Survival curves of patients with sepsis with or without shock.

<p>Using Kaplan-Meier curves, stratified by Gas6 measurement at admission with a cut-off value of 249% (relative to Gas6 concentration in normal plasma) (<i>P</i> = 0.026, Log-rank test).</p

Flow diagram of patients included in the study.

<p>Flow diagram of patients included in the study.</p

Receiver operator characteristic curve analysis of blood parameters for death in the ICU.

<p>The value of the Area Under the Curve for each blood parameter and the 95% confidence intervals are listed on the bottom right of the figure. APACHE II = Acute Physiology and Chronic Health Evaluation II, IL = Interleukin, SOFA = Sequential Organ Failure Assessment.</p

Performance of different biomarkers to predict mortality based on ROC curve area.

<p>Performance of different biomarkers to predict mortality based on ROC curve area.</p

Correlation between the plasma levels of Gas6 and those of other biomarkers.

<p>Correlation between the plasma levels of Gas6 and those of other biomarkers.</p

Patient characteristics by survival status.

<p>Patient characteristics by survival status.</p

Evolution of Gas6 levels during ICU stay.

<p>The scheme is based on a linear mixed model without interaction between time in ICU and survival. Round represent the observed measures in survivors (a) and non-survivors (b), respectively. Lines represent the model-fitted values.</p

Additional file 1 of Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial

Additional file 1: Supplementary Methods, Results, Tables and Figures