Quaternary lithostratigraphic units (Belgium)

The lithostratigraphic classification of the Quatemary deposits is based on the genesis of the sediments. The distinguished environments are marine -estuarine, fluvial, eolian and slope. The marine -estuarine deposits are restricted to certain time-intervals within the Quatemary and are limited to the northern part of Belgium. Fluvial deposits are found throughout the Quatemary. On the basis of the sedimentological -lithological differentials within the Meuse basin and the Schelde basin a bipartite subdivision of the fluvial deposits is introduced. Eolian deposits are differentiated on the basis of their grain size distribution, namely sand and silt. The sandy deposits are accumulated in the northern part of Belgium, whereas loess is deposited in the more southern part of the country. Slope deposits are not restricted regionally neither temporally

Assessment of the Safety of Glucocorticoid Regimens in Combination With Abiraterone Acetate: A Randomized, Open-Label Phase 2 Study

Importance Abiraterone acetate is combined with prednisone, 5 mg, twice daily for metastatic castration-resistant prostate cancer (mCRPC) and with prednisone, 5 mg, once daily for newly diagnosed, high-risk, metastatic castration-sensitive prostate cancer. Understanding the physiological effects of these and other regimens is important. Objective To evaluate the safety of abiraterone acetate with 4 glucocorticoid regimens. Design, Setting, and Participants Open-label, randomized clinical trial (1:1:1:1) of 164 men with mCRPC from 22 hospitals in 5 countries who were randomly assigned to 1 of 4 intervention groups between June 2013 and October 2014. Analyses were conducted from August 2017 to June 2018. Interventions Abiraterone acetate, 1000 mg, once daily with prednisone, 5 mg, twice daily (n = 41), 5 mg once daily (n = 41), 2.5 mg twice daily (n = 40), or dexamethasone, 0.5 mg, once daily (n = 42). Main Outcomes and Measures Primary end point was no mineralocorticoid excess (grade ≥1 hypokalemia or grade ≥2 hypertension) through 24 weeks (6 cycles) from treatment. Results Of 164 men (median [range] age, 70 [50-90] years) randomized to receive abiraterone acetate, 1000 mg, daily with prednisone, 5 mg, twice daily, once daily, or 2.5 mg twice daily, or dexamethasone, 0.5 mg, once daily, 24 (70.6%) of 34 patients (95% CI, 53.8%-83.2%), 14 (36.8%) of 38 patients (95% CI, 23.4%-52.7%), 21 (60.0%) of 35 patients (95% CI, 43.6%-74.4%), and 26 (70.3%) of 37 patients (95% CI, 54.2%-82.5%), respectively, had no mineralocorticoid excess. Plasma adrenocorticotrophic hormone and urinary mineralocorticoid metabolites after 8 weeks were higher with prednisone, 2.5 mg, twice daily and 5 mg once daily than with 5 mg twice daily or dexamethasone, 0.5 mg, once daily. The level of urinary glucocorticoid metabolites appeared higher in patients who did not meet the primary end point, regardless of glucocorticoid regimen. Total lean body mass decreased in the prednisone groups and total body fat increased in the prednisone, 5 mg, twice daily and dexamethasone groups. In the dexamethasone group, there was an increase in serum insulin and homeostatic model assessment of insulin resistance, while total bone mineral density decreased. In the prednisone, 5 mg, twice daily, 5 mg once daily, 2.5 mg twice daily, and dexamethasone groups, median radiographic progression-free survival was 18.5, 15.3, 12.8, and 26.6 months, respectively. Conclusions and Relevance Abiraterone acetate with prednisone, 5 mg, twice daily or dexamethasone, 0.5 mg, once daily met the prespecified threshold for the primary end point (95% CI excluded 50% mineralocorticoid excess); abiraterone acetate with prednisone, 5 mg, once daily or 2.5 mg twice daily did not meet the threshold. Abiraterone acetate in combination with dexamethasone appeared to be particularly active but may be associated with adverse metabolic consequences

Struktur und Alter von Resten periglazialer Hügel im Hohen Venn (Belgien)

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L'érosion des sols limoneux cultivés de la Hesbaye

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Permafrost changes in Europe during the Last Glacial.

Reconstruction of former permafrost is based on specific indicators which represent relics of features developed above or within the permafrost. Their interpretation in terms of genesis and (palaeo)climatic significance, however, is in some cases still under debate. Previously the reconstruction of the periglacial environment in Europe was limited to permafrost mapping during the coldest time of the last glaciation. Today a much more refined evolution of the palaeoclimate of the last glacial has been established, thanks to a considerable increase in registered periglacial indicators, a better understanding of the corresponding climate conditions, and more accurate and reliable dating of the periglacial phenomena. Copyright © 1993 John Wiley & Sons, Lt

The periglacial ramparted depressions of the Hautes Fagnes Plateau: traces of Late Weichselian lithalsas

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L'impact des aménagements récents des rivières wallonnes. Exemples de la Meuse, de l'Ourthe et du Geer

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Fréquence et importance du charriage dans les rivières à charge de fond caillouteuse

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Introduction à la journée d'étude de la société belge de pédologie du 28 octobre 1977 : l'érosion en milieu agricole

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