Vibro-acoustic properties of sandwich structures

The vibro-acoustic properties of three-layered sandwich elements depend on the bending stiffness of the structure. It is found that the apparent bending stiffness of a sandwich beam depends on frequency, its length and boundary conditions. A beam with free ends appears stiffer than the same beam clamped at both ends. The apparent bending stiffness of a sandwich beam with clamped ends decreases as the length of the beam is reduced. The opposite is the case for a beam with free ends. A method for estimating the material parameters of a sandwich beam is described. The frequency and space averages of the point mobility of a finite sandwich beam is found to be equal to the point mobility of an infinite sandwich beam of the same type. Coupling loss factors between sandwich beam elements for some simple types of junctions are given

An integrated acoustic–mechanical development method for off-road motorcycle silencers: from design to sound quality test

Vehicle noise is one of the main sources of complaints because it is widespread and active in almost all environments, from urban areas to rural context. The present work aims to describe a practical procedure to design silencers for off-road motorcycles so that, once produced, they are lightweight, do not affect the engine performances and cut noise emissions to a sustainable limit. The required noise reduction, usually around 35–40 dB, can be achieved only by carefully designing the exhaust system. The first part of the paper provides the theoretical background of noise propagation in ducts, describes the main attenuation devices as tools the designer can use in the development process and outlines the workflow. In the second part, a case study of silencer optimization is presented: the noise emitted by a real off-road motorcycle is characterized and, once the sound pressure level and the mass flow generated by the engine are known, a silencer fulfilling noise attenuation, size and pressure drop requirements is designed, 3D-modeled and rendered. The outcome of the acoustic design process can be used to perform virtual sound quality tests, which can be of interest for manufacturers to catch the attention of passionate users

Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia after Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Abstract BACKGROUND: Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. METHODS: We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. RESULTS: The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45-3.13; P <.001) and auto-HSCT (2.43; 1.22-4.84; P = .01). CONCLUSIONS: Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB. CLINICAL TRIALS REGISTRATION: NCT02088840