Additional file 1: of The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling

Figure S1. Granulocyte-colony stimulating factor and DMSO vehicle do not induce proliferation of Ewing sarcoma cell lines in vitro. Figure S2. Serum-deprivation does not alter cell line groups of CXCR4-high and -low surface expressions. (PDF 625 kb

Additional file 2: of The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling

Table S1. Plerixafor treatment changes receptor tyrosine kinase phosphorylation patterns in CXCR4-high and -low Ewing sarcoma cell lines. (PDF 1503 kb

DataSheet_1_Online searches for hepatocellular carcinoma drugs mirror prescription trends across specialties and changes in guideline recommendations.docx

Background & aimsThe treatment options for systemically progressed hepatocellular carcinoma (HCC) have significantly expanded in recent years. In this study, we aimed to evaluate the potential of Google searches as a reflection of prescription rates for HCC drugs in the United States (US).MethodsWe conducted an in-depth analysis of US prescription data obtained from the IQVIA National Prescription Audit (NPA) and corresponding Google Trends data from January 2017 to December 2022. We focused on drugs used in the first line and second or later treatment lines for HCC, collecting data on their prescriptions and search rates. Search volumes were collected as aggregated search queries for both generic drugs and their respective brand names.ResultsDuring the study period from Q1 2017 to Q4 2022, monthly prescriptions for drugs used in HCC treatment showed an 173% increase (from 1253 to 3422). Conversely online searches increased by 3.5% (from 173 to 179 per 10 million searches). Notably, strong correlations were observed between search interest and prescriptions for newer drugs, which indicates increasing usage, while older drugs with declining usage displayed limited correlation. Our findings suggest a growing role of non-physician professions in managing systemically progressed HCC within the US healthcare system, although oncologists remained primarily responsible for drug prescriptions.ConclusionsIn conclusion, online search monitoring can offer the potential to reflect prescription trends specifically related to the treatment of HCC. This approach provides a swift and accessible means of evaluating the evolving landscape of HCC treatment.</p