Synthesis, crystal structure, luminescent, and gas adsorption properties of a new Zn(II) compound with two different dinuclear [Zn₂(COO)₃] subunits

<p>Presented here is a new Zn(II) compound, namely [Zn₄(btec)₂(DMA)₃]_n (1 represents this compound, H₄btec = 1,2,4,5-benzenetetracarboxylic acid, DMA = N,N′-dimethylacetamide). This compound crystallizes in orthorhombic <i>P</i>bca space group with <i>a</i> = 19.053(2) Å, <i>b</i> = 18.8010(6) Å, <i>c</i> = 22.9434(8) Å, α = β = γ = 90°, and <i>Z</i> = 8. Single crystal X-ray diffraction analysis reveals that compound 1 features a three-dimensional (3D) framework based on two different dinuclear [Zn₂(COO)₃] subunits. In addition, the solid-state luminescent property of 1 and the gas sorption properties of the desolvated 1a were also investigated.</p

Additional file 1 of Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19

Additional file 1: Supplementary Table 1. The detail information of 22 Candidate gene SNPs. Supplementary Table 2. Genotype and allele distributions of candidate SNPs between the two groups. Supplementary Table 3. Multivariable logistic regression analysis adjusted for age, gender and comorbidities. Supplementary Table 4. Multivariable logistic regression analysis of 20 candidate variants in different gender groups. Supplementary Table 5. Analysis between MX1 rs17000900, FOXP4 rs1886814 and rs2894439 genotypes and neutralizing antibody titers. Supplementary Table 6. The linkage disequilibrium coefficients among two SNPs of MX1. Supplementary Table 7. The linkage disequilibrium coefficients among two SNPs of FOXP4. Supplementary Table 8. The linkage disequilibrium coefficients among four SNPs of OAS gene cluster. Supplementary Table 9. Association between haplotypes of the OAS gene cluster and the severity of COVID-19. Supplementary Table 10. Calculation of minimum sample size in case and control group

Enhanced immunity against SARS-CoV-2 in returning Chinese individuals

Global COVID-19 vaccination programs effectively contained the fast spread of SARS-CoV-2. Characterizing the immunity status of returned populations will favor understanding the achievement of herd immunity and long-term management of COVID-19 in China. Individuals were recruited from 7 quarantine stations in Guangzhou, China. Blood and throat swab specimens were collected from participants, and their immunity status was determined through competitive ELISA, microneutralization assay and enzyme-linked FluoroSpot assay. A total of 272 subjects were involved in the questionnaire survey, of whom 235 (86.4%) were returning Chinese individuals and 37 (13.6%) were foreigners. Blood and throat swab specimens were collected from 108 returning Chinese individuals. Neutralizing antibodies against SARS-CoV-2 were detected in ~90% of returning Chinese individuals, either in the primary or the homologous and heterologous booster vaccination group. The serum NAb titers were significantly decreased against SARS-CoV-2 Omicron BA.5, BF.7, BQ.1 and XBB.1 compared with the prototype virus. However, memory T-cell responses, including specific IFN-γ and IL-2 responses, were not different in either group. Smoking, alcohol consumption, SARS-CoV-2 infection, COVID-19 vaccination, and the time interval between last vaccination and sampling were independent influencing factors for NAb titers against prototype SARS-CoV-2 and variants of concern. The vaccine dose was the unique common influencing factor for Omicron subvariants. Enhanced immunity against SARS-CoV-2 was established in returning Chinese individuals who were exposed to reinfection and vaccination. Domestic residents will benefit from booster homologous or heterologous COVID-19 vaccination after reopening of China, which is also useful against breakthrough infection.</p