Effectiveness of dermoscopy in skin cancer diagnosis

Clinical Inquiries question: Does dermoscopy improve the effectiveness of skin cancer diagnosis when used for skin cancer screening? Evidence-based answer: Dermoscopy added to visual inspection is more accurate than visual inspection alone in the diagnosis of melanoma and basal cell carcinoma (BCC). However, there is insufficient evidence to draw conclusions on the effectiveness of dermoscopy in the diagnosis of squamous cell carcinoma (SCC; strength of recommendation B: based on systematic reviews of randomized controlled trials [RCTs], and prospective and retrospective observational studies).Sydney Davis, MD; Cleveland Piggott, MD, MPH; Corey Lyon, DO; Kristen DeSanto, MSLS, MS, RD, AHIPDr Davis is a resident family physician, Dr Piggott is Assistant Professor and Director of Diversity & Health Equity for Family Medicine, Dr Lyon is Associate Professor in the Department of Family Medicine, and Ms DeSanto is Clinical Librarian in the Strauss Health Sciences Library, all at the University of Colorado in Denver.Includes bibliographical reference

Incorporating microorganisms into polymer layers provides bioinspired functional living materials

Artificial two-dimensional biological habitats were prepared from porous polymer layers and inoculated with the fungus Penicillium roqueforti to provide a living material. Such composites of classical industrial ingredients and living microorganisms can provide a novel form of functional or smart materials with capability for evolutionary adaptation. This allows realization of most complex responses to environmental stimuli. As a conceptual design, we prepared a material surface with self-cleaning capability when subjected to standardized food spill. Fungal growth and reproduction were observed in between two specifically adapted polymer layers. Gas exchange for breathing and transport of nutrient through a nano-porous top layer allowed selective intake of food whilst limiting the microorganism to dwell exclusively in between a confined, well-enclosed area of the material. We demonstrated a design of such living materials and showed both active (eating) and waiting (dormant, hibernation) states with additional recovery for reinitiation of a new active state by observing the metabolic activity over two full nutrition cycles of the living material (active, hibernation, reactivation). This novel class of living materials can be expected to provide nonclassical solutions in consumer goods such as packaging, indoor surfaces, and in biotechnology