EFICÁCIA DE NÚCLEO HOMEOPÁTICO NA PREVENÇÃO DA INFESTAÇÃO POR Dermatobia hominis E Haematobia irritans EM BOVINOS

O presente trabalho foi desenvolvido na UFPR - Campus Palotina - Paraná e em uma propriedade rural do município de Mundo Novo - Mato Grosso do Sul, durante o período de maio de 2002 a abril de 2003. O experimento foi delineado com os objetivos de avaliar: a) a eficácia do núcleo homeopático (nosódicos CH12, sacarose e Bixa orelhana) na prevenção da infestação natural por larvas de D. hominis e H. irritans em bovinos de corte e b) a dinâmica populacional de D. homins e H. irritans ao longo do ano. Para sua realização foram utilizados 24 vacas, de aproximadamente 15 meses de idade, distribuídas em dois grupos de 12 animais, com pesos médios semelhantes. Os animais do grupo A foram tratados com núcleo homeopático adicionado à suplementação mineral na proporção de 400 g de núcleo adicionado em 25 Kg da mesma. Os animais do grupo B receberam suplementação mineral (sem adição de núcleo homeopático). Foram contadas um total de 451 larvas de D. hominis. A análise de variância demonstrou diferença estatística significativa (

Growth inhibitory effects of 3′-nitro-3-phenylamino nor-beta-lapachone against HL-60: A redox-dependent mechanism

AbstractIn this study, the cytotoxicity, genotoxicity and early ROS generation of 2,2-dimethyl-(3H)-3-(N-3′-nitrophenylamino)naphtho[1,2-b]furan-4,5-dione (QPhNO2) were investigated and compared with those of its precursor, nor-beta-lapachone (nor-beta), with the main goal of proposing a mechanism of antitumor action. The results were correlated with those obtained from electrochemical experiments held in protic (acetate buffer pH 4.5) and aprotic (DMF/TBABF4) media in the presence and absence of oxygen and with those from dsDNA biosensors and ssDNA in solution, which provided evidence of a positive interaction with DNA in the case of QPhNO2. QPhNO2 caused DNA fragmentation and mitochondrial depolarization and induced apoptosis/necrosis in HL-60 cells. Pre-treatment with N-acetyl-l-cysteine partially abolished the observed effects related to the QPhNO2 treatment, including those involving apoptosis induction, indicating a partially redox-dependent mechanism. These findings point to the potential use of the combination of pharmacology and electrochemistry in medicinal chemistry

All-sky search for long-duration gravitational wave transients with initial LIGO

We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society