Lemierre's syndrome and genetic polymorphisms: a case report

BACKGROUND: Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the host detection of pathogen or the resultant systemic reaction. CASE PRESENTATION: A 17-year old female, with no previous medical history, was admitted to the intensive care unit for septic shock, acute respiratory distress syndrome and Lemierre's syndrome. Her DNA was assayed for single nucleotide polymorphisms previously incriminated in the detection of the pathogen, the inflammatory response and the coagulation cascade. We observed functional variations in her Toll like 5 receptor (TLR 5) gene and two coagulation variations (Tissue Factor (TF) 603 and Plasminogen-Activator-Inhibitor-1 (PAI-1) 4G-4G homozygosity) associated with thrombotic events. CONCLUSION: The innate immune response and the prothrombogenic mutations could explain, at least in part, the symptoms of Lemierre's syndrome. Genomic study of several patients with Lemierre's syndrome may reveal its pathophysiology

FESTIVAL D'AIX-EN-PROVENCE 1956 : "PLATEE" comédie-ballet en 3 actes et 1 prologue / Jean-Philippe RAMEAU - Réalisation Renée VOILLIER ; Paroles de J. AUTREAU - A.J. LE VALLOIS D'ORVILLE ; Janine MICHEAU, Christiane CASTELLI, Nadine SAUTEREAU, Monique LINVAL, Michel SENECHAL, Nicolaï GEDDA, Jacques JANSEN Hug SANTANA, Jean-Christophe BENOIT, Robert TROPIN, les Choeurs d'Elisabeth BRASSEUR et l'Orchestre de la Société des Concerts du Conservatoire dirigé par Hans ROSBAUD

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