On the solar cycle dependence of the amplitude modulation characterizing the mid-latitude sporadic E layer diurnal periodicity

Spectral analyses are employed to investigate how the diurnal periodicity of the critical frequency of the sporadic E (Es) layer varies with solar activity. The study is based on ionograms recorded at the ionospheric station of Rome (41.8°N, 12.5°E), Italy, from 1976 to 2009, a period of time covering three solar cycles. It was confirmed that the diurnal periodicity is always affected by an amplitude modulation with periods of several days, which is the proof that Es layers are affected indirectly by planetary waves through their non linear interaction with atmospheric tides at lower altitudes. The most striking features coming out from this study is however that this amplitude modulation is greater for high-solar activity than for low-solar activity

On the influence of solar activity on the mid-latitude sporadic E layer

To investigate the influence of solar cycle variability on the sporadic E layer (Es), hourly measurements of the critical frequency of the Es ordinary mode of propagation, foEs, and of the blanketing frequency of the Es layer, fbEs, recorded from January 1976 to December 2009 at the Rome (Italy) ionospheric station (41.8° N, 12.5° E), were examined. The results are: (1) a high positive correlation between the F10.7 solar index and foEs as well as between F10.7 and fbEs, both for the whole data set and for each solar cycle separately, the correlation between F10.7 and fbEs being much higher than the one between F10.7 and foEs; (2) a decreasing long-term trend of the F10.7, foEs and fbEs time series, with foEs decreasing more rapidly than F10.7 and fbEs; (3) clear and statistically significant peaks at 11 years in the foEs and fbEs time series, inferred from Lomb-Scargle periodograms

New approaches in the development of a vaccine for mucosal candidiasis: progress and challenges

The commensal fungus Candida albicans causes mucosal candidiasis in the rapidly expanding number of immunocompromised patients. Mucosal candidiasis includes oropharyngeal, esophageal, gastrointestinal, and vaginal infections. Vulvovaginal candidiasis (VVC) and antimycotic-refractory recurrent VVC is a frequent problem in healthy childbearing women. Both these mucosal infections can affect the quality of life and finding new therapeutical and preventive approaches is a challenge. A vaccine against candidal infections would be a new important tool to prevent and/or cure mucosal candidiasis and would be of benefit to many patients. Several Candida antigens have been proposed as vaccine candidates including cell wall components and virulence factors. Here we discuss the recent progress and problems associated with vaccination against mucosal candidiasis

The IONORT-ISP-WC system: inclusion of an electron collision frequency model for the D-layer

The IONORT-ISP system (IONOspheric Ray-Tracing – IRI-SIRMUP-PROFILES) was recently developed and tested by comparing the measured oblique ionograms over the radio link between Rome (41.89ºN, 12.48ºE), Italy, and Chania (35.51ºN, 24.02ºE), Greece, with the IONORT-ISP simulated oblique ionograms (Settimi et al., 2013). The present paper describes an upgrade of the system to include: a) electron-neutral collision have been included by using a collision frequency model that consists of a double exponential profile; b) the ISP three dimensional (3-D) model of electron density profile grid has been extended down to the altitude of the D-layer; c) the resolution in latitude and longitude of the ISP 3-D model of electron density profile grid has been increased from 2°x2° to 1°x1°. Based on these updates, a new software tool called IONORT-ISP-WC (WC means with collisions) was developed, and a database of 33 IONORT-ISP-WC synthesized oblique ionograms calculated for single (1-hop paths) and multiple (3-hop paths) ionospheric reflections. The IONORT-ISP-WC simulated oblique ionograms were compared with the IONORT-IRI-WC synthesized oblique ionograms, generated by applying IONORT in conjunction with the International Reference Ionosphere (IRI) 3-D electron density grid, and the observed oblique ionograms over the aforementioned radio link. The results obtained show that (1) during daytime, for the lower ionospheric layers, the traces of the synthesized ionograms are cut away at low frequencies because of HF absorption; (2) during night-time, for the higher ionospheric layers, the traces of the simulated ionograms at low frequencies are not cut off (very little HF absorption); (3) the IONORT-ISP-WC MUF values are more accurate than the IONORT-IRI-WC MUF values

foF2 prediction in Rome observatory

A prediction procedure of the hourly values of the critical frequency of the F2 ionospheric layer, foF2, based on the local geomagnetic index ak, is presented. The geomagnetic index utilised is the time-weighted accumulation magnetic index ak(τ) based on recent past history of the index ak. It is utilised an empirical relationship between the log(NmF2(t)/ NmF2M), where NmF2(t) is the hourly maximum electron density at the F2 peak layer and NmF2M is its 'quiet' value, and the time weighted magnetic index. The prediction of foF2 is calculated during periods of severe magnetic activity in the current solar cycle 23 in Rome observatory

