684 research outputs found
7-Chloro-5-(2-ethoxyphenyl)-1-methyl-3-propyl-2,6-dihydro-1H-pyrazolo[4,3-d]pyrimidine
In the title compound, C17H21ClN4O, the benzene ring is oriented at dihedral angles of 1.59 (3) and 1.27 (3)° with respect to the pyrimidine and pyrazole rings, while the dihedral angle between the pyrimidine and pyrazole rings is 0.83 (3)°. An intramolecular N—H⋯O hydrogen bond results in the formation of a planar (r.m.s. deviation 0.004 Å) six-membered ring
Bis(μ-carboxylatoethylphosphonato)bis[aqua(2,2′-bipyridine)manganese(II)]
The title compound, [Mn2(HO3PCH2CH2COO)2(C8H8N2)2(H2O)2], was obtained by hydrothermal synthesis. The manganese(II) ions are six-coordinate and are linked by two 2-carboxyethylphosphonate ligands, forming a centrosymmetric dimer. The Mn ions adopts a distorted octahedral coordination geometry. The dimers are further linked by O—H⋯O hydrogen bonds and π–π stacking interactions [centroid–centroid distance 4.2754 (4) Å]
Two Photon Decays of from Lattice QCD
We present an exploratory lattice study for the two-photon decay of
using twisted mass lattice QCD gauge configurations generated by the
European Twisted Mass Collaboration. Two different lattice spacings of
fm and fm are used in the study, both of which are of
physical size of 2. The decay widths are found to be KeV for the
coarser lattice and KeV for the finer lattice respectively where the
errors are purely statistical. A naive extrapolation towards the continuum
limit yields KeV which is smaller than the previous
quenched result and most of the current experimental results. Possible reasons
are discussed.Comment: 13 pages, 7 figures; matches the published versio
Potent anti-tumor activity of telomerase-dependent and HSV-TK armed oncolytic adenovirus for non-small cell lung cancer in vitro and in vivo
<p>Abstract</p> <p>Background</p> <p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer related mortality, any improvements in therapeutic strategies are urgently required. In this study we generated a novel 'suicide gene' armed oncolytic adenoviral vector and investigated its antitumor effect both in vitro and in vivo.</p> <p>Methods</p> <p>Since the up-regulated expression of human telomerase reverse transcriptase (hTERT) is a hallmark of alltypes of NSCLC, we chose hTERT promoter to transcriptionally control E1A gene expression to obtain adenoviral replication in NSCLC. In order to further enhance anti-tumor effect of this oncolytic adenoviral vector, we inserted a 'suicide gene' i.e. Herpes Simplex Virus Thymidine Kinase (HSV-TK) into oncolytic adenoviral vector to engineer a novel armed oncolytic adenoviral vector 'Ad.hTERT-E1A-TK'.</p> <p>Results</p> <p>Ad.hTERT-E1A-TK efficiently killed different types of tumor cells including two types of NSCLC cells <it>in vitro</it>, causing no damage to normal primary fibroblasts. Furthermore, Ad.hTERT-E1A-TK infection combined with administration of prodrug gancyclovir (GCV) resulted in more potent cytotoxicity on NSCLC cells, and synergistically suppressed human NSCLC tumor growth in nude mice.</p> <p>Conclusion</p> <p>The results from this study showed that Ad.hTERT-E1A-TK/GCV could be a potent but safe anti-tumor strategy for NSCLC biotherapy.</p
The elicitor VP2 from Verticillium dahliae triggers defence response in cotton
Summary: Verticillium dahliae is a widespread and destructive soilborne vascular pathogenic fungus that causes serious diseases in dicot plants. Here, comparative transcriptome analysis showed that the number of genes upregulated in defoliating pathotype V991 was significantly higher than in the non‐defoliating pathotype 1cd3‐2 during the early response of cotton. Combined with analysis of the secretome during the V991–cotton interaction, an elicitor VP2 was identified, which was highly upregulated at the early stage of V991 invasion, but was barely expressed during the 1cd3‐2‐cotton interaction. Full‐length VP2 could induce cell death in several plant species, and which was dependent on NbBAK1 but not on NbSOBIR1 in N. benthamiana. Knock‐out of VP2 attenuated the pathogenicity of V991. Furthermore, overexpression of VP2 in cotton enhanced resistance to V. dahliae without causing abnormal plant growth and development. Several genes involved in JA, SA and lignin synthesis were significantly upregulated in VP2‐overexpressing cotton. The contents of JA, SA, and lignin were also significantly higher than in the wild‐type control. In summary, the identified elicitor VP2, recognized by the receptor in the plant membrane, triggers the cotton immune response and enhances disease resistance
A Necessary And Sufficient Condition of Distillability with unite fidelity from Finite Copies of a Mixed State: The Most Efficient Purification Protocol
It is well known that any entangled mixed state in systems can
be purified via infinite copies of the mixed state. But can one distill a pure
maximally entangled state from finite copies of a mixed state in any bipartite
system by local operation and classical communication? This is more meaningful
in practical application. We give a necessary and sufficient condition of this
distillability. This condition can be expressed as: there exists
distillable-subspaces. According to this condition, one can judge whether a
mixed state is distillable or not easily. We also analyze some properties of
distillable-subspaces, and discuss the most efficient purification protocols.
Finally, we discuss the distillable enanglement of two-quibt system for the
case of finite copies.Comment: a revised versio
- …