21,822 research outputs found
Monitoring thermal ablation via microwave tomography. An ex vivo experimental assessment
Thermal ablation treatments are gaining a lot of attention in the clinics thanks to their reduced invasiveness and their capability of treating non-surgical patients. The effectiveness of these treatments and their impact in the hospital's routine would significantly increase if paired with a monitoring technique able to control the evolution of the treated area in real-time. This is particularly relevant in microwave thermal ablation, wherein the capability of treating larger tumors in a shorter time needs proper monitoring. Current diagnostic imaging techniques do not provide effective solutions to this issue for a number of reasons, including economical sustainability and safety. Hence, the development of alternative modalities is of interest. Microwave tomography, which aims at imaging the electromagnetic properties of a target under test, has been recently proposed for this scope, given the significant temperature-dependent changes of the dielectric properties of human tissues induced by thermal ablation. In this paper, the outcomes of the first ex vivo experimental study, performed to assess the expected potentialities of microwave tomography, are presented. The paper describes the validation study dealing with the imaging of the changes occurring in thermal ablation treatments. The experimental test was carried out on two ex vivo bovine liver samples and the reported results show the capability of microwave tomography of imaging the transition between ablated and untreated tissue. Moreover, the discussion section provides some guidelines to follow in order to improve the achievable performances
The SUMMIT trial: a field comparison of buprenorphine versus methadone maintenance treatment.
This prospective patient-preference study examined the effectiveness in practice of methadone versus buprenorphine maintenance treatment and the beliefs of subjects regarding these drugs. A total of 361 opiate-dependent individuals (89% of those eligible, presenting for treatment over 2 years at a drug service in England) received rapid titration then flexible dosing with methadone or buprenorphine; 227 patients chose methadone (63%) and 134 buprenorphine (37%). Participants choosing methadone had more severe substance abuse and psychiatric and physical problems but were more likely to remain in treatment. Survival analysis indicated those prescribed methadone were over twice as likely to be retained (hazard ratio for retention was 2.08 and 95% confidence interval [CI] = 1.49-2.94 for methadone vs. buprenorphine), However, those retained on buprenorphine were more likely to suppress illicit opiate use (odds ratio = 2.136, 95% CI = 1.509-3.027, p < .001) and achieve detoxification. Buprenorphine may also recruit more individuals to treatment because 28% of those choosing buprenorphine (10% of the total sample) stated they would not have accessed treatment with methadone
High-fidelity simulations of the lobe-and-cleft structures and the deposition map in particle-driven gravity currents
Recording from two neurons: second order stimulus reconstruction from spike trains and population coding
We study the reconstruction of visual stimuli from spike trains, recording
simultaneously from the two H1 neurons located in the lobula plate of the fly
Chrysomya megacephala. The fly views two types of stimuli, corresponding to
rotational and translational displacements. If the reconstructed stimulus is to
be represented by a Volterra series and correlations between spikes are to be
taken into account, first order expansions are insufficient and we have to go
to second order, at least. In this case higher order correlation functions have
to be manipulated, whose size may become prohibitively large. We therefore
develop a Gaussian-like representation for fourth order correlation functions,
which works exceedingly well in the case of the fly. The reconstructions using
this Gaussian-like representation are very similar to the reconstructions using
the experimental correlation functions. The overall contribution to rotational
stimulus reconstruction of the second order kernels - measured by a chi-squared
averaged over the whole experiment - is only about 8% of the first order
contribution. Yet if we introduce an instant-dependent chi-square to measure
the contribution of second order kernels at special events, we observe an up to
100% improvement. As may be expected, for translational stimuli the
reconstructions are rather poor. The Gaussian-like representation could be a
valuable aid in population coding with large number of neurons
On the quantumness of correlations in nuclear magnetic resonance
Nuclear Magnetic Resonance (NMR) was successfully employed to test several
protocols and ideas in Quantum Information Science. In most of these
implementations the existence of entanglement was ruled out. This fact
introduced concerns and questions about the quantum nature of such bench tests.
In this article we address some issues related to the non-classical aspects of
NMR systems. We discuss some experiments where the quantum aspects of this
system are supported by quantum correlations of separable states. Such
quantumness, beyond the entanglement-separability paradigm, is revealed via a
departure between the quantum and the classical versions of information theory.