The COMPLEIK subroutine of the IONORT-ISP system for calculating the non-deviative absorption: A comparison with the ICEPAC formula

The present paper proposes to discuss the ionospheric absorption, assuming a quasi-flat layered ionospheric medium, with small horizontal gradients. A recent complex eikonal model [Settimi et al., 2013b] is applied, useful to calculate the absorption due to the ionospheric D-layer, which can be approximately characterized by a linearized analytical profile of complex refractive index, covering a short range of heights between h1= 50 km and h2= 90 km. Moreover, Settimi et al. [2013c] have already compared the complex eikonal model for the D-layer with the analytical Chapman’s profile of ionospheric electron density; the corresponding absorption coefficient is more accurate than Rawer’s theory [1976] in the range of middle critical frequencies. Finally, in this paper, the simple complex eikonal equations, in quasi-longitudinal (QL) approximation, for calculating the non-deviative absorption coefficient due to the propagation across the D-layer are encoded into a so called COMPLEIK (COMPLex EIKonal) subroutine of the IONORT (IONOspheric Ray-Tracing) program [Azzarone et al., 2012]. The IONORT program, which simulates the three-dimensional (3-D) ray-tracing for high frequencies (HF) waves in the ionosphere, runs on the assimilative ISP (IRI-SIRMUP-P) discrete model over the Mediterranean area [Pezzopane et al., 2011]. As main outcome of the paper, the simple COMPLEIK algorithm is compared to the more elaborate semi-empirical ICEPAC formula [Stewart, undated], which refers to various phenomenological parameters such as the critical frequency of E-layer. COMPLEIK is reliable just like the ICEPAC, with the advantage of being implemented more directly. Indeed, the complex eikonal model depends just on some parameters of the electron density profile, which are numerically calculable, such as the maximum height

Testing the three-dimensional IRI-SIRMUP-P mapping of the ionosphere for disturbed periods

This paper describes the three-dimensional (3-D) electron density mapping of the ionosphere given as output by the assimilative IRI-SIRMUP-P (ISP) model for three different geomagnetic storms. Results of the 3-D model are shown by comparing the electron density profiles given by the model with the ones measured at two testing ionospheric stations: Roquetes (40.8 °N,0.5 °E), Spain, and San Vito (40.6°N,17.8 °E), Italy. The reference ionospheric stations from which the autoscaled foF2 and M(3000)F2 data as well as the real-time vertical electron density profiles are assimilated by the ISP model are those of El Arenosillo (37.1 °N,353.3° E), Spain, Rome (41.8 °N,12.5 °E), and Gibilmanna (37.9° N,14.0 °E), Italy. Overall, the representation of the ionosphere made by the ISP model is better than the climatological representation made by only the IRI-URSI and the IRI-CCIR models. However, there are few cases for which the assimilation of the autoscaled data from the reference stations causes either a strong underestimation or a strong overestimation of the real conditions of the ionosphere, which is in these cases better represented by only the IRI-URSI model. This ISP misrepresentation is mainly due to the fact that the reference ionospheric stations covering the region mapped by the model turn out to be few, especially for disturbed periods when the ionosphere is very variable both in time and in space and hence a larger number of stations would be required. The inclusion of new additional reference ionospheric stations could surely smooth out this concern

Testing the IONORT-ISP system: A comparison between synthesized and measured oblique ionograms

