Software for doing computations in graded Lie algebras

We introduce the Macaulay2 package GradedLieAlgebras for doing computations in graded Lie algebras presented by generators and relations.Comment: 5 page

Overall survival (OS), time to progression (TTP), and progression.

<p>Overall survival (OS), time to progression (TTP), and progression.</p

Relative risk of Grade III/IV adverse events in patients treates with TACE plus sorafenib versus TACE.

<p>Relative risk of Grade III/IV adverse events in patients treates with TACE plus sorafenib versus TACE.</p

Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis

<div><p>Background</p><p>Gallstones (GS) is the major manifestation of gallbladder disease, and is the most common risk factor for gallbladder cancer (GBC). Previous studies investigating the association between <i>ApoB-100</i> gene polymorphisms and the risks of GS and GBC have yielded conflicting results. Therefore, we performed a meta-analysis to clarify the effects of <i>ApoB-100</i> gene polymorphisms on the risks of GS and GBC.</p><p>Methods</p><p>A computerized literature search was conducted to identify the relevant studies from PubMed and Embase. Fixed or random effects model was selected based on heterogeneity test. Publication bias was estimated using Begg’s funnel plots and Egger’s regression test.</p><p>Results</p><p>A total of 10, 3, and 3 studies were included in the analyses of the association between <i>ApoB-100</i> XbaI, EcoRI, or insertion/deletion (ID) polymorphisms and the GS risks, respectively, while 3 studies were included in the analysis for the association between XbaI polymorphism and GBC risk. The combined results showed a significant association in Chinese (X+ <i>vs.</i> X−, OR = 2.37, 95%CI 1.52–3.70; X+X+/X+X- <i>vs.</i> X+X+, OR = 2.47, 95%CI 1.55–3.92), but not in Indians or Caucasians. Null association was observed between EcoRI or ID polymorphisms and GS risks. With regard to the association between XbaI polymorphism and GBC risk, a significant association was detected when GBC patients were compared with healthy persons and when GBC patients were compared with GS patients. A significant association was still detected when GBC patients (with GS) were compared with the GS patients (X+X+ <i>vs.</i> X-X−, OR = 0.33, 95%CI 0.12–0.90).</p><p>Conclusion</p><p>The results of this meta-analysis suggest that the <i>ApoB-100</i> X+ allele might be associated with increased risk of GS in Chinese but not in other populations, while the <i>ApoB-100</i> X+X+ genotype might be associated with reduced risk of GBC. Further studies with larger sample sizes are needed to confirm these results.</p></div

Characteristics of individual studies for association between <i>ApoB-100</i> gene polymorphisms and risks of gall stones (GS).

a<p>the mean age of case and controls;</p>b<p>the gender was shown as the percentage of the males;</p>c<p>HB and PB referred to hospital-based controls and population-based controls, respectively;</p>d<p>11,12,22 represented X−X−, X−X+, X+X+ for XbaI polymorphism, GG, AG, AA for EcoRI polymorphism, II, ID, DD for insertion/deletion polymorphism, respectively;</p>e<p><i>p</i> for Hardy–Weinberg equilibrium test in controls;</p><p>“Na” means not available.</p

Eligibility of studies for inclusion in the meta-analysis.

<p>Eligibility of studies for inclusion in the meta-analysis.</p

Baseline Characteristics of the included studies.

<p>TACE, transartialchemoembolization; LC, liver cirrhosis; OS, overall survival; TTP, time to progression; DCR, disease control rate; NR, not report; HBV, hepatitis B virus; HCV, hepatitis C virus; SOR, sorafenib.</p

Meta-analysis of the <i>ApoB-100</i> XbaI polymorphism and the risks of GBC (genotype X+X+/X+X− <i>vs.</i> X−X−).

<p>Meta-analysis of the <i>ApoB-100</i> XbaI polymorphism and the risks of GBC (genotype X+X+/X+X− <i>vs.</i> X−X−).</p

Summary of ORs for various contrasts on the association between <i>ApoB-100</i> gene polymorphisms and risks of gall bladder cancer (GBC).

a<p>Model, statistical model; FEM, fixed effect model; REM, random effect model.</p>b<p><i>p</i> value for heterogeneity based on Q test;</p><p>Abbreviations: GS, gallstone; GBC, gallbladder cancer.</p