4 research outputs found
High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli
We present a genomewide, high-resolution study of nucleolar-associated chromatin using comparative genome hybridization, deep sequencing, and photoactivation microscopy. We show specific regions from most chromosomes associate with nucleoli. These regions are AT-rich, enriched in repressed genes, and overlap with nuclear lamina-associated loci