A Case-Study Plant for a Sustainable Redevelopment of Buildings Based on Storage and Reconversion of Hydrogen Generated by Using Solar Energy

In todays process of decarbonisation and transition to a green economy based on distributed and sustainable energy production, hydrogen is considered the most promising energy carrier, thanks to its multiple properties. It is clean, versatile and has a high combustion efficiency and more importantly, renewable energy could be used as a primary source for hydrogen production near the end use point, making full use of local energy potential. Nevertheless, the current cost of its technology still requires further research and development, necessary to obtain its rapid and effective launch onto the market. Moreover, hydrogen storage and distribution infrastructures, fundamental to make it usable and competitive, are currently lacking.In this framework, the paper analyses a photovoltaic (PV) system, equipped with hydrogen storage and reconversion subsystems. The technological plant is basically aimed to be easily integrated into buildings for their sustainable redevelopment. At this stage, the presented case study was designed to supply a part of electrical needs of the Mediterranea University of Reggio Calabria.In brief, starting from the PV generation of electricity, hydrogen is obtained through electrolytic production, which is stored and then reconverted into electricity by using fuel cells. The study clearly meets the main goals of the 2030 Agenda for sustainable development. Un caso studio di impianto per la riqualificazione sostenibile degli edifici basato sullo stoccaggio e sulla riconversione dell’idrogeno prodotto usando l’energia solareNell'odierno processo di decarbonizzazione e transizione verso un'economia verde basata sulla produzione di energia distribuita e sostenibile, l'idrogeno è considerato il vettore energetico più promettente, grazie alle sue molteplici proprietà: è pulito, versatile e ha un'alta efficienza di combustione. In particolare, l'energia rinnovabile potrebbe essere utilizzata come fonte primaria per la produzione di idrogeno vicino al punto di utilizzo finale, sfruttando appieno il potenziale energetico locale. Tuttavia, l'attuale costo della sua tecnologia richiede ancora ulteriori ricerche e sviluppi, necessari per ottenere la sua rapida ed efficace penetrazione nel mercato. Inoltre, al momento le infrastrutture di stoccaggio e distribuzione dell'idrogeno, fondamentali per renderlo utilizzabile e competitive, sono ancora lacunose.In questo scenario, il lavoro analizza un sistema fotovoltaico (PV), dotato di sottosistemi di stoccaggio e riconversione dell'idrogeno. L'impianto tecnologico è pensato per essere facilmente integrato negli edifici per una loro riqualificazione sostenibile; in questa fase, il caso di studio testato era finalizzato alla alimentazione di una parte delle utenze elettriche dell'Università Mediterranea di Reggio Calabria. In breve, a partire dalla generazione fotovoltaica di elettricità, l'idrogeno viene ottenuto attraverso la produzione elettrolitica, immagazzinato e poi riconvertito in elettricità utilizzando le celle a combustibile. Lo studio è chiaramente in linea con i principali obiettivi dell'Agenda 2030 per uno sviluppo sostenibile.In todays process of decarbonisation and transition to a green economy based on distributed and sustainable energy production, hydrogen is considered the most promising energy carrier, thanks to its multiple properties. It is clean, versatile and has a high combustion efficiency and more importantly, renewable energy could be used as a primary source for hydrogen production near the end use point, making full use of local energy potential. Nevertheless, the current cost of its technology still requires further research and development, necessary to obtain its rapid and effective launch onto the market. Moreover, hydrogen storage and distribution infrastructures, fundamental to make it usable and competitive, are currently lacking.In this framework, the paper analyses a photovoltaic (PV) system, equipped with hydrogen storage and reconversion subsystems. The technological plant is basically aimed to be easily integrated into buildings for their sustainable redevelopment. At this stage, the presented case study was designed to supply a part of electrical needs of the Mediterranea University of Reggio Calabria.In brief, starting from the PV generation of electricity, hydrogen is obtained through electrolytic production, which is stored and then reconverted into electricity by using fuel cells. The study clearly meets the main goals of the 2030 Agenda for sustainable development. Un caso studio di impianto per la riqualificazione sostenibile degli edifici basato sullo stoccaggio e sulla riconversione dell’idrogeno prodotto usando l’energia solareNell'odierno processo di decarbonizzazione e transizione verso un'economia verde basata sulla produzione di energia distribuita e sostenibile, l'idrogeno è considerato il vettore energetico più promettente, grazie alle sue molteplici proprietà: è pulito, versatile e ha un'alta efficienza di combustione. In particolare, l'energia rinnovabile potrebbe essere utilizzata come fonte primaria per la produzione di idrogeno vicino al punto di utilizzo finale, sfruttando appieno il potenziale energetico locale. Tuttavia, l'attuale costo della sua tecnologia richiede ancora ulteriori ricerche e sviluppi, necessari per ottenere la sua rapida ed efficace penetrazione nel mercato. Inoltre, al momento le infrastrutture di stoccaggio e distribuzione dell'idrogeno, fondamentali per renderlo utilizzabile e competitive, sono ancora lacunose.In questo scenario, il lavoro analizza un sistema fotovoltaico (PV), dotato di sottosistemi di stoccaggio e riconversione dell'idrogeno. L'impianto tecnologico è pensato per essere facilmente integrato negli edifici per una loro riqualificazione sostenibile; in questa fase, il caso di studio testato era finalizzato alla alimentazione di una parte delle utenze elettriche dell'Università Mediterranea di Reggio Calabria. In breve, a partire dalla generazione fotovoltaica di elettricità, l'idrogeno viene ottenuto attraverso la produzione elettrolitica, immagazzinato e poi riconvertito in elettricità utilizzando le celle a combustibile. Lo studio è chiaramente in linea con i principali obiettivi dell'Agenda 2030 per uno sviluppo sostenibile

