Cholestasis of pregnancy: a prospective analysis from a South Andaman teaching hospital

Background: Intrahepatic cholestasis of pregnancy (IHCP) is one of the commonest pregnancy related liver disorder. Although the maternal course is usually benign, there is an increased risk of spontaneous preterm delivery, fetal compromise, meconium stained amniotic fluid and even intrauterine fetal demise. The objective of this study was to study the incidence of IHCP and its impact on maternal and perinatal outcome.Methods: A prospective study carried out in 68 number of IHCP cases. Diagnosis was done on the basis of clinical and laboratory parameters. All the cases were followed up to the puerperium to find out maternal and perinatal outcome.Results: The incidence of cholestasis of pregnancy was 2.73%. Most (88%) of the cases were presented with generalized pruritus, relived with ursodeoxycholic acid and complete recovery was observed after delivery. The rate of instrumental delivery was 8.82% and caesarean section rate was 30.88%. Most common indication of caesarean section was fetal distress and non-progress of labour. There was one stillbirth at 35 weeks however none of the mother had complication during labour or puerperal period.Conclusions: Increased level of liver enzymes in patients of IHCP associated with poor perinatal outcome. Therefore, careful monitoring during antenatal period and termination of pregnancy at term will result in favourable outcome of both mother and baby

Enhanced Synthetic Access to Tris-CF₃-Substituted Corroles

Separate focus on the oligomerization and oxidative cyclization steps required for the synthesis of 5,10,15-tris(trifluoromethyl)corrole revealed [bis(trifluoroacetoxy)iodo]benzene (PIFA) as a superior alternative oxidant. Under optimized conditions, the pure free-base corrole was obtained with a 6-fold increase in chemical yield and an 11-fold rise in isolated material per synthesis. The corresponding gallium(III) and manganese(III) complexes were isolated by adding the appropriate metal salt prior to corrole purification

Growth attributes of malt barley (Hordeum vulgare) as influenced by fertility levels and liquid biofertilizers

The experiments were conducted during winter (rabi) seasons of 2020–21 and 2021–22 at Rajasthan College of Agriculture, Maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan to study the effect of fertility levels and biofertilizers on malt barley (Hordeum vulgare L.). Factorial randomized block design (F-RBD) was used comprising 15 treatment combinations involved 3 fertility levels, viz. 50 N + 25 P2O5 + 15 K2O kg/ha; 60 N + 30 P2O5 + 20 K2O kg/ha; and 70 N + 40 P2O5 + 25 K2O kg/ha; alongside 5 liquid biofertilizers, viz. control; Azotobacter; Phosphorous solubilizing bacteria; Potassium mobilizing bacteria; and Azotobacter + Phosphorous solubilizing bacteria + Potassium mobilizing bacteria. The findings indicate that applying a fertilizer combination of 70 N + 40 P2O5 + 25 K2O kg/ha to malt barley crop significantly enhanced plant height at harvest (118.74 cm), dry- matter accumulation/m row at harvest (356.88 g), leaf area index (LAI) at 50 DAS (days after sowing) (1.69) and 75 DAS (2.87), number of total tillers (89.97) and growth efficiency values, substantially greater than other fertility levels. The findings demonstrated that inoculating seeds with a combination of liquid biofertilizers containing Azotobacter + Phosphorous solubilizing bacteria + Potassium mobilizing bacteria significantly improved growth parameters, viz. plant height at harvest (117.55 cm), dry-matter accumulation/m row at harvest (371.25 g), LAI at 50 DAS (1.68) and 75 DAS (2.96), number of total tillers (90.08) and growth efficiency values

Contextual Ambiguity Framework for Enhanced Sentiment Analysis

Negation is a universal linguistic phenomenon that affects the performance of Natural Language Processing (NLP) applications, especially opinion mining data. Many words exists in sentences that have multiple interpretations or sentiments depending on how they are placed with respect to the negation word in the sentence. A cutting-edge framework is designed to tackle the nuanced challenge of detecting contextual ambiguity through negation in sentiment analysis. The approach uniquely combines advanced natural language processing techniques with deep linguistic insights, enabling the accurate interpretation of sentiment in complex sentences where negation plays a key role. The framework identifies negation cues and their scope, then assesses their impact on sentiment, considering contextual dependencies and word semantics. The model's innovation lies in context-sensitive algorithms that adeptly handle different sentence structures and idiomatic expressions, a notable advancement over traditional sentiment analysis tools. Particularly effective in interpreting sarcastic or ironic statements, the framework significantly outperforms existing models in accuracy, especially in negation-heavy contexts. This advancement enhances sentiment analysis applications like social media monitoring and customer feedback analysis, offering a more nuanced understanding of public opinion