The three-dimensional (3-D) electron density representation of the ionosphere computed by the assimilative IRI-SIRMUP-P (ISP) model was tested using IONORT (IONOspheric Ray-Tracing), a software application for calculating a 3-D ray-tracing for high frequency (HF) waves in the ionospheric medium. A radio link was established between Rome (41.8°N, 12.5°E) in Italy, and Chania (35.7°N, 24.0°E) in Greece, within the ISP validity area, and for which oblique soundings are conducted. The ionospheric reference stations, from which the autoscaled foF2 and M(3000)F2 data and real-time vertical electron density profiles were assimilated by the ISP model, were Rome (41.8°N, 12.5°E) and Gibilmanna (37.9°N, 14.0°E) in Italy, and Athens (38.0°N, 23.5°E) in Greece. IONORT was used, in conjunction with the ISP and the International Reference Ionosphere (IRI) 3-D electron density grids, to synthesize oblique ionograms. The comparison between synthesized and measured oblique ionograms, both in terms of the ionogram shape and the maximum usable frequency characterizing the radio path, demonstrates both that the ISP model can more accurately represent real conditions in the ionosphere than the IRI, and that the ray-tracing results computed by IONORT are reasonably reliable

Description of ionospheric disturbances observed by Vertical Ionospheric Sounding at 3 MHz

High Frequency radio waves reflected by the ionosphere can provide a relevant amount of information within the composite received signal. The ionosphere is indeed a frequency dispersive, bi-refractive, absorbing medium, in which multipath propagation occurs due to disturbance on a varied time-spatial scale. On the time-spatial level of Small Scale Disturbances (SSD) the ionosphere dynamics, detectable by Vertical Ionospheric Sounding (VIS), is mainly dependent on wrinkled layers acting as multi-reflectors. The present paper discusses different aspects of the effects of multipath fading suffered by the wave along the propagation path and potentially associated with SSD. To achieve these objectives, a VIS campaign at a fixed frequency of 3.0 MHz was conducted at the ionospheric observatory in Rome (Latitude 41.8 N; Longitude 12.5 E), by collecting a series of measurements of the power variations in received echo signals recorded between two consecutive ionograms whose sounding repetition rate was set to 15 min. The obtained results show that: 1) the fading suffered by the wave follows either a Rayleigh trend or a Nakagami-Rice trend, or a mix of them, the mixed case being the most frequent (about 65 % of the analysed cases); 2) the predominant periodicities characterizing the power variation are less than 25 s; such values are compatible with the small scale ionospheric disturbances; 3) for all the 24 hours of the day the ionospheric reflector is pretty stable and for time intervals of 10-30 s the periods of stability occur with a percentage of occurrence ranging between 55% and 95 %; for time intervals of 190- 210 s the periods of stability occur instead with a percentage of occurrence ranging between 5% and 54 %

Minipuberty in Male Full-term Neonates Appropriate and Small for Gestational Age and in Preterm Babies: Data from a Single Centre

Objective: The postnatal activation of the hypothalamic-pituitary-gonadal (HPG) axis is usually known as “minipuberty”. There are still open questions about its biological function and significance depending on sex, gestational age (GA) and birth weight (BW) with few available longitudinal data. Methods: A single-centre, longitudinal study to quantify urinary follicle stimulating hormone (uFSH), luteinizing hormone (uLH) and testosterone (uTs) in male neonates. Neonates were enrolled and stratified into three subgroups: full-term boys appropriate for GA (FT AGA); FT boys with BW ≤3rd centile [FT small for gestational age (SGA)]; and preterm (PT) boys ≤33 weeks of GA. Urinary hormones were correlated to simultaneous auxological parameters, linear growth and external genitalia at scheduled time-points. Results: Forty-six boys were recruited, with subgroup sizes FT AGA n=23, FT SGA n=11 and PT n=12. PT boys display a pulsatile pattern of urinary gonadotropins (uGns) with higher levels of uLH and a gradual increase of uTs. Testicular descent started from 29-32 weeks with the peak of uTs. During the first 12-months post-term age (PTA), FT AGA boys displayed a better linear growth (p<0.05). PT showed higher uGns levels until 3-months PTA. PT babies had higher uLH levels than FT AGA, with a peak at 7 and 30 days, during the first 90 days of life (p<0.001) and higher uTs levels. Correlation analysis between penile growth of all neonates and uTs was significant (p=0.04) but not within subgroups. Conclusion: This study investigated postnatal HPG axis activation in term and PT infants. Minipuberty may involve an early window of opportunity to evaluate the functionality of the HPG axis. Further studies with a long-term follow-up are needed with a special focus on possible consequences of GA and BW