Can a Joint Assessment Provide Relevant Information for National/Local Relative Effectiveness Assessments? : An In-Depth Comparison of Pazopanib Assessments

BACKGROUND: In many European jurisdictions, relative effectiveness assessments (REAs) of pharmaceuticals are performed during the reimbursement decision-making process. International collaboration in the production of these assessments may prevent the duplication of information in various jurisdictions. A first pilot of a joint REA (pazopanib for the treatment of renal cell carcinoma) was published in 2011. OBJECTIVE: The objective was to investigate how well the methods used in the joint REA match the methods used in the national/local assessments on the same topic. METHODS: National/local assessments from European jurisdictions, available in English language, were identified through a literature search and an e-mail request to health technology assessment organizations. Data were abstracted from joint and national/local assessments using a structured data abstraction form. Results were compared for differences and similarities. RESULTS: In total, five national/local reports were included (Belgium, England/Wales, France, The Netherlands, and Scotland). The general methods (indication, main comparator, main end points, main trial) were similar. The details of the assessment (e.g., exact wording of indication, additional comparators, additional trials included, and method of indirect comparison), however, varied. Despite these differences, the joint REA included nearly all comparators, end points, trials, and methods of analysis that were used in national/local REA reports. CONCLUSIONS: This study has shown overlap in the methods national/local REA bodies in Europe have chosen for a pazopanib REA for renal cell carcinoma, except for the use and methods of indirect comparisons. Although some additional comparators and outcomes differed between national/local REAs, they can be captured in a comprehensive joint REA

Aspects of the Louvain-la-Neuve results and projects

info:eu-repo/semantics/publishe

Nuclear astrophysics studies with radioactive Beams in Louvain-La-Neuve

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New limits for the 19Ne(p,γ)20Na astrophysical reaction rate from direct measurements using radioactive beams

In explosive stellar hydrogen burning, the hot CNO cycles and the rp-process are mainly linked by the reaction sequence 15O(α, γ)19Ne(p,γ)20Na. Using intense 19Ne radioactive beams, both the 19Ne(p,γ) and the 19Ne(d,n) reaction have been studied. Upper and lower limits for the 19Ne(p,γ) reaction rate have been deduced, allowing to conclude that the 15O(α,γ) reaction is most likely the bottleneck reaction.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Measurements of the 19Ne(p,y) reaction rate using radioactive BEAMS

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First experimental eimit on the Ne19(p,γ)Na20 resonance strength, of astrophysical interest

The 19Ne(p, γ)20Na reaction may influence considerably the reaction flow between the CNO and NeNa mass regions in high temperature hydrogen burning conditions. The 447 keV resonance has been studied by exploiting radioactive 19Ne beams with novel detection techniques to measure β+ -delayed α radioactivity of 20Na nuclei produced in reactions with polyethylene targets. A 90% C.L. upper limit of 18 meV for the resonance strength has been determined and implications for the spin assignment of the 2.646 MeV state in 20Na and the stellar reaction rate are discussed.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

A direct measurement of the 19Ne(p,γ)20Na reaction

The 19 Ne(p,γ); 20 Na reaction may be of considerable influence for the reaction flow between the CNO and NeNa mass region in high temperature hydrogen burning conditions. The proposed low energy resonance at 0.447 MeV has been measured in inverse kinematics with the Louvain‐la‐Neuve ;19 Ne beam, using novel activation techniques. An upper limit to the resonance strength has been determined and the implications for the spin assignment of the 2.646 MeV state in 20 Na as well as for the stellar reaction rate are discussed. © ;1995 American Institute of Physics.info:eu-repo/semantics/publishe

Nuclear reactions of astrophysical interest with radioactive beams

The ARENAS3 facility, coupling the two cyclotrons of Louvain-la-Neuve, is intensively been used over the past years for cross-section measurements of nuclear reactions of astrophysical interest. We will describe the characteristics of the available beams and the experiments going on using these beams. The 19Ne(p,γ)20Na reaction, of considerable importance for the reaction flow between the CNO and the NeNa mass region in high-temperature hydrogen burning conditions, will be discussed in particular. The proposed low-energy resonance at 0.447 MeV has been measured in inverse kinematics using novel activation techniques. An upper limit (90% C.L.) of 18 meV is obtained for the strength of this first particle-unbound state of 20Na together with preliminary values for the strength of the higher excited states. © 1995.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

The 19Ne(p,γ)20Na astrophysical reaction rate determined from measurements with a radioactive beam

The 19Ne(p,γ)20Na as well as the 19Ne(d,n)20Na reaction have been studied in inverse kinematics using 19Ne radioactive beams. Upper and lower limits for the 19Ne(p,γ)20Na astrophysical reaction rate have been deduced, for the first time on the basis of direct experimental data. It is concluded that the transition from the hot-CNO cycle to the rp-process in explosive hydrogen burning is most likely governed by the preceeding 15O(a,γ)19Ne reaction.SCOPUS: ar.jinfo:eu-repo/semantics/publishe