163 research outputs found
Grid services for the MAGIC experiment
Exploring signals from the outer space has become an observational science
under fast expansion. On the basis of its advanced technology the MAGIC
telescope is the natural building block for the first large scale ground based
high energy gamma-ray observatory. The low energy threshold for gamma-rays
together with different background sources leads to a considerable amount of
data. The analysis will be done in different institutes spread over Europe.
Therefore MAGIC offers the opportunity to use the Grid technology to setup a
distributed computational and data intensive analysis system with the nowadays
available technology. Benefits of Grid computing for the MAGIC telescope are
presented.Comment: 5 pages, 1 figures, to be published in the Proceedings of the 6th
International Symposium ''Frontiers of Fundamental and Computational
Physics'' (FFP6), Udine (Italy), Sep. 26-29, 200
A survey among dermatologists: diagnostics of superficial fungal infections - what is used and what is needed to initiate therapy and assess efficacy?
BACKGROUND: Superficial fungal infections are common. It is important to confirm the clinical diagnosis by mycological laboratory methods before initiating systemic antifungal treatment, especially as antifungal sensitivity and in vitro susceptibility may differ between different genera and species. For many years, the gold standard for diagnosis of superficial fungal infections has been direct fungal detection in the clinical specimen (microscopy) supplemented by culturing. Lately, newer molecular based methods for fungal identification have been developed. OBJECTIVE: This study was initiated to focus on the current usage of mycological diagnostics for superficial fungal infections by dermatologists. It was designed to investigate whether it was necessary to differentiate between initial diagnostic tests and those used at treatment follow-up in specific superficial fungal infections. METHODS: An online questionnaire was distributed among members of the EADV mycology Task Force and other dermatologists with a special interest in mycology and nail disease. RESULTS: The survey was distributed to 62 dermatologists of whom 38 (61%) completed the whole survey, 7 (11%) partially completed and 17 (27%) did not respond. Nearly, all respondents (82-100%) said that ideally they would use the result of direct microscopy (or histology) combined with a genus/species directed treatment of onychomycosis, dermatophytosis, Candida- and Malassezia-related infections. The majority of the dermatologists used a combination of clinical assessment and direct microscopy for treatment assessment and the viability of the fungus was considered more important at this visit than when initiating the treatment. Molecular based methods were not available for all responders. CONCLUSION: The available diagnostic methods are heterogeneous and their usage differs between different practices as well as between countries. The survey confirmed that dermatologists find it important to make a mycological diagnosis, particularly prior to starting oral antifungal treatment in order to confirm the diagnose and target the therapy according to genus and species
Tinea capitis in children: a systematic review of management
Background
Tinea capitis is the most common cutaneous fungal infection in children.
Objectives
This review aims to evaluate the differences that exist between medications for the treatment of tinea capitis, to determine whether there are any significant adverse effects associated and to define the usefulness of sample collection methods.
Methods
We conducted a systematic literature search of available papers using the databases PubMed, OVID, Cochrane Libraries and ClinicalTrials.gov. Twenty‐one RCTs and 17 CTs were found.
Results
Among the different antifungal therapies (oral and combination thereof), continuous itraconazole and terbinafine had the highest mycological cure rates (79% and 81%, respectively), griseofulvin and terbinafine had the highest clinical cure rates (46% and 58%, respectively) and griseofulvin and terbinafine had the highest complete cure rate (72% and 92%, respectively). Griseofulvin more effectively treated Microsporum infections; terbinafine and itraconazole more effectively cured Trichophyton infections. Only 1.0% of children had to discontinue medication based on adverse events. T. tonsurans was the most common organism found in North America, and hairbrush collection method is the most efficient method of sample collection. Additionally, using a hairbrush, toothbrush or cotton swab to identify the infecting organism(s) is the least invasive and most efficient method of tinea capitis sample collection in children.
Conclusions
Current dosing regimens of reported drugs are effective and safe for use in tinea capitis in children
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Proximal subungual onychomycosis due to Aspergillus niger: report of two cases
Hypertrophic verrucous lesions after monkeypox virus infection
Hypertrophic verrucous lesions after monkeypox virus infectio
Onychodynia: a new term of painful sensation and paresthesia of the nails
Onychodynia: a new term of painful sensation and paresthesia of the nail
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