103 research outputs found
Structural characterization and regiochemical differentiation of α-cyanoethylindole isomers in the gas phase
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
DielsâAlder Chemistry of Siloles and Their Transformation into Cyclohex-2-ene-1,4- cis
Neue potentielle DNA-Interkalatoren der Carbazol-Reihe aus Indol-2,3-chinodimethanen: Synthese, Kristallstruktur und Molecular Modeling mit einer Watson-Crick Minihelix
Diindolylmethanes, III: IR- and NMR-spectroscopic investigations of arylsubstituted 2,2?-diindolylmethan-3,3?-bis[2-(acetylamino)propionicacid methylesters]
Freie Gewebetransplantation zur Defektdeckung am Unterschenkel bei EingefĂ€Ă-Versorgung - Management und Outcome
Facile Synthesis of 3(α,ÎČâDiaryl Vinyl)Indoles Under Conventional and SolventâFree Microwave Irradiation
Evaluation of the ITS planning process. Final report.
Virginia Department of Transportation, RichmondFederal Highway Administration, Washington, D.C.Mode of access: Internet.Author corporate affiliation: Virginia Transportation Research Council, CharlottesvilleSubject code: FSSubject code: WW
Reaktionen von elektronenreichen Heterocyclen mit Orthocarbonsïżœure-Derivaten, VII. Regioselective milde Acylierung von 2-Methylindol mit Di- und Trialkoxycarbenium-tetrafluoroboraten ? ein einfacher Zugang zu 3-Acyl-2-methylindolen und 3-Methoxycarbonyl-2-methylindol
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