Exposure to novel coronavirus in patients on renal replacement therapy during the exponential phase of COVID-19 pandemic: survey of the Italian Society of Nephrology

Background: Between February and April 2020, Italy experienced an overwhelming growth of the COVID-19 pandemic. Little is known, at the country level, where and how patients on renal replacement therapy (RRT) have been mostly affected. Methods: Survey of the network of Nephrology centers using a simplified 17 items electronic questionnaire designed by Italian Society of Nephrology COVID-19 Research Group. We used spatial epidemiology and geographical information systems to map SARS-CoV-2 spread among RRT patients in Italy. Results: On April 9th 2020, all nephrology centers (n = 454) listed in the DialMap database were invited to complete the electronic questionnaire. Within 11 days on average, 365 centers responded (80.4% response rate; 2.3% margin of error) totaling 60,441 RRT patients. The surveyed RRT population included 30,821 hemodialysis (HD), 4139 peritoneal dialysis (PD), and 25,481 transplanted (Tx) patients respectively. The proportion of SARS-CoV-2 positive RRT patients in Italy was 2.26% (95% CI 2.14\u20132.39) with significant differences according to treatment modality (p < 0.001). The proportion of patients positive for SARS-CoV-2 was significantly higher in HD (3.55% [95% CI 3.34\u20133.76]) than PD (1.38% [95% CI 1.04\u20131.78] and Tx (0.86% [95% CI 0.75\u20130.98]) (p < 0.001), with substantial heterogeneity across regions and along the latitude gradient (p < 0.001). In RRT patients the highest rate was in the north-west (4.39% [95% CI 4.11\u20134.68], followed by the north-east (IR 2.06% [1.79\u20132.36]), the center (0.91% [0.75\u20131.09]), the main islands (0.67% [0.47\u20130.93]), and the south (0.59% [0.45\u20130.75]. During the COVID-19 pandemic, among SARS-Cov-2 positive RRT patients the fatality rate was 32.8%, as compared to 13.3% observed in the Italian population as of April 23rd. Conclusions: A substantial proportion of the 60,441 surveyed RRT patients in Italy were SARS-Cov-2 positive and subsequently died during the exponential phase of COVID-19 pandemic. Infection risk and rates seems to differ substantially across regions, along geographical latitude, and by treatment modality

Self-medication for migraine: a Nationwide cross-sectional study in Italy

Headache disorders are considered the second leading cause of years lived with disability worldwide, and 90% of people have a headache episode at least once a year, thus representing a relevant public health priority. As the pharmacist is often the first and only point of reference for people complaining of headache, we carried out a survey in a nationwide sample of Italian pharmacies, in order to describe the distribution of migraine or non-migraine type headaches and medicines overuse among people entering pharmacies seeking for self-medication; and to evaluate the association, in particular of migraine, with socio-demographic and clinical characteristics, and with the pathway of care followed by the patients. A 14-item questionnaire, including socio-demographic and clinical factors, was administered by trained pharmacists to subjects who entered a pharmacy requesting self-medication for a headache attack. The ID Migraine™ Screener was used to classify headache sufferers in four classes. From June 2016 to January 2017, 4424 people have been interviewed. The prevalence of definite migraines was 40%, significantly higher among women and less educated people. About half of all headache sufferers and a third of migraineurs do not consider their condition as a disease and are not cared by any doctor. Among people seeking self-medication in pharmacies for acute headache attacks, the rate of definite or probable migraine is high, and a large percentage of them is not correctly diagnosed and treated. The pharmacy can be a valuable observatory for the study of headaches, and the first important step to improve the quality of care delivered to these patients

11th European Headache Federation Congress jointly with 31st Congress of the Italian Society for the Study of Headaches : Rome, Italy. 01-03 December 2017

. Aims of the study were explore the relationship between peripheral chromatic and central visual dysfunction evaluating also the presence of functional receptor impairment in patients with migraine, with and without aura examined interictally

A Unified Architecture for Dynamic Role Allocation and Collaborative Task Planning in Mixed Human-Robot Teams

The growing deployment of human-robot collaborative processes in several industrial applications, such as handling, welding, and assembly, unfolds the pursuit of systems which are able to manage large heterogeneous teams and, at the same time, monitor the execution of complex tasks. In this paper, we present a novel architecture for dynamic role allocation and collaborative task planning in a mixed human-robot team of arbitrary size. The architecture capitalizes on a centralized reactive and modular task-agnostic planning method based on Behavior Trees (BTs), in charge of actions scheduling, while the allocation problem is formulated through a Mixed-Integer Linear Program (MILP), that assigns dynamically individual roles or collaborations to the agents of the team. Different metrics used as MILP cost allow the architecture to favor various aspects of the collaboration (e.g. makespan, ergonomics, human preferences). Human preference are identified through a negotiation phase, in which, an human agent can accept/refuse to execute the assigned task.In addition, bilateral communication between humans and the system is achieved through an Augmented Reality (AR) custom user interface that provides intuitive functionalities to assist and coordinate workers in different action phases. The computational complexity of the proposed methodology outperforms literature approaches in industrial sized jobs and teams (problems up to 50 actions and 20 agents in the team with collaborations are solved within 1 s). The different allocated roles, as the cost functions change, highlights the flexibility of the architecture to several production requirements. Finally, the subjective evaluation demonstrating the high usability level and the suitability for the targeted scenario.Comment: 18 pages, 20 figures, 2nd round review at Transaction on Robotic

Detrital Thermochronometry Reveals That the Topography Along the Antarctic Peninsula is Not a Pleistocene Landscape

Using offshore detrital apatite (U‐Th)/He thermochronometry and 3D thermo‐kinematic modeling of the catchment topography, we constrain the timing of major topographic change at Bourgeois Fjord, Antarctic Peninsula (AP). While many mid‐latitude glacial landscapes developed primarily in response to global cooling over the last ~2.6 Ma, we find that kilometer‐scale landscape evolution at Bourgeois Fjord began ~30–12 Ma ago and <2 km of valley incision has occurred since ~16 Ma. This early onset of major topographic change occurred following the initiation of alpine glaciation at this location and prior to the development of a regional polythermal ice sheet inferred from sedimentary evidence offshore of the AP. We hypothesize that topographic change relates to (i) feedbacks between an evolving topography and glacial erosion processes, (ii) effects of glacial‐interglacial variability, and (iii) the prevalence of subglacial meltwater. The timing and inferred spatial patterns of long‐term exhumation at Bourgeois Fjord are consistent with a hypothesis that glacial erosion processes were suppressed at the AP during global Plio‐Pleistocene cooling, rather than enhanced. Our study examines the long‐term consequences of glacial processes on catchment‐wide erosion as the local climate cooled. Our findings support the hypothesis that landscapes at different latitudes had different responses to global cooling. Our results also suggest that erosion is enhanced along the plateau flanks of Bourgeois Fjord today, which may be due to periglacial processes or mantling via subglacial till. If regional warming persists and meltwater becomes more pronounced, we predict that enhanced erosion along the plateau flank will accelerate topographic change

Suffolk Journal, Vol. 46, No. 16, 1/30/1989

https://dc.suffolk.edu/journal/2173/thumbnail.jp