Study of CYP3A5 genetic polymorphism in Vietnamese Kinh ethnic group

Cytochrome P450 3A5 (CYP) belongs to the CYP3A cluster, which encode for several enzymes involved in metabolism of various drugs, endogenous substrates as well as exogenous compounds. Among the four genes of CY3A cluster, CYP3A5 plays an important role in pharmacogenetics since this enzyme metabolizes over 30% of the clinically prescribed drugs. The inter-individual variability in clearance of CYP3A substrates mainly depends on the genetic factors. In the present study, after collecting peripheral bloods samples from 100 unrelated healthy Kinh ethnic group in Vietnam, Sanger sequencing was used in order to determine the CYP3A5 variants responsible for enzyme activity alteration (*3, *6, *8 and *9). It was shown that CYP3A5*3 is the most prevalent variant with 67.5%, in which a haft of individuals carrying *3 were homozygous for this allele. In contrast, the variants *6, *8 and *9 were not found the study subjects. The data observed in current study would support dosing of drugs that metabolized by CYP3A5 and thereby increase treatment outcome. 

What Shapes Undergraduate Students’ Satisfaction in Unstable Learning Contexts?

This paper investigates what determinants, and to what extent, they influence students’ satisfaction in unstable learning contexts. Using a national-scaled sample of Vietnamese HEIs with a sound theoretical background, we find that regardless of instabilities from external shocks, the key factors that shape students’ satisfaction are fixed by traditional norms (self-efficacy, infrastructure, lecturer) rather than occasional factors occurring from each event. We find in particular that self-efficacy is the most influential factor for students’ satisfaction and friendship is the most prominent element that enhances students’ self- efficacy. Overall, this paper enriched the literature on student satisfaction, especially during unstable contexts. Thus, it has important implications for educators and HEIs stakeholders in management planning in the time to come

An Analytical Framework Considering the Effects of Online Teaching Quality on Student Satisfaction

COVID-19 spreads across the world in late 2019 has affected to several aspects of social life. One of the most important sectors, which face difficulties was education, thus most universities have transferred from traditional education to online education through the internet to make their academic year going. This study aims to review the effects of online teaching quality on student satisfaction, a positive attitude resulting from an evaluation of students’ online teaching experience in higher education. Through applying the SERVQUAL model to measure the effects of online teaching quality on students’ satisfaction, it can be expected to get better the online teaching quality of higher education institutions in Vietnam. Keywords: Online teaching, student satisfaction, higher education, COVID-19, educational institution. DOI: 10.7176/EJBM/13-6-08 Publication date:March 31st 202

Complete mitochondrial genome of Dong Tao chicken breed (Gallus gallus domesticus) of Vietnam

The complete mitochondrial genome of Dong Tao chicken breed (Gallus gallus domesticus, Dong Tao) was obtained by PCR and sequencing. The complete mitogenome was 16,783 bp in length, with the nucleotide composition for A, T, C, G was 30.29%, 23.75%, 32.48%, and 13.48%, respectively. The mitogenome of Dong Tao chicken contained a non-coding control region (D-loop), 2 rRNA genes, 13 protein-coding genes, and 22 tRNA genes. Phylogenetic analysis revealed that breed Dong Tao chicken breed was sister-close to G. gallus breed Guangxi, and paraphyletic to G. spadiceus, S. jabouillei, and a range of Chinese indigenous, ie. breeds Rugao and Taoyuan

Short Tandem Repeats Used in Preimplantation Genetic Testing of Î’-Thalassemia: Genetic Polymorphisms For 15 Linked Loci in the Vietnamese Population

