6 research outputs found
The +299(G>A) Resistin Gene Polymorphism and Susceptibility to Type 2 Diabetes in Thais
The prevalence of type 2 diabetes has been increased in Thais. Resistin is an adipokine that involve in glucose homeostasis and is a candidate gene for type 2 diabetes. We performed a case-control study in representative sample of 200 Thai volunteers, 105 controls and 95 type 2 diabetes subjects. The purposes of the present study were to investigate the association between two SNPs (single nucleotide polymorphisms) in the resistin gene, at positions +299(G>A) and −420(C>G), and biochemical parameters; to determine whether these polymorphisms are linked to increased risk of type 2 diabetes. At position +299(G>A) of the resistin gene, the resistin concentration among type 2 diabetes subjects was significantly higher in GA/AA genotypes (3.40 ng/ml) than the GG genotype (1.99 ng/ml). Resistin gene polymorphism at position +299(G>A) in type 2 diabetes patients was significantly more frequent than in the control group (p = 0.004). Polymorphism at position −420(C>G) showed no significant relationship with type 2 diabetes (p = 0.095). Logistic regression analysis was shown that +299(G>A) gene polymorphism was increased risk factors for type 2 diabetes (p = 0.013). In conclusion, these finding suggest that resistin gene polymorphism at position +299(G>A) has impact on the increased resistin concentrations and may influence susceptibility to type 2 diabetes in Thais
Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais
Background: An oxidant/antioxidant disequilibrium has been suggested as
having a role in the pathogenesis of some diseases. Metabolic syndrome
(MS) is significantly associated with cardiovascular disease and type 2
diabetes. The pathogenesis of MS is complex and not well understood.
The purposes of the present study were to compare enzymatic and
non-enzyme antioxidants, anthropometric, hematological, and biochemical
findings between subjects with MS and without MS and to evaluate the
relationship between antioxidant status and hematological parameters
with the components of MS. Methods: Metabolic syndrome was assessed by
using the modified National Cholesterol Education Program, Adult
Treatment Panel III criteria. Three hundred Thais, 124 with MS and 176
without MS, were included in the study. Each subject was tested for
erythrocyte superoxide dismutase (SOD), glutathione peroxidase, (GPX),
catalase (CAT), albumin and vitamin C levels, and hematological
findings. Results: Subjects with MS had lower SOD and CAT levels than
those without MS (p < 0.01). Subjects with MS had lower vitamin C
and albumin levels than those without MS (p < 0.05). The
hematological findings were not significantly different between those
with and without MS except the white blood cell (WBC) count which was
significantly higher in those with MS. SOD and CAT levels were
significantly positively associated with HDL-C levels and negatively
associated with components of MS. After adjusting for potential
covariates, we found lower SOD and vitamin C levels and higher WBC
counts were significantly associated with MS (p < 0.05).
Conclusions: These findings suggest an alteration in antioxidant status
and an increase in inflammatory markers are associated with MS and its
components among Thais; subjects with MS may be more likely to have
oxidative stress problems
Associations of Resistin Levels with Resistin Gene Polymorphism and Metabolic Syndrome in Thais / Asocijacija Nivoa Rezistina Sa Polimorfizmom Gena Za Rezistin I Metaboličkim Sindromom Kod Tajlanđana
Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais
Abstract Background An oxidant/antioxidant disequilibrium has been suggested as having a role in the pathogenesis of some diseases. Metabolic syndrome (MS) is significantly associated with cardiovascular disease and type 2 diabetes. The pathogenesis of MS is complex and not well understood. The purposes of the present study were to compare enzymatic and non-enzyme antioxidants, anthropometric, hematological, and biochemical findings between subjects with MS and without MS and to evaluate the relationship between antioxidant status and hematological parameters with the components of MS. Methods Metabolic syndrome was assessed by using the modified National Cholesterol Education Program, Adult Treatment Panel III criteria. Three hundred Thais, 124 with MS and 176 without MS, were included in the study. Each subject was tested for erythrocyte superoxide dismutase (SOD), glutathione peroxidase, (GPX), catalase (CAT), albumin and vitamin C levels, and hematological findings. Results Subjects with MS had lower SOD and CAT levels than those without MS (p < 0.01). Subjects with MS had lower vitamin C and albumin levels than those without MS (p < 0.05). The hematological findings were not significantly different between those with and without MS except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potential covariates, we found lower SOD and vitamin C levels and higher WBC counts were significantly associated with MS (p < 0.05). Conclusions These findings suggest an alteration in antioxidant status and an increase in inflammatory markers are associated with MS and its components among Thais; subjects with MS may be more likely to have oxidative stress problems