Participant characteristics.

<p>Data displayed as median [IQR] or number (%)</p><p>* = higher values represent greater deprivation</p><p>^† = Fasting insulin data missing for 12 Ala12 carriers and 50 Pro12 homozygotes due to insufficient blood collection or cessation of bleeding</p><p>^‡ = 2-h insulin data missing for 14 Ala12 carriers and 59 Pro12 homozygotes due to insufficient blood collection or cessation of bleeding</p><p>^§ = Matsuda-ISI data missing for 21 Ala12 carriers and 89 Pro12 homozygotes; higher values indicate greater sensitivity</p><p>Participant characteristics.</p

Associations of moderate-to-vigorous physical activity (MVPA) and sedentary time with markers of insulin sensitivity.

<p>Coefficients represent the factor by which the measure of insulin sensitivity is multiplied by (95% Confidence Interval) for a 30 minute difference in sedentary time or MVPA</p><p>Model 1 adjusted for age, sex, ethnicity, smoking status, statin medication status, beta-blocker status and accelerometer wear time</p><p>Model 2 adjusted for above variables plus MVPA (for the sedentary time model) or sedentary time (for the MVPA model)</p><p>Model 3 adjusted for the above plus BMI</p><p>Associations of moderate-to-vigorous physical activity (MVPA) and sedentary time with markers of insulin sensitivity.</p

Additional file 1: Table S1. of Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

Discovery results for all models that passed replication thresholds for MEF analysis. Column header definitions provided at the end. Table S2. Discovery results for all models that passed replication thresholds for Biofilter analysis. Column header definitions provided at the end. (PDF 1649 kb