634 research outputs found
Adiabatic evolution on a spatial-photonic Ising machine
Combinatorial optimization problems are crucial for widespread applications
but remain difficult to solve on a large scale with conventional hardware.
Novel optical platforms, known as coherent or photonic Ising machines, are
attracting considerable attention as accelerators on optimization tasks
formulable as Ising models. Annealing is a well-known technique based on
adiabatic evolution for finding optimal solutions in classical and quantum
systems made by atoms, electrons, or photons. Although various Ising machines
employ annealing in some form, adiabatic computing on optical settings has been
only partially investigated. Here, we realize the adiabatic evolution of
frustrated Ising models with 100 spins programmed by spatial light modulation.
We use holographic and optical control to change the spin couplings
adiabatically, and exploit experimental noise to explore the energy landscape.
Annealing enhances the convergence to the Ising ground state and allows to find
the problem solution with probability close to unity. Our results demonstrate a
photonic scheme for combinatorial optimization in analogy with adiabatic
quantum algorithms and enforced by optical vector-matrix multiplications and
scalable photonic technology.Comment: 9 pages, 4 figure
Large-scale photonic Ising machine by spatial light modulation
Quantum and classical physics can be used for mathematical computations that
are hard to tackle by conventional electronics. Very recently, optical Ising
machines have been demonstrated for computing the minima of spin Hamiltonians,
paving the way to new ultra-fast hardware for machine learning. However, the
proposed systems are either tricky to scale or involve a limited number of
spins. We design and experimentally demonstrate a large-scale optical Ising
machine based on a simple setup with a spatial light modulator. By encoding the
spin variables in a binary phase modulation of the field, we show that light
propagation can be tailored to minimize an Ising Hamiltonian with spin
couplings set by input amplitude modulation and a feedback scheme. We realize
configurations with thousands of spins that settle in the ground state in a
low-temperature ferromagnetic-like phase with all-to-all and tunable pairwise
interactions. Our results open the route to classical and quantum photonic
Ising machines that exploit light spatial degrees of freedom for parallel
processing of a vast number of spins with programmable couplings.Comment: https://journals.aps.org/prl/accepted/7007eYb7N091546c41ad4108828a97d5f92006df
Immunodeficiency-associated viral oncogenesis
AbstractSeveral viruses with different replication mechanisms contribute to oncogenesis by both direct and indirect mechanisms in immunosuppressed subjects after solid organ transplantation, after allogeneic stem cell transplantation, or with human immunodeficiency virus (HIV) infection. Epstein–Barr virus (EBV), human papillomavirus (HPV), Kaposi sarcoma herpesvirus (KSHV), human T-cell lymphotropic virus type 1 (HTLV-1) and Merkel cell polyoma virus (MCV) are the main viruses associated with the development of cancer in immunosuppressed patients. Besides being a main cause of immunodeficiency, HIV1 has a direct pro-oncogenic effect. In this review, we provide an update on the association between the condition of acquired immunodeficiency and cancer risk, specifically addressing the contributions to oncogenesis of HPV, MCV, KSHV, HTLV-1, and EBV
Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report.
Abstract
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Introduction:
Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity.
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Conclusion:
An MRI performed at the end of the supplementation period evidenced the clearance of the anal condylomas previously described and no evidence of residual lymphadenopathies. Trials are therefore required to confirm this therapeutic possibility and for a better understanding of the mechanisms by which this specific probiotic formulation interacts with local epithelium when administered by the anal route
Noise-enhanced spatial-photonic Ising machine
Ising machines are novel computing devices for the energy minimization of Ising models. These combinatorial optimization problems are of paramount importance for science and technology, but remain difficult to tackle on large scale by conventional electronics. Recently, various photonics-based Ising machines demonstrated fast computing of a Ising ground state by data processing through multiple temporal or spatial optical channels. Experimental noise acts as a detrimental effect in many of these devices. On the contrary, here we demonstrate that an optimal noise level enhances the performance of spatial-photonic Ising machines on frustrated spin problems. By controlling the error rate at the detection, we introduce a noisy-feedback mechanism in an Ising machine based on spatial light modulation. We investigate the device performance on systems with hundreds of individually-addressable spins with all-to-all couplings and we found an increased success probability at a specific noise level. The optimal noise amplitude depends on graph properties and size, thus indicating an additional tunable parameter helpful in exploring complex energy landscapes and in avoiding getting stuck in local minima. Our experimental results identify noise as a potentially valuable resource for optical computing. This concept, which also holds in different nanophotonic neural networks, may be crucial in developing novel hardware with optics-enabled parallel architecture for large-scale optimizations
Observation of Fermi-Pasta-Ulam-Tsingou Recurrence and Its Exact Dynamics
One of the most controversial phenomena in nonlinear dynamics is the reappearance of initial
conditions. Celebrated as the Fermi-Pasta-Ulam-Tsingou problem, the attempt to understand how these
recurrences form during the complex evolution that leads to equilibrium has deeply influenced the entire
development of nonlinear science. The enigma is rendered even more intriguing by the fact that integrable
models predict recurrence as exact solutions, but the difficulties involved in upholding integrability for a
sufficiently long dynamic has not allowed a quantitative experimental validation. In natural processes,
coupling with the environment rapidly leads to thermalization, and finding nonlinear multimodal systems
presenting multiple returns is a long-standing open challenge. Here, we report the observation of more than
three Fermi-Pasta-Ulam-Tsingou recurrences for nonlinear optical spatial waves and demonstrate the
control of the recurrent behavior through the phase and amplitude of the initial field. The recurrence period
and phase shift are found to be in remarkable agreement with the exact recurrent solution of the nonlinear
Schrödinger equation, while the recurrent behavior disappears as integrability is lost. These results identify
the origin of the recurrence in the integrability of the underlying dynamics and allow us to achieve one of
the basic aspirations of nonlinear dynamics: the reconstruction, after several return cycles, of the exact
initial condition of the system, ultimately proving that the complex evolution can be accurately predicted in
experimental conditions
Facilitating the Decentralised Exchange of Cryptocurrencies in an Order-Driven Market
This article discusses a protocol to facilitate decentralised exchanges on an order-driven market through a consortium of market services operators. We discuss whether this hybrid protocol combining a centralised initiation phase with a decentralised execution phase outperforms fully centralised exchanges with regards to efficiency and security. Here, a fully efficient and fully secure protocol is defined as one where traders incur no trading costs or opportunity costs and counterparty risk is absent. We devise a protocol addressing the main downsides in the decentralised exchange process that uses a facilitating distributed ledger, maintains an order book and monitors the order status in real-time to provide accurate exchange rate information and performance scoring of participants. We show how performance ratings can lower opportunity costs and how a rolling benchmark rate of verifiable trades can be used to establish a trustworthy exchange rate between cryptocurrencies. The formal validation of the proposed technical mechanisms is the subject of future work
Early and late follow-up of untreated traumatic aortic lesion: a support to delayed surgery
Fuente Fuente, Carlos;Montes Gil, Antonio;Periel Piquer, Montserra
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