BACKGROUND: β-thalassemia is one of the most common monogenic diseases worldwide. Preimplantation genetic testing (PGT) of β-thalassemia is performed to avoid affected pregnancies has become increasingly popular worldwide. In which, the indirect analysis using short tandem repeat (STRs) linking with HBB gene to detect different β-globin (HBB) gene mutation is a simple, accurate, economical and also provides additional control of contamination and allele-drop-out ADO. AIM: This study established microsatellite markers for PGT of Vietnamese β-thalassemia patient. METHODS: Fifteen (15) STRs gathered from 5 populations were identified by in silico tools within 1 Mb flanking the HBB gene. The multiplex PCR reaction was optimized and performed on 106 DNA samples from at-risk families. RESULTS: After estimating, PIC values were ≥ 0.7 for all markers, with expected heterozygosity and observed heterozygosity values ranged from 0.81 to 0.92 and 0.53 to 0.86, respectively. One hundred percent of individuals had at least seven heterozygous markers and were found to be heterozygous for at least two markers on either side of the HBB gene. The STRs panel was successfully performed on one at-risk family. CONCLUSION: In general, a pentadecaplex marker (all < 1 Mb from the HBB gene) assay was constituted for β-thalassemia PGT on Vietnamese population

Depression, anxiety and stress among healthcare workers in the context of the COVID-19 pandemic: a cross-sectional study in a tertiary hospital in Northern Vietnam

IntroductionThe outbreak of coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) had significant effects on the mental well-being in general, particularly for healthcare professionals. This study examined the prevalence of depression, anxiety, and stress, and identified the associated risk factors amongst healthcare workers during the COVID-19 outbreak in a tertiary hospital located in Vietnam.MethodsWe conducted a cross-sectional study at a tertiary-level hospital, where the Depression Anxiety and Stress Scale 21 (DASS-21) web-based questionnaire was employed. We analyzed the determinant factors by employing multivariate logistic models.ResultsThe prevalence of depression, anxiety, and stress symptoms were 19.2%, 24.7%, and 13.9%, respectively. Factors such as engaging in shift work during the pandemic, taking care of patients with COVID-19, and staff’s health status were associated with mental health issues among health professionals. In addition, having alternate rest periods was likely to reduce the risk of stress.ConclusionThe prevalence of mental health problems in healthcare workers during the COVID-19 pandemic was relatively high. Having resting periods could potentially mitigate the development of stress among health professionals. Our findings could be taken into account for improving mental health of the health professional population

Spatiotemporal evolution of SARS-CoV-2 Alpha and Delta variants during large nationwide outbreak of COVID-19, Vietnam, 2021

We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha and Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The Delta variant was confined to the AY.57 lineage and caused >1.7 million infections and >32,000 deaths. Viral transmission was strongly affected by nonpharmaceutical interventions

Effects of water scarcity awareness and climate change belief on recycled water usage willingness: Evidence from New Mexico, United States

The global water crisis is being exacerbated by climate change, even in the United States. Recycled water is a feasible alternative to alleviate the water shortage, but it is constrained by humans’ perceptions. The current study examines how residents’ water scarcity awareness and climate change belief influence their willingness to use recycled water directly and indirectly. Bayesian Mindsponge Framework (BMF) analytics was employed on a dataset of 1831 residents in Albuquerque, New Mexico, an arid inland region in the US. We discovered that residents’ willingness to use direct recycled potable water is positively affected by their awareness of water scarcity, but the effect is conditional on their belief in the impacts of climate change on the water cycle. Meanwhile, the willingness to use indirect recycled potable water is influenced by water scarcity awareness, and the belief in climate change further enhances this effect. These findings implicate that fighting climate change denialism and informing the public of the water scarcity situation in the region can contribute to the effectiveness and sustainability of long-term water conservation and climate change alleviation efforts

COVID-19 Social Science and Public Engagement Action Research in Vietnam, Indonesia and Nepal (SPEAR): Protocol for a mixed methods study exploring the experiences and impacts of COVID-19 for healthcare workers and vulnerable communities

