extracorporeal photochemotherapy

L'Europe du Nord-Ouest. Iles Britanniques et Pays nordiques. Paris, SEDESCDU

Pitié Jean. L'Europe du Nord-Ouest. Iles Britanniques et Pays nordiques. Paris, SEDESCDU. In: Norois, n°115, Juillet-Septembre 1982. p. 472

Rieupeyroux (F.). — Société et vie sociale au Moyen Age

Pitié Jean. Rieupeyroux (F.). — Société et vie sociale au Moyen Age . In: Norois, n°123, Juillet-Septembre 1984. p. 496

Sur quelques rééditions.

Pitié Jean. Sur quelques rééditions.. In: Norois, n°80, Octobre-Décembre 1973. pp. 702-705

Un climat tropical très humide en Charente au début de l'Eocène

Pitié Jean. Un climat tropical très humide en Charente au début de l'Eocène. In: Norois, n°104, Octobre-Décembre 1979. p. 579

Atlas des énergies renouvelables en Poitou-Charentes. Etablissement Public Régional Poitou-Charentes. Commissariat à l'Energie Solaire

Pitié Jean. Atlas des énergies renouvelables en Poitou-Charentes. Etablissement Public Régional Poitou-Charentes. Commissariat à l'Energie Solaire. In: Norois, n°114, Avril-Juin 1982. p. 325

Chauncy D. Harris (Essays in honor of...), 1986. — World Patterns of Modern Urban Change

Pitié Jean. Chauncy D. Harris (Essays in honor of...), 1986. — World Patterns of Modern Urban Change. In: Norois, n°141, Janvier-Mars 1989. pp. 135-136

René Crozet. — Vendée, Marais Poitevin (Collection «La France Illustrée», Editions Alpina, nombreuses photos, 64 pages, Paris, 1953)

Pitié Jean. René Crozet. — Vendée, Marais Poitevin (Collection «La France Illustrée», Editions Alpina, nombreuses photos, 64 pages, Paris, 1953). In: Norois, n°4, Octobre-Décembre 1954. pp. 460-461