Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

Chronic inflammation, a decline in immune responsiveness, and reduced cardiovascular function are all associated with aging, but the relationships among these phenomena remain unclear. Here, we longitudinally profiled a total of 84 signaling conditions in 91 young and older adults and observed an age-related reduction in cytokine responsiveness within four immune cell lineages, most prominently T cells. The phenotype can be partially explained by elevated baseline levels of phosphorylated STAT (pSTAT) proteins and a different response capacity of naive versus memory T cell subsets to interleukin 6 (IL-6), interferon α (IFN-α), and, to a lesser extent, IL-21 and IFN-γ. Baseline pSTAT levels tracked with circulating levels of C-reactive protein (CRP), and we derived a cytokine response score that negatively correlates with measures of cardiovascular disease, specifically diastolic dysfunction and atherosclerotic burden, outperforming CRP. Thus, we identified an immunological link between inflammation, decreased cell responsiveness in the JAK-STAT pathway, and cardiovascular aging. Targeting chronic inflammation may ameliorate this deficiency in cellular responsiveness and improve cardiovascular function

Faith-Based and Community Initiative: Service Providers and Approaches to Studying Service Outcomes

President Bush\u27s Executive Orders to establish Centers of Faith-Based and Community Initiatives have encouraged the use of faith-based organizations (FBOs) as service providers in a range of federally funded programs. New federal rules and regulations are removing barriers so that FBOs can participate in these programs. Yet, there is no centralized information system that accumulates data related to performance standards or outcome measures. This article analyzes the scope and scale of services provided by FBOs and the diverse approaches to studying the outcomes from these services