Association of Biomarkers with the Risk of Developing Type 2 Diabetes.

<p>The length of bars denotes total number of incident type 2 diabetes cases from all studies for each biomarker. Each bar is divided by the solid vertical lines which correspond to different study for each biomarker. Red colour indicates a positive statistically significance, blue colour an inverse statistically significance and grey colour a null association. Panel a) total number of cases up to 250; b) total number of cases between 250 and 1000; and panel c) total number of cases above 1000.</p

Identified Biomarkers for the Risk of Developing Type 2 Diabetes.

<p>The length of bars denotes total number of incident type 2 diabetes cases across all studies for each biomarker.</p

Flow Diagram of Studies Identified in the Literature Search for the Identification of Biomarkers for T2D.

<p>Flow Diagram of Studies Identified in the Literature Search for the Identification of Biomarkers for T2D.</p

Observational and Prediction Evidence for Biomarker-Type 2 Diabetes Relation.

<p>The size of circles denotes total number of incident type 2 diabetes cases from all observational studies for each biomarker. Data were synthesised from observational evidence, either from the initial review or published meta-analysis studies of the identified biomarkers, and from the prediction research studies for the identified biomarker and the risk of developing type 2 diabetes. Dark green colour indicates high quality prediction research study, light green colour low quality study, and grey colour no evidence in the literature as defined (see the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0163721#sec005" target="_blank">method</a> section).</p