Hyperglycaemic non-ketotic coma following surgically treated acromegaly in a non-diabetic

Extremely severe, hyperglybemic, hyperosmolar, nonketotic coma occurred in a 47-year-old, apparently nondiabetic, acromegalic woman shortly after having her pituitary adenoma removed. She was totally unconscious, shocked, anuric, grossly dehydrated and in status pilepticus but she recovered, and has remained non-diabetic, with diminished adrenal response and growth hormone levels returning to normal. Her plasma insulin response to glucose is excellent.The factors that precipitated this syndrome in this patient are obscure to us