Response profile of Medial-network nodes (mean ± SEM).

<p>The BOLD contrast values during the EMO, GRAM, and PLAUEMO tasks (blue shades), and TOM and PLAUTOM tasks (green shades), relative to beep-detection baseline, were extracted in the 6 regions of the Medial network defined in a previous study using the EMO and GRAM tasks (dmPFC, vmPFC, pCC and Left TPJ; blue labels, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054400#pone.0054400-Herv1" target="_blank">[5]</a>). The coloured spheres (4 mm radius) indicate the regions-of-interest. We added the two mentalizing regions of the right hemisphere (R TPJ and R MTG; green labels), uncovered by the addition of the TOM, PLAUTOM and PLAUEMO tasks.</p

One-sample t-tests assessing activations during TOM, PLAUTOM or PLAUEMO, and paired two-sample t-tests assessing the TOM – PLAUTOM differences in the 6 Medial network regions.

<p>Within each task, a Holm-Bonferroni procedure was applied to correct for multiple comparisons (6 null-hypotheses). Asterisks indicate raw or adjusted p-value below 0.05. The m-vmPFC region did not show any significant result, although a trend is present in the TOM – PLAUTOM comparison.</p

Overlap between emotional and ToM sentence processing (in blue).

<p>Three-plane views and surface renderings of the significant activations during language comprehension (conjunction of PLAUTOM and TOM, in warm colors) and ToM sentence comprehension) as compared with a plausibility judgment task on sentences of comparable complexity (TOM - PLAUTOM, in green). The overlap between the TOM task and the emotional sentence classification task (EMO), relative to their matched plausibility judgment tasks (PLAUTOM and PLAUEMO) is rendered or contoured in blue (conjunction analysis, <i>p</i><0.05 FWE). The functional data (SPM t-map) are overlaid on the mean grey matter image of the stereotaxic template (T-80TVS, MNI space). The functional activation threshold was set at <i>p</i><0.05, FWE correction for multiple comparisons. The conjunction was masked so as to include only areas that also differ between the EMO and GRAM tasks (at <i>p</i><0.0001, uncorrected).</p

Behavioral data for the 5 tasks (mean ± SD).

<p>Behavioral data for the 5 tasks (mean ± SD).</p

Stereotaxic peak coordinates (MNI space, coordinates in mm) for the differences between EMO and TOM tasks, relative to their references (PLAUEMO and PLAUTOM).

<p>The T statistic for each peak, and the size of the corresponding activation cluster in number of voxels (8 mm³ volume) are also presented.</p

Average BOLD response of 3 vmPFC regions-of-interest to the 3 different conditions of EMO or TOM (mean ± SEM).

<p>Left: significant region from the EMO and TOM conjunction (a-vmPFC); Centre: region of the Medial network (m-vmPFC); Right: significant region from the EMO – TOM comparison (p-vmPFC).</p

Differences between emotional and ToM sentence processing, as assessed by comparisons between EMO (blue shades) and TOM (green shades), relative to their corresponding plausibility judgment tasks (PLAUEMO and PLAUTOM).

<p>The functional data (SPM t-map) are overlaid on a representative subject in the MNI space, on white matter surface and on axial slices in neurological orientation. The accompanying plots (mean ± SEM) present the SPM contrast values (relative to beep-detection baseline) during the two pairs of sentence comprehension tasks in the regions more active during EMO than TOM (blue lines), and during TOM compared with EMO (green lines), contrasted to the PLAUEMO and PLAUTOM reference tasks. The voxel-wise functional activation threshold was set at <i>p</i><0.05, corrected for multiple comparisons. The [EMO – PLAUEMO] – [TOM – PLAUTOM] contrast, showing regions more active during emotional than ToM speech processing, was masked inclusively by the EMO – GRAM contrast (at <i>p</i><0.0001, uncorrected). The reverse contrast ([TOM – PLAUTOM] – [EMO – PLAUEMO]) was masked inclusively by the TOM – PLAUTOM contrast (at <i>p</i><0.0001, uncorrected).</p

Stereotaxic peak coordinates (MNI space, coordinates in mm, p<0.05 FWE, clusters with more than 10 voxels) for the theory of mind task contrast and conjunction between EMO and TOM tasks, relative to their reference (PLAUEMO and PLAUTOM).

<p>The <i>t</i> statistic for each peak, and the size of the corresponding activation cluster in number of voxels (8 mm³ volume) are also presented.</p