Background: When the novel coronavirus – SARS-CoV-2 – started to spread globally, there was a call for social and behavioral scientists to conduct research to explore the wider socio-cultural contexts of coronavirus disease 2019 (COVID-19), to understand vulnerabilities, as well as to increase engagement within communities to facilitate adoption of public health measures. In this manuscript, we describe the protocol for a study conducted in Indonesia, Nepal, and Vietnam. In the study, we explore how the COVID-19 pandemic is affecting individuals and their communities. We focus on the wider health and economic impacts of COVID-19, in particular emerging and increased burden on mental health, as well as new or deepened vulnerabilities in the communities. The introduction of vaccines has added another layer of complexity and highlights differences in acceptance and inequalities around access.  Methods: We use mixed methods, combining survey methods and social media surveillance to gain a picture of the general situation within each country, with in-depth qualitative methods to gain a deeper understanding of issues, coupled with a synergistic engagement component. We also include an exploration of the role of social media in revealing or driving perceptions of the pandemic more broadly. Participants include health workers and members of communities from 13 sites across the three countries. Data collection is spread across two phases. Phase 1 is concerned with exploring lived experiences, impacts on working lives and livelihoods, mental health and coping strategies. Phase 2 is concerned with acceptance of COVID-19 vaccines, factors that increase and reduce acceptance, and factors that influence access. Conclusions: We will disseminate findings in multiple ways including short reports and policy briefs, articles in peer-reviewed journals, and digital diaries will be edited into short films and uploaded onto social media sites.</ns3:p

Factors Influencing Vietnamese Students Satisfaction toward Universities in Taiwan

[[abstract]]本研究的目的是探討越南學生對就讀台灣地區大學的滿意度，以及了解對其滿意度的影響因素。這項研究發現，越南學生的背景因素和其對對台灣的大學學校的滿意度的影響因素之間的有統計上的差異。此外，本研究也探討學生的準備以及六個有影響滿意因素和總體滿意度之間的關係。最後，本研究分析影響越南學生對台灣地區大學的滿意度的預測因素。 本研究採用網路問卷，調查311位在台灣的大學就讀的越南學生，回答以下四個研究問題。本研究採用Chien(2011)所設計的調查問卷, 內容包括學生的準備度和六個影響滿意度的因素：教育、社會和文化支持、基礎設施和行政支持、經濟上的考慮，安全以及形象和威信，影響到越南學生對台灣的教育機構的整體滿意度。 本研究主要的結論如下： 1. 越南學生對台灣教育機構高度滿意。 2. 在安全方面滿意度，就讀在私立大學的比在國立大學的越南學生表現較高。 3. 在台灣學習越久的越南學生會對台灣教育機構形象和威信較高。 4. 來台前有作學習準備的學生會對教育、社會與文化、機構形象和威信、有提昇滿意度。 5. 學生的準備和所有六個影響因素表現出與整體學生滿意度顯著關係，但只有四個自變項是整體學生滿意度的重要預測構面。這四個變量是基礎設施及行政支持，機構形象和威信，教育和安全，解釋力為52%。[[abstract]]The purpose of this study was to investigate Vietnamese student’s satisfaction level toward Taiwan Universities, and explore the influential factors influencing their satisfaction level. This study determined the difference between the demographic factors and satisfaction influential factors of Vietnamese students toward Taiwan Universities. In addition, this study explored the relationships between student’s preparation and six influential satisfaction factors and the overall satisfaction. Finally, this study analyzed the influence factors influencing the Vietnamese students’ satisfaction toward Taiwan Universities. This study used an online questionnaire to survey 311 Vietnamese students studying in Taiwan. The survey instrument used in this study was modified from Chien (2011) which comprised of students’ preparation and six influential satisfaction factors: education, social and cultural support, infrastructure and administrative support, economic considerations, safety, and image and prestige of institutions and these factors were assumed influencing overall satisfaction of Vietnamese student toward Taiwan education institutions. Major conclusions of the study are as follows: 1. Generally, Vietnamese students perceive a high degree of satisfaction toward Taiwan education institutions. 2. Vietnamese students studying private Universities given a higher degree of satisfaction toward the safety aspect than those who studying in public universities in Taiwan. 3. The longer time that Vietnamese students had studied in Taiwan, the more they are satisfied with the education and image and prestige of the institution. 4. The students who felt they were better prepared before coming to Taiwan showed the higher satisfaction with Education, Social and Culture Surport, and Image and Prestige of Institution of Taiwan’s Universities. 5. The student’s preparation and all six influencing factors exhibited significant relationships with overall student satisfaction but only four independent variables were significant predictors of the overall student satisfaction, the four variables are infrastructure and administrative support, image and prestige of institution, education and safety which explains 52% of the total variance.[[note]]碩