64 research outputs found
Changes in the physical structure and chain dynamics of elastin network in homocysteine-cultured arteries
Get PDFThe thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries. The physical structure of this amorphous protein was investigated by differential scanning calorimetry (DSC). To explore the molecular dynamics of the elastin network in the nanometer range, we used thermally stimulated currents (TSC), a dielectric technique running at low frequency, and measuring the dipolar reorientations in proteins subjected to a static electrical field. Combining DSC and TSC experiments reveals the molecular mobility of the proteins, both in the glassy state and in the liquid state. Significant differences are evidenced in the physical structure and relaxation behavior of elastin network in cultured arteries (physiological and pathological concentrations of homocysteine) and discussed
Influence of homocysteine on the physical structure and molecular mobility of elastin network in cultured arteries
Get PDFThe thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries. The glass transition of this amorphous protein was investigated by Differential Scanning Calorimetry (DSC). To explore the molecular dynamics of the elastin network in the nanometer range, we used Thermally Stimulated Currents (TSC), a dielectric technique running at low frequency and measuring the dipolar reorientations in proteins subjected to a static electrical field. Combining TSC and DSC experiments with determination of the activation parameters of relaxation times reveals the molecular mobility of the proteins. The major differences in the relaxation behavior of elastin between arteries cultured with physiological and pathological concentrations of homocysteine are discussed
liac meeting on vascular research 2013
Get PDF1Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, 07100 Sassari, Italy 2Dipartimento di Ingegneria Civile, Ambientale, Aerospaziale, dei Materiali, Universita degli Studi di Palermo, 90128 Palermo, Italy 3Departement de Biologie Pharmaceutique-Laboratoire de Biochimie Fondamentale, Moleculaire et Clinique, Universite d'Aix-Marseille, INSERM UMR S1076, 13385 Marseille, France 4G.I.R. BIOFORGE (Group for Advanced Materials and Nanobiotechnology), Universidad de Valladolid, CIBER-BBN, 47011 Valladolid, Spai
Intérêt de la calprotectine comme marqueur non invasif dans le diagnostic et le suivi des maladies inflammatoires chroniques intestinales
No full textAIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF
Mer et cosmétiques (bien-être et beauté de l'Antiquité à nos jours)
No full textAIX-MARSEILLE2-BU Pharmacie (130552105) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF
La place de l'aspartame dans la lutte contre l'obésité
No full textAIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF
La peau et le vieillissement cutané
No full textAIX-MARSEILLE2-BU Pharmacie (130552105) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF
L' insuline glargine, premier analogue lent de l'insuline dans le traitement du diabète
No full textAIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF
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