In this scenario, the concept of quantum discord seems to play an important
role. We also present an experimental implementation of an analogous of the
single-photon Mach-Zehnder interferometer employing two nuclear spins to encode
the interferometric paths. This experiment illustrate how non-classical
correlations of separable states may be used to simulate quantum dynamics. The
results obtained are completely equivalent to the optical scenario, where
entanglement (between two field modes) may be present
Selection Effects, Biases, and Constraints in the Calan/Tololo Supernova Survey
We use Monte Carlo simulations of the Calan/Tololo photographic supernova
survey to show that a simple model of the survey's selection effects accounts
for the observed distributions of recession velocity, apparent magnitude,
angular offset, and projected radial distance between the supernova and the
host galaxy nucleus for this sample of Type Ia supernovae (SNe Ia). The model
includes biases due to the flux-limited nature of the survey, the different
light curve morphologies displayed by different SNe Ia, and the difficulty of
finding events projected near the central regions of the host galaxies. From
these simulations we estimate the bias in the zero-point and slope of the
absolute magnitude-decline rate relation used in SNe Ia distance measurements.
For an assumed intrinsic scatter of 0.15 mag about this relation, these
selection effects decrease the zero-point by 0.04 mag. The slope of the
relation is not significantly biased. We conclude that despite selection
effects in the survey, the shape and zero-point of the relation determined from
the Calan/Tololo sample are quite reliable. We estimate the degree of
incompleteness of the survey as a function of decline rate and estimate a
corrected luminosity function for SNe Ia in which the frequency of SNe appears
to increase with decline rate (the fainter SNe are more common). Finally, we
compute the integrated detection efficiency of the survey in order to infer the
rate of SNe Ia from the 31 events found. For a value of Ho=65 km/sec/Mpc we
obtain a SN Ia rate of 0.21(+0.30)(-0.13) SNu. This is in good agreement with
the value 0.16+/-0.05 SNu recently determined by Capellaro et al. (1997).Comment: 36 pages, 19 figures as extra files, to appear in the A
A 'p-n' diode with hole and electron-doped lanthanum manganite
The hole-doped manganite La0.7Ca0.3MnO3 and the electron-doped manganite
La0.7Ce0.3MnO3 undergo an insulator to metal transition at around 250 K, above
which both behave as a polaronic semiconductor. We have successfully fabricated
an epitaxial trilayer (La0.7Ca0.3MnO3/SrTiO3/La0.7Ce0.3MnO3), where SrTiO3 is
an insulator. At room temperature, i.e. in the semiconducting regime, it
exhibits asymmetric current-voltage (I-V) characteristics akin to a p-n diode.
The observed asymmetry in the I-V characteristics disappears at low
temperatures where both the manganite layers are metallic. To the best of our
knowledge, this is the first report of such a p-n diode, using the polaronic
semiconducting regime of doped manganites.Comment: PostScript text and 2 figures, to be published in Appl. Phys. Lett
Attachment, Physiological and Familial Vulnerability in Childhood Obesity: an Interactive Multisystem Approach
The aims of the present study were to test the association between insecure attachment and basal cortisol and catecholamines levels in a sample of obese children. The role of familial vulnerability and gender was also investigated.
Methods: Cortisol and catecholamines levels of 8- to 13-year olds obese children were measured. Self-report questionnaires were used to assess attachment pattern and current anxiety and depression, and parent-report questionnaires were used to assess attachment, current anxiety and depression and familial vulnerability. Linear regression analyses were performed for individuals that scored low versus high on parental internalizing problems, and for boys and girls, separately.
Results: In the group with high parental internalizing problems, insecure attachment was significantly associated with reduced basal levels of cortisol, in boys (p=0.007, b= -0.861, R2= 73.0%). In the group with low parental internalizing problems, the association between insecure attachment and cortisol was not significant in either boys or girls, and it was negative in boys (p=0.075, b= -0.606, R2= 36.7%) and positive in girls (p=0.677, b= 0.176, R2= 3.1%) .
Conclusions: Apparently, physiological risk factors for psicopathology in obesity are more evident in individuals with a high familial vulnerability. In addition, patterns of physiological risk for psicopathology in obesity are different in boys and girls. Therefore, it is important to take into account familial vulnerability and gender when investigating physiological risk factors for psycopathology in obesity. Insecure attachment in childhood may be a risk factor for obesity. Interventions to increase children's attachment security should examine the effects on children's weight
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