A Socio-Ecological Approach to GIS Least-Cost Modelling for Regional Mining Infrastructure Planning: A Case Study from South-East Sulawesi, Indonesia

Regional planning approaches to mining infrastructure aim to reduce the conflict associated with mining operations and existing land uses, such as urban areas and biodiversity conservation, as well as the cumulative impacts that occur offsite. In this paper, we describe a method for conducting Geographical Information System (GIS) least-cost path and least-cost corridor analysis for linear mining infrastructure, such as roads. Least-cost path analysis identifies the optimal pathways between two locations as a function of the cost of traveling through different land use/cover types. In a case study from South-East Sulawesi, Indonesia, we identify potential linear networks for road infrastructure connecting mines, smelters, and ports. The method used interview data from government officials to characterise their orientation (perceived importance and positive/negative attitude) toward the social and environmental factors associated with mining infrastructure. A cost-surface was constructed by integrating spatial layers representing the social and environmental factors to identify areas that should be avoided and areas that were compatible with linear infrastructure using the least-cost path analysis. We compared infrastructure scenario outputs from local and national government officials by the degree of spatial overlap and found broad spatial agreement for infrastructure corridors. We conclude by discussing this approach in relation to the wider social-ecological and mine planning literature and how quantitative approaches can reduce the conflict associated with infrastructure planning

Flexible Frequency Discrimination Subsystems for Reconfigurable Radio Front Ends

<p/> <p>The required flexibility of the software-defined radio front end may currently be met with better overall performance by employing tunable narrowband circuits rather than pursuing a truly wideband approach. A key component of narrowband transceivers is appropriate filtering to reduce spurious spectral content in the transmitter and limit out-of-band interference in the receiver. In this paper, recent advances in flexible, frequency-selective, circuit components applicable to reconfigurable SDR front ends are reviewed. The paper contains discussion regarding the filtering requirements in the SDR context and the use of intelligent, adaptive control to provide environment-aware frequency discrimination. Wide tuning-range frequency-selective circuit elements are surveyed including bandpass and bandstop filters and narrowband tunable antennas. The suitability of these elements to the mobile wireless SDR environment is discussed.</p

The Interface between Cell Signaling Pathways and Pregnane X Receptor

Highly expressed in the enterohepatic system, pregnane X receptor (PXR, NR1I2) is a well-characterized nuclear receptor (NR) that regulates the expression of genes in the liver and intestines that encode key drug metabolizing enzymes and drug transporter proteins in mammals. The net effect of PXR activation is to increase metabolism and clear drugs and xenobiotics from the body, producing a protective effect and mediating clinically significant drug interaction in patients on combination therapy. The complete understanding of PXR biology is thus important for the development of safe and effective therapeutic strategies. Furthermore, PXR activation is now known to specifically transrepress the inflammatory- and nutrient-signaling pathways of gene expression, thereby providing a mechanism for linking these signaling pathways together with enzymatic drug biotransformation pathways in the liver and intestines. Recent research efforts highlight numerous post-translational modifications (PTMs) which significantly influence the biological function of PXR. However, this thrust of research is still in its infancy. In the context of gene-environment interactions, we present a review of the recent literature that implicates PXR PTMs in regulating its clinically relevant biology. We also provide a discussion of how these PTMs likely interface with each other to respond to extracellular cues to appropriately modify PXR activity

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

Despite our rapidly growing knowledge about the human genome, we do not know all of the genes required for some of the most basic functions of life. To start to fill this gap we developed a high-throughput phenotypic screening platform combining potent gene silencing by RNA interference, time-lapse microscopy and computational image processing. We carried out a genome-wide phenotypic profiling of each of the approximately 21,000 human protein-coding genes by two-day live imaging of fluorescently labelled chromosomes. Phenotypes were scored quantitatively by computational image processing, which allowed us to identify hundreds of human genes involved in diverse biological functions including cell division, migration and survival. As part of the Mitocheck consortium, this study provides an in-depth analysis of cell division phenotypes and makes the entire high-content data set available as a resource to the community