APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies.

OBJECTIVE To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. METHODS To identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative" and "optical coherence tomography" from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial APOSTEL recommendations via online surveys following the principle of a modified Delphi method. The results were evaluated and discussed by a panel of experts and changes to the initial recommendations were proposed. A final survey was recirculated among the corresponding authors to obtain a majority vote on the proposed changes. RESULTS A total of 116 authors participated in the surveys, resulting in 15 suggestions, of which 12 were finally accepted and incorporated into an updated 9-point checklist. We harmonized the nomenclature of the outer retinal layers, added the exact area of measurement to the description of volume scans, and suggested reporting device-specific features. We advised to address potential bias in manual segmentation or manual correction of segmentation errors. References to specific reporting guidelines and room light conditions were removed. The participants' consensus with the recommendations increased from 80% for the previous APOSTEL version to greater than 90%. CONCLUSIONS The modified Delphi method resulted in an expert-led guideline (evidence Class III; Grading of Recommendations, Assessment, Development and Evaluations [GRADE] criteria) concerning study protocol, acquisition device, acquisition settings, scanning protocol, funduscopic imaging, postacquisition data selection, postacquisition analysis, nomenclature and abbreviations, and statistical approach. It will be essential to update these recommendations to new research and practices regularly

25-hydroxyvitamin D levels in optic neuritis and demyelinating disorders. Relation to paraclinical findings and demographic characteristics

The importance of vitamin-D in preventing multiple sclerosis(MS) and reducing disease severity in MS is becoming increasingly accepted. The study examines 25-hydroxyvitamin-D (25HVITD) levels in acute optic neuritis(ON) patients compared to levels in MS patients. 25HVITD levels as a predictor for paraclinical findings (MRI and CSF findings) and risk of RRMS in ON is estimated

Sensitive Assessment of Acute Optic Neuritis by a New Digital Flicker Test (.pdf)

ON is primarily a clinical diagnosis but clinical tests with increased sensitivity, and tests which predict MS risk in the ON patients, are needed. The Aulhorn flicker test was shown in the 1980's to effectively diagnose acute ON1. The aim of this study was to examine the applicability of a new, digitalized version of the analog test for examination of acute optic neuritis (ON)

Functional-structural assessment of the optic pathways in patients with optic neuritis

The aim of this study is to evaluate whether spectral domain optical coherence tomography (SD-OCT) and multifocal visual evoked potential (mfVEP) are potentially better biomarkers than conventional fuel field visual evoked potential (ffVEP) in diagnosing Optic Neuritis (ON)