62 research outputs found
On the possibility of superconductivity in PrBa2Cu3O7
Recent reports about observations of superconductivity in PrBa2Cu3O7 raise a
number of questions: (i) of various theories striving to explain the Tc
suppression in PrxY{1-x}Ba2Cu3O7, are there any compatible with possible
superconductivity in stoichiometric PrBa2Cu3O7? (ii) if this superconductivity
is not an experimental artifact, are the superconducting carriers (holes) of
the same character as in the other high-Tc cuprates, or do they represent
another electronic subsystem? (iii) is the underlying mechanism the same as in
other high-Tc superconductors? I present an answer to the first two questions,
while leaving the last one open.Comment: 4 pages 4 eps fig
Friedel oscillations in a two-band Hubbard model for CuO chains
Friedel oscillations induced by open boundary conditions in a two-band
Hubbard model for CuO chains are numerically studied. We find that for
physically realistic parameters and close to quarter filling, these
oscillations have a 2k_F modulation according with experimental results on
YBa_2Cu_3O_{7-delta}. In addition, we predict that, for the same parameters, as
hole doping is reduced from quarter filling to half filling, Friedel
oscillations would acquire a 4k_F modulation, typical of a strongly correlated
electrons regime. The 4k_F modulation dominates also in the electron doped
region. The range of parameters varied is very broad, and hence the results
reported could apply to other cuprates and other strongly correlated compounds
with quasi-one dimensional structures. On a more theoretical side, we stress
the fact that the copper and oxygen subsystems should be described by two
different Luttinger liquid exponents.Comment: 7 pages, 7 eps figure
The Superconductivity, Intragrain Penetration Depth and Meissner Effect of RuSr2(Gd,Ce)2Cu2O10+delta
The hole concentration (p)(delta), the transition temperature Tc, the
intragrain penetration depth lambda, and the Meissner effect were measured for
annealed RuSr2(Gd,Ce)2Cu2O10+delta samples. The intragrain superconducting
transition temperature Tc} varied from 17 to 40 K while the p changed by only
0.03 holes/CuO2. The intragrain superfluid-density 1/lambda^2 and the
diamagnetic drop of the field-cooled magnetization across Tc (the Meissner
effect), however, increased more than 10 times. All of these findings are in
disagreement with both the Tc vs. p and the Tc vs. 1/lambda^2 correlations
proposed for homogeneous cuprates, but are in line with a possible
phase-separation and the granularity associated with it.Comment: 7 pages, 6 figures, accepted for publication in Phys. Rev. B (May 2,
2002
Spatial distribution of photoelectrons participating in formation of x-ray absorption spectra
Interpretation of x-ray absorption near-edge structure (XANES) experiments is
often done via analyzing the role of particular atoms in the formation of
specific peaks in the calculated spectrum. Typically, this is achieved by
calculating the spectrum for a series of trial structures where various atoms
are moved and/or removed. A more quantitative approach is presented here, based
on comparing the probabilities that a XANES photoelectron of a given energy can
be found near particular atoms. Such a photoelectron probability density can be
consistently defined as a sum over squares of wave functions which describe
participating photoelectron diffraction processes, weighted by their normalized
cross sections. A fine structure in the energy dependence of these
probabilities can be extracted and compared to XANES spectrum. As an
illustration of this novel technique, we analyze the photoelectron probability
density at the Ti K pre-edge of TiS2 and at the Ti K-edge of rutile TiO2.Comment: Journal abstract available on-line at
http://link.aps.org/abstract/PRB/v65/e20511
RTEL1 contributes to DNA replication and repair and telomere maintenance
Telomere maintenance and DNA repair are important processes that protect the genome against instability. mRtel1, an essential helicase, is a dominant factor setting telomere length in mice. In addition, mRtel1 is involved in DNA double-strand break repair. The role of mRtel1 in telomere maintenance and genome stability is poorly understood. Therefore we used mRtel1-deficient mouse embryonic stem cells to examine the function of mRtel1 in replication, DNA repair, recombination, and telomere maintenance. mRtel1-deficient mouse embryonic stem cells showed sensitivity to a range of DNA-damaging agents, highlighting its role in replication and genome maintenance. Deletion of mRtel1 increased the frequency of sister chromatid exchange events and suppressed gene replacement, demonstrating the involvement of the protein in homologous recombination. mRtel1 localized transiently at telomeres and is needed for efficient telomere replication. Of interest, in the absence of mRtel1, telomeres in embr
Flux Phase as a Dynamic Jahn-Teller Phase: Berryonic Matter in the Cuprates?
There is considerable evidence for some form of charge ordering on the
hole-doped stripes in the cuprates, mainly associated with the low-temperature
tetragonal phase, but with some evidence for either charge density waves or a
flux phase, which is a form of dynamic charge-density wave. These three states
form a pseudospin triplet, demonstrating a close connection with the E X e
dynamic Jahn-Teller effect, suggesting that the cuprates constitute a form of
Berryonic matter. This in turn suggests a new model for the dynamic Jahn-Teller
effect as a form of flux phase. A simple model of the Cu-O bond stretching
phonons allows an estimate of electron-phonon coupling for these modes,
explaining why the half breathing mode softens so much more than the full
oxygen breathing mode. The anomalous properties of provide a coupling
(correlated hopping) which acts to stabilize density wave phases.Comment: Major Revisions: includes comparisons with specific cuprate phonon
modes, 16 eps figures, revte
Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia
Telomerase enables replicative immortality in most cancers including acute myeloid leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in myelofibrosis and myelodysplastic syndromes. Here, we develop an AML patient-derived xenograft resource and perform integrated genomics, transcriptomics and lipidomics analyses combined with functional genetics to identify key mediators of imetelstat efficacy. In a randomized phase II-like preclinical trial in patient-derived xenografts, imetelstat effectively diminishes AML burden and preferentially targets subgroups containing mutant NRAS and oxidative stress-associated gene expression signatures. Unbiased, genome-wide CRISPR/Cas9 editing identifies ferroptosis regulators as key mediators of imetelstat efficacy. Imetelstat promotes the formation of polyunsaturated fatty acid-containing phospholipids, causing excessive levels of lipid peroxidation and oxidative stress. Pharmacological inhibition of ferroptosis diminishes imetelstat efficacy. We leverage these mechanistic insights to develop an optimized therapeutic strategy using oxidative stress-inducing chemotherapy to sensitize patient samples to imetelstat causing substantial disease control in AML
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
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