Energy Resolution Performance of the CMS Electromagnetic Calorimeter

The energy resolution performance of the CMS lead tungstate crystal electromagnetic calorimeter is presented. Measurements were made with an electron beam using a fully equipped supermodule of the calorimeter barrel. Results are given both for electrons incident on the centre of crystals and for electrons distributed uniformly over the calorimeter surface. The electron energy is reconstructed in matrices of 3 times 3 or 5 times 5 crystals centred on the crystal containing the maximum energy. Corrections for variations in the shower containment are applied in the case of uniform incidence. The resolution measured is consistent with the design goals

Les organismes génétiquement modifiés d'origine végétale

REIMS-BU Santé (514542104) / SudocSudocFranceF

Age-related accumulation of lysosomes and other cytological features in active thyroid follicles of the CBA mouse

This study attempts to elucidate the mechanism through which lysosomal accumulation occurs with age in the epithelial cells of the thyroid gland and especially in the 'active' follicles of the aging mouse thyroid. Thyroid morphology and function in old CBA (at least 24 months of age) male mice were compared with those in young (2 months of age) animals. The effects of different intake of iodine were tested and compared in both cohorts, each of which was divided into three groups :(i) low iodine group, (ii) moderate iodine group, and (iii) high iodine group. As expected, the present work confirmed the well-known accumulation with age of 'cold' follicles coexisting with 'active' follicles in the old mouse thyroid. Attention has been focused on the active follicles whose follicular cells contained in their cytoplasm a large number of pleomorphic dense bodies. The lysosomal nature of these bodies, referred to as secondary lysosomes, was confirmed by histochemistry; however, they displayed variability in acid phosphatase staining. In old animals, regardless of the type of iodine regimen, the ratio between relative follicular volume and relative colloid volume as determined by morphometry remained unchanged. Ultrastructurally, the relative volume occupied by secondary lysosomes in 'active' follicles was always higher than in the young groups. Autoradiographic studies with 125I revealed that a large part of the radioactivity was located in secondary lysosomes of thyroid cells in 'active' follicles of old mice when radioiodine was injected 3 weeks before death. Two different types of vacuoles were present in a non-negligible number of thyrocytes of the 'active' follicles in aged cohorts. The first type was made up of grossly dilated rough endoplasmic cisternae, the second corresponded to intracytoplasmic microfollicular vacuoles. Both aspects have been described in conditions of chronic stimulation. It is concluded (1) that different intake of iodine for 6 weeks does not modulate the thyroid morphology in old mice; (2) that in the thyrocytes of the 'active' follicles in old mice accumulation of secondary lysosomes occurs due to a slowdown of turnover; and (3) that the follicular cells of 'active' follicles feature morphological aspects suggesting a hyperactive state compensating the lack of hormone production in the 'cold' follicles.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Subacute pancerebellar syndrome associated with systemic lupus erythematosus

A pancerebellar syndrome of subacute progression associated with cerebellar atrophy is highly suggestive of a paraneoplastic cerebellar degeneration (PCD). We describe a 27-year-old woman with systemic lupus erythematosus (SLE) that presented with a subacute pancerebellar syndrome. Serum and CSF anti-Yo, anti-Hu and anti-Ri antibodies were not found neither in blood, nor in CSF. Brain MRI showed a cerebellar atrophy. The cerebellar ataxia improved markedly following corticosteroids administration. This case probably demonstrates that an antineuronal antibody-negative subacute cerebellar disease may not only be a manifestation of paraneoplastic disease, but that it can also be associated with SLE.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Effects of antisense hsp27 gene expression in osteosarcoma cells.

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Mechanical Analysis of the FRESCA2 Dipole During Preload, Cool-Down, and Powering

International audienceThe FRESCA2 dipole magnet is being developed within a collaboration between CEA Saclay and CERN. The main goal of the magnet is to provide a 13 T nominal bore field into a clear aperture of 100 mm diameter, for the second generation cable test facility FRESCA2 at CERN. Two magnet assemblies have been done with different coils. The assemblies have been preloaded at room temperature, cooled-down in liquid helium, and powered with several current cycles. The magnet is mechanically instrumented with strain gauges on the external shell, tie rods, and central post of the coils. Strain data are compared with a 3-D mechanical model, in order to validate different assumptions such as friction coefficients, material properties, and prestress levels. This paper reports the results of the mechanical measurements collected during preload, cool-down, powering, and warm-up of the magnet