Facile Generation of A₂B Corrole Radical Using Fe(III) Salts and Its Spectroscopic Properties

A carboxyphenyl-substituted corrole, 5,15-dimesityl-10-(4′-carboxyphenyl)­corrole (<b>1</b>), has been synthesized and characterized by UV–vis, fluorescence, ¹H NMR spectroscopy, and electrospray ionization (ESI)-mass spectrometry (MS) techniques. An air-stable corrole radical (<b>1</b>^•) was obtained with the addition of the Fe­(III) salt to <b>1</b> in dimethyl sulfoxide (DMSO) and characterized by UV–vis, fluorescence, electron paramagnetic resonance (EPR), ESI-MS techniques, and density functional theory studies. The neutral corrole radical (<b>1</b>^•) exhibited a sharp EPR signal at <i>g</i> = 2.006 in DMSO. The reduced bipyrrolic (N–C–C–N) dihedral angle (χ) of <b>1</b> from 19.11 to 7.07° leads to the release of angle strain, which is the driving force for the generation of <b>1</b>^•. Notably, <i>trans</i>-dimesityl groups prevent the dimerization or aggregation of the corrole radical. Further, <b>1</b>^• was converted to <b>1</b> by excess addition of Fe­(II) salts in DMSO at 298 K

Effect of Phosphorus and Sulphur Levels on Growth, Nodulation and Yield of Soybean [Glycine max (L.) Merrill] in South-Eastern Part of Rajasthan

An experiment was conducted at Instructional Farm, College of Agriculture, Ummedganj, Kota during kharif, 2021. The twelve treatment combinations comprised of four levels of phosphorus viz., 0, 20, 40 and 60 kg ha-1 allocated in main plots and three levels of sulphur viz., 15, 30 and 45 kg ha-1 in sub plots. Results showed that application of 60 kg P2O5 ha-1 had significant effect on plant height at 60 DAS and at harvest, number of total root nodules plant-1, effective root nodules plant-1 and dry weight of root nodules at 45 DAS, chlorophyll content at 45 DAS and leaf area index at 50 DAS of soybean over application of 20 kg P2O5 ha-1 and control but it was found at par with 40 kg P2O5 ha-1. The maximum seed yield (1942 kg ha-1) and straw (3305 kg ha-1) yield of soybean were recorded under application of 60 kg P2O5 ha-1 over application of 20 kg P2O5 ha-1 and control but it was found at par with 40 kg P2O5 ha-1. Significantly higher plant height at 60 DAS and at harvest, number of total root nodules plant-1, effective root nodules plant-1 and their dry weight at 45 DAS, chlorophyll content at 45 DAS, leaf area index at 50 DAS, seed yield (1870 kg ha-1) and straw yield (3179 kg ha-1) of soybean were recorded under application of 45 kg sulphur ha-1 which was found at par with 30 kg sulphur ha-1 &nbsp;and both these sulphur levels gave significant increase over application of 15 kg sulphur ha-1

Facile and Reversible Electrogeneration of Porphyrin Trianions and Tetraanions in Nonaqueous Media

The first examples for the facile, reversible, and stepwise electrogeneration of triply ring-reduced porphyrin macrocycles are presented. The investigated compounds are represented as MTPP­(NO₂)­(PE)₆, MTTP­(PE)₈, NiTPP­(NO₂)­(Ph)₄, and MTPP­(CN)₄, where TTP and TPP are the dianions of tetratolylporphyrin and tetraphenylporphyrin, respectively, NO₂, phenylethynyl (PE), and CN are substituents at the β-pyrrole positions of the macrocycle, and M = Cu^II, Ni^II, Zn^II, Co^II, or 2H. Each porphyrin undergoes three or four reductions within the negative potential limit of the electrochemical solvent. The UV–visible spectra of the first three reduction products were characterized by means of thin-layer UV–vis spectroelectrochemistry, and the generation of multianionic porphyrins is interpreted in terms of extensive stabilization of the LUMOs due to the electron-withdrawing and/or extended π-conjugation of the β-substituents