78 research outputs found
Variação da contagem de células somáticas de rebanhos de acordo com o isolamento de Staphylococcus aureus e Streptococcus agalactiae em amostras de leite do tanque de expansão.
Variação na produção de leite de rebanhos bovinos da raça holandesa de acordo com o isolamento de Staphylococcus aureus e Streptococcus agalactiae em amostras de leite do tanque de expansão.
A phase II dose‑escalation trial of perioperative desmopressin (1‑desamino‑8‑D‑arginine vasopressin) in breast cancer patients
Desmopressin (dDAVP) is a well-known peptide analog of the antidiuretic hormone vasopressin, used to prevent excessive bleeding during surgical procedures. dDAVP increases hemostatic mediators, such as the von Willebrand factor (vWF), recently considered a key element in resistance to metastasis. Studies in mouse models and veterinary trials in dogs with locally-advanced mammary tumors demonstrated that high doses of perioperative dDAVP inhibited lymph node and early blood-borne metastasis and significantly prolonged survival. We conducted a phase II dose-escalation trial in patients with breast cancer, administering a lyophilized formulation of dDAVP by intravenous infusion in saline, 30–60 min before and 24 h after surgical resection. Primary endpoints were safety and tolerability, as well as selection of the best dose for cancer surgery. Secondary endpoints included surgical bleeding, plasma levels of vWF, and circulating tumor cells (CTCs) as measured by quantitative PCR of cytokeratin-19 transcripts. Only 2 of a total of 20 patients experienced reversible adverse events, including hyponatremia (grade 4) and hypersensitivity reaction (grade 2). Reactions were adequately managed by slowing the infusion rate. A reduced intraoperative bleeding was noted with increasing doses of dDAVP. Treatment was associated with higher vWF plasma levels and a postoperative drop in CTC counts. At the highest dose level evaluated (2 μg/kg) dDAVP appeared safe when administered in two slow infusions of 1 μg/kg, before and after surgery. Clinical trials to establish the effectiveness of adjunctive perioperative dDAVP therapy are warranted. This trial is registered on www.clinicaltrials.gov (NCT01606072).Facultad de Ciencias Médica
Epidemiological role of humans, dogs and cats in the transmission of Trypanosoma cruzi in a central area of Argentina
Trypanosoma cruzi in the anal glands of urban opossums: I- isolation and experimental infections
Estudos sôbre reservatórios e vetores silvestres do Trypanosoma cruzi: XVII. Contribuição para o estudo dos focos naturais da tripanossomose americana, com especial referência à região nordeste do Estado de São Paulo, Brasil
Investigación de vectores y reservorios en brote de Chagas agudo por posible transmisión oral en Aguachica, Cesar, Colombia
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