DISTRETTI ENERGETICI: UNO STUDIO SU UN QUARTIERE DI UNA CITTÀ DELL’ITALIA MERIDIONALE

Nowadays the energy transition, which implies the design of a new energy supply and distribution model based on RES, is an urgent course of action. Not only is it crucial to tackle climate change issues but it is also an opportunity to generate new technical, economic and social development possibilities. In this framework, the implementation of new structures of collective and collaborative economy, such as energy districts and communities, is encouraged by the European Union's development programs as a crucial strategy to mitigate both climate change crisis and economic inequalities as well as socio-environmental injustices. With a view to providing a contribution to the studies addressing the effectiveness of these new energy management structures, especially in Mediterranean climates, this work proposes an analysis focused on a neighborhood of a city located in the Southern Italy. The results showed that the implementation of RES in an energy district perspective, according to the feasibility granted by the neighborhood features, allowed the balance between energy productivity and needs to be reached

Targeting unfolded protein response reverts ER stress and ER Ca2+ homeostasis in cardiomyocytes expressing the pathogenic variant of Lamin A/C R321X

Background: We previously demonstrated that an Italian family affected by a severe dilated cardiomyopathy (DCM) with history of sudden deaths at young age, carried a mutation in the Lmna gene encoding for a truncated variant of the Lamin A/C protein (LMNA), R321X. When expressed in heterologous systems, such variant accumulates into the endoplasmic reticulum (ER), inducing the activation of the PERK-CHOP pathway of the unfolded protein response (UPR), ER dysfunction and increased rate of apoptosis. The aim of this work was to analyze whether targeting the UPR can be used to revert the ER dysfunction associated with LMNA R321X expression in HL-1 cardiac cells. Methods: HL-1 cardiomyocytes stably expressing LMNA R321X were used to assess the ability of 3 different drugs targeting the UPR, salubrinal, guanabenz and empagliflozin to rescue ER stress and dysfunction. In these cells, the state of activation of both the UPR and the pro-apoptotic pathway were analyzed monitoring the expression levels of phospho-PERK, phospho-eIF2α, ATF4, CHOP and PARP-CL. In addition, we measured ER-dependent intracellular Ca2+ dynamics as indicator of proper ER functionality. Results: We found that salubrinal and guanabenz increased the expression levels of phospho-eIF2α and downregulated the apoptosis markers CHOP and PARP-CL in LMNA R321X-cardiomyocytes, maintaining the so-called adaptive UPR. These drugs also restored ER ability to handle Ca2+ in these cardiomyocytes. Interestingly, we found that empagliflozin downregulated the apoptosis markers CHOP and PARP-CL shutting down the UPR itself through the inhibition of PERK phosphorylation in LMNA R321X-cardiomyocytes. Furthermore, upon empagliflozin treatment, ER homeostasis, in terms of ER ability to store and release intracellular Ca2+ was also restored in these cardiomyocytes. Conclusions: We provided evidence that the different drugs, although interfering with different steps of the UPR, were able to counteract pro-apoptotic processes and to preserve the ER homeostasis in R321X LMNA-cardiomyocytes. Of note, two of the tested drugs, guanabenz and empagliflozin, are already used in the clinical practice, thus providing preclinical evidence for ready-to-use therapies in patients affected by the LMNA R321X associated cardiomyocytes

Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold

Proper sensing of ambient temperature is of utmost importance for the survival of euthermic animals, including humans. While considerable progress has been made in our understanding of temperature sensors and transduction mechanisms, the higher-order neural circuits processing such information are still only incompletely understood. Using intersectional genetics in combination with circuit tracing and functional neuron manipulation, we identified Kcnip2-expressing inhibitory (Kcnip2GlyT2) interneurons of the mouse spinal dorsal horn as critical elements of a neural circuit that tunes sensitivity to cold. Diphtheria toxin-mediated ablation of these neurons increased cold sensitivity without affecting responses to other somatosensory modalities, while their chemogenetic activation reduced cold and also heat sensitivity. We also show that Kcnip2GlyT2 neurons become activated preferentially upon exposure to cold temperatures and subsequently inhibit spinal nociceptive output neurons that project to the lateral parabrachial nucleus. Our results thus identify a hitherto unknown spinal circuit that tunes cold sensitivity. Keywords: circuit; cold; cold allodynia; cold analgesia; cooling; dre recombinase; interneuron; intersectional gene targeting; kcnip2; pai

