Baseline demographic, lifestyle and clinical characteristics of study participants included at various study follow-up phases.^*

<p>Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); MDD, major depressive disorder; OCP, oral contraceptive pill.</p>*<p>All values expressed as mean (SD), unless otherwise specified.</p>‡<p>Calcium intake calculated from dietary and supplement sources.</p>§<p>Index of physical fitness, meters covered in 12-minut</p

BMD values adjusted by BMI in women with depression versus control women at each main skeletal site.^*

<p>BMD values adjusted by BMI in women with depression versus control women at each main skeletal site.^*</p

Study flow diagram.

<p>Note: The number of exclusions does not match the number of people as some participants were found to have more than one exclusionary criterion.</p

Bone mineral density measurements in women with MDD and moderate osteopenia or osteoporosis randomized to alendronate <i>vs.</i> placebo.

<p>Over 12 months, the Alendronate group showed a significant increase in BMD at the lumbar spine (P = 0.003), and there was a trend for increased BMD at the femoral neck (P = 0.06). No changes over time were observed in the Placebo group.</p

Calcium metabolism, bone turnover markers, and hormonal measurements in women with depression compared to control women.^*

*<p>All values expressed as mean (SD), unless otherwise specified.</p>‡<p>25-Hydroxyvitamin D, ng/mL levels were only obtained at baseline.</p><p>Sample size indicated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040894#pone-0040894-t001" target="_blank">Table 1</a>.</p

Circadian profiles of plasma ACTH, cortisol, and leptin.

<p>Circadian profiles of plasma ACTH, cortisol, and leptin.</p

Clinical characteristics of depressive subtypes of women with unipolar MDD.

<p>Values are reported as mean ± SD or percent.</p><p>Sample size in parenthesis, unless otherwise indicated.</p><p>Significant comparisons, assessed as p≤.05 nominal value.</p>b<p>Atypical differed from undifferentiated.</p

Synopsis of significant findings in the three subtypes of depression vs. healthy controls.

<p>Synopsis of significant findings in the three subtypes of depression vs. healthy controls.</p

Demographic characteristics of depressive subtypes of women with unipolar MDD.

<p>Values are reported as mean ± SD or percent.</p><p>Sample size in parenthesis, unless otherwise indicated.</p><p>Significant comparisons, assessed as p≤.05 nominal value.</p><p><b>Overall</b>: overall test.</p>a<p>Atypical differs from control.</p>b<p>Undifferentiated differs from control.</p

Metabolic, body composition, and bone mineral density measures.

<p>Values are reported as mean ± SD or percent.</p><p>Sample size in parenthesis, unless otherwise indicated.</p><p>Significant comparisons, assessed as p≤.05 nominal value.</p>a<p>Atypical differs from control.</p>b<p>Melancholic differs from control.</p>c<p>Undifferentiated differs from control.</p