Drop in Haemoglobin Level during the Malaria Season according to HbAS, G6PD Deficiency, and Haptoglobin Genotype

<p>Haemoglobin levels at the start and end of the malaria season are shown by haptoglobin genotype ( <i>Hp^2/2</i> versus <i>Hp^1/1</i> and <i>Hp^1/2</i> combined), HbAS compared to HbAA and G6PD (A type) deficiency, wild-type, heterozygotes, and homozygotes/hemizygotes. Error bars denote standard error of the mean. </p

Sample Construction

<p>At the start of the malaria season, 780 children (aged 2–6 y) were recruited from ten rural Gambian villages, of these, 61 children were lost to follow-up (of whom four died). At the end of the malaria season, 707 children were surveyed. A total of 671 children had complete haemoglobin, malaria blood film, and haptoglobin genotype data. After biochemical assays and further genotyping, 565 children had complete data for multivariate regression analysis.</p