A web survey to evaluate the thermal stress among healthcare workers during the COVID-19 pandemic in Italy

COVID 19 is a major planetary emergency and intense workloads and the potential heat stress create critical conditions for healthcare workers. A web survey was carried out in Italy during summer 2020 as part of WORKLIMATE project with the aim of assessing the interaction between Personal Protective Equipment (PPE) and heat stress in healthcare workers. Preliminary results on 191 questionnaires show an increase of heat stress perception in the areas covered by PPE determining symptoms such as thirst, sweating and general distress. This information could be useful to allow preventive measure to safeguard health and productivity of these workers

The interplay among psychopathology, personal resources, context-related factors and real-life functioning in schizophrenia: stability in relationships after 4 years and differences in network structure between recovered and non-recovered patients

Improving real-life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness-related variables, personal resources, context-related factors and real-life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4-year follow-up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow-up. In addition, we compared the network structure of patients who were classified as recovered at follow-up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow-up study. The network structure did not change significantly from baseline to follow-up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow-up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non-recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self-reinforcing networks of symptoms and dysfunctions in people with schizophrenia

The interplay among psychopathology, personal resources, context-related factors and real-life functioning in schizophrenia: stability in relationships after 4 years and differences in network structure between recovered and non-recovered patients

Improving real-life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness-related variables, personal resources, context-related factors and real-life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4-year follow-up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow-up. In addition, we compared the network structure of patients who were classified as recovered at follow-up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow-up study. The network structure did not change significantly from baseline to follow-up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow-up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non-recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self-reinforcing networks of symptoms and dysfunctions in people with schizophrenia

Greenhouse Gas Balance in the City of Reggio Calabria and Assessment of the Effects of Measures of Emission Reduction and Absorption

Climate change and its ascertained attribution to anthropic activity need to be tackled with extreme urgency and must not be postponed. The need to reduce greenhouse gas emissions require a change in the energy paradigm, mainly affecting the construction and mobility sectors. Countries need to move towards climate neutrality with a widespread adoption of innovative models, systems, and technologies, reducing dependence on non-renewable sources and increasing energy efficiency. Measures to be adopted to achieve the prefixed decarbonization targets should involve, in addition to central governments, local communities. In this paper, in order to contribute to the definition of mitigation measures by the local administration, the balance of emissions and removal of greenhouse gases, assessed following the IPCC guidelines, for an Italian city (Reggio Calabria) on the date of 1 January 2020 is presented. Several hypotheses concerning reduction measures to be applied to the building and transport sectors, together with absorption interventions, have been developed and we have analyzed the effectiveness of each of them and their global effects on 1 January 2030. The proposed measures allow a reduction of 17% of total emissions, indicating that to reach carbon neutrality in 2050, more incisive and wide range interventions are required

Effects of the SARS-CoV-2 Pandemic on CO₂ Emissions in the Port Areas of the Strait of Messina

The Strait of Messina is characterised by a significant ship flow, especially of ferries, between its two shores. The ferry services involve four harbours, located on the Sicilian and Calabrian shores. During the epidemic emergency related to the SARS-CoV-2 virus, due to the restrictions adopted to counteract the spread of the infection, a significant reduction in ferry activities and vehicle flow occurred. These circumstances made flow data, related to different actual scenarios, available and allowed the assessment of the environmental impact of the port area. Therefore, the port area became a noteworthy case study, suited to draw conclusions regarding possible future courses of action designed to curb greenhouse gas emissions in these types of settlements. In the study, in order to assess the effect of different levels of human activity on pollutant emissions, the total CO2 emissions from ferry activities in two successive years, 2019 before the spread of the virus and 2020 when the epidemic was at its peak, were evaluated and compared. The EMEP/EEA methodology was used and, as a result, an overall reduction of 13.2% in CO2eq yearly emission rates was observed, with the major reduction of 2784 tCO2eq due to maritime traffic

Electric Load Influence on Performances of a Composite Plant for Hydrogen Production from RES and its Conversion in Electricity

The analysis here presented investigates the influence of electrical load on the operational performances of a plant for hydrogen production from solar energy and its conversion in electricity via a fuel cell. The plant is an actual one, currently under construction, in Reggio Calabria (Italy), at the site of the Mediterranean university campus; it is composed of a Renewable Energy Source (RES) section (photovoltaic panels), a hydrogen production section, and a fuel cell power section feeding the electrical energy demand of the load. Two different load configurations have been analysed and simulations have been carried out through HomerTM simulation code. Results allow interesting conclusions regarding the plant operation to be drawn. The study could have a remarkable role in supporting further research activities aimed at the assessment of the optimal configuration of this type of pioneering plants, designed for feeding electrical loads, possibly, in a self-sufficient way