3 research outputs found
A geodatabase for the geological map of Tuscany
ACCEPTED as Oral Presentation
in session: "T22.01 - National / international geological map databases
Prognostic Value and Relative Cutoffs of Triglycerides Predicting Cardiovascular Outcome in a Large RegionalâBased Italian Database
Background Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, the exact level at which risk begins to rise is unclear. The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension has conceived a protocol aimed at searching for the prognostic cutoff value of triglycerides in predicting cardiovascular events in a large regionalâbased Italian cohort. Methods and Results Among 14â189 subjects aged 18 to 95âyears followedâup for 11.2 (5.3â13.2) years, the prognostic cutoff value of triglycerides, able to discriminate combined cardiovascular events, was identified by means of receiver operating characteristic curve. The conventional (150âmg/dL) and the prognostic cutoff values of triglycerides were used as independent predictors in separate multivariable Cox regression models adjusted for age, sex, body mass index, total and highâdensity lipoprotein cholesterol, serum uric acid, arterial hypertension, diabetes, chronic renal disease, smoking habit, and use of antihypertensive and lipidâlowering drugs. During 139â375 personâyears of followâup, 1601 participants experienced cardiovascular events. Receiver operating characteristic curve showed that 89âmg/dL (95% CI, 75.8â103.3, sensitivity 76.6, specificity 34.1, P<0.0001) was the prognostic cutoff value for cardiovascular events. Both cutoff values of triglycerides, the conventional and the newly identified, were accepted as multivariate predictors in separate Cox analyses, the hazard ratios being 1.211 (95% CI, 1.063â1.378, P=0.004) and 1.150 (95% CI, 1.021â1.295, P=0.02), respectively. Conclusions Lower (89âmg/dL) than conventional (150âmg/dL) prognostic cutoff value of triglycerides for cardiovascular events does exist and is associated with increased cardiovascular risk in an